IJCRR - 6(14), July, 2014
PREVALENCE OF CRYPTOCOCCAL MENINGITIS AMONGST HIV SEROPOSITIVE CASES FROM A TERTIARY CARE HOSPITAL
Author: Rajani Sharma, Nandini Duggal, Shalini Malhotra, Dinesh Shrivastava, Charoo Hans
Background: Cryptococcal meningitis has emerged as an important opportunistic central nervous system (CNS) infection in Human immunodeficiency virus (HIV) positive patients. It is associated with a high mortality rate hence early diagnosis is necessary to improve the prognosis. Objectives: This study was undertaken to determine the prevalence of cryptococcal meningitis in HIV seropositive cases as well as to determine the correlation with CD4 counts. Methods: A total of 50 patients suspected to be suffering from chronic meningitis were subjected to cerebrospinal fluid (CSF) analysis (including India ink preparation, culture by conventional methods and antigen detection). Results: The prevalence of cryptococcal meningitis in this study was 30%. Outcome was fatal in 6/15 cases showing a mortality rate of 40 percent. The patients with CD4 count < 50 cells/ul had highest mortaliy rate i.e. 50%. Conclusion: High prevalence and mortality rate of cryptococcal meningitis in HIV-infected patients require a high index of suspicion and routine mycological surveillance to establish an early diagnosis and appropriate management.
Keywords: Cryptococcus neoformans, HIV, Immunocompromised, Meningitis
Rajani Sharma, Nandini Duggal, Shalini Malhotra, Dinesh Shrivastava, Charoo Hans. PREVALENCE OF CRYPTOCOCCAL MENINGITIS AMONGST HIV SEROPOSITIVE CASES FROM A TERTIARY CARE HOSPITAL International Journal of Current Research and Review. 6(14), July, 32-37
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