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IJCRR - 6(12), June, 2014

Pages: 33-42

"CYCLOOXYGENASE-2" - A VIBRANT CHEMICAL MEDIATOR IN A PLETHORA OFORAL LESIONS

Author: Aditi Amit Byatnal, Subhalakshmi Sen, Amit Byatnal, Monica Charlotte Solomon

Category: Healthcare

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Abstract:

Cyclooxygenase (COX) is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Constituting a key regulatory enzyme of the ecosanoid biosynthetic pathway, COX catalyzes the conversion of arachidonic acid to protaglandinG2 (PGG2) and PGH2 and subsequently to a variety of eicosanoids. COX-2 is one of the isoforms of COX, which was upheld mainly as an inflammatory, inducible enzyme, having role different than that of COX-1. However, more recent studies are beginning to reveal additional functions of COX-2, especially in oral lesions.Most commonly studied area of interest being oral squamous cell carcinoma, along with salivary gland tumors, reactive inflammatory lesions and so on. The objective of this review is to discuss the role of COX-2 in various oral lesions.

Keywords: Cyclooxygenase, prostanoids

Citation:

Aditi Amit Byatnal, Subhalakshmi Sen, Amit Byatnal, Monica Charlotte Solomon. "CYCLOOXYGENASE-2" - A VIBRANT CHEMICAL MEDIATOR IN A PLETHORA OFORAL LESIONS International Journal of Current Research and Review. 6(12), June, 33-42

References:

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A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for Vol 12 issue 10

A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for Vol 12 issue 09

A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for Vol 12 issue 08

A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for Vol 12 issue 07

A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20

A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR

A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13

A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR

A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR.

A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

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