IJCRR - 6(14), July, 2014
VALIDATION OF BONE GRAFTS IN PERIODONTAL THERAPY-A REVIEW
Author: Kalpana Gokul, D. Arunachalam, S. Balasundaram, Aruna Balasundaram
Background: Bone grafts are widely used in the treatment of periodontal osseous defects. However, many are unfamiliar with their preparation, exact mechanism of action and processing as well as their use as safe and effective graft materials in periodontal therapy. Also, the clinical benefits of this therapeutic practice require further clarification through a proper review. Aim: The purpose of this review is to access the efficacy of bone replacement grafts in proving demonstrable clinical improvements in periodontal osseous defects. Methods: Data Sources: A literature search was conducted on several medical databases. For study inclusion, all studies that used bone graft in the treatment of periodontal osseous defects were included. Around 80 relevant articles were selected for this review. Results: A large body of evidence clearly indicates that grafts consistently lead to better bone fill than non grafted controls. As more is learned about the biologic process of periodontal regeneration, new graft materials are expected to make the task of periodontal regeneration even more predictable. Conclusion: Bone replacement grafts (BRG) are widely used in the treatment of periodontal osseous defects. Our review of literature strongly suggests better bone fill, gain in clinical attachment level and reduced probing depths with the use of various grafts as compared to non grafted sites. However, the clinical benefits of this therapeutic practice require further clarification through a systematic review of randomized controlled studies. Keywords: bone grafts, periodontal regeneration, prognosis
Keywords: bone grafts, periodontal regeneration, prognosis
Kalpana Gokul, D. Arunachalam, S. Balasundaram, Aruna Balasundaram. VALIDATION OF BONE GRAFTS IN PERIODONTAL THERAPY-A REVIEW International Journal of Current Research and Review. 6(14), July, 07-16
1. Misch CE, Dietsh F: Bone-grafting materials in implant dentistry. Implant Dent 1993;2:158- 167
2. Arun K. Garg . Bone Biology, Harvesting, Grafting for Dental Implants: Rationale and Clinical Applications, Chicago: Quintessence Publishing; 2004.
3. Wood RM, Moore DL. Grafting of the maxillary sinus with intraorally harvested autogenous bone prior to implant placement. Int J Oral Maxillofac Implants 1998; 3:209-14.
4. Urist MR: Bone formation by autoinduction. Science 1965;150:893-899. 5. Rejda BV, Peelen JGJ, deGroot K: Tricalcium phosphate as a bone substitute. J Bioeng 1977; 1:93-97.
6. Jarcho M: Calcium phosphate ceramics as hard tissue prosthetics. Clinical Orthop 1981;157:259-278.
7. Christopher Ogunsalu (2011). Bone Substitutes and Validation, Implant Dentistry - The Most Promising Discipline of Dentistry, Prof. Ilser Turkyilmaz (Ed.).
8. Roberts WE, Turley PK, Brezniak N, Fielder PJ: Implants. Bone physiology and metabolism. Calif Dent Assoc J 1987;15:54- 61.
9. Urist MR. Bone transplants and implants. Fundamental and clinical bone physiology. Philadelphia: JB Lippincott 1980; 331- 368.
10. Marx RE, Saunders TR: Reconstruction and rehabilitation of cancer patients. Reconstructive preprosthetic oral and maxillofacial surgery edited by Fonseca RJ and Davis WH,Philadelphia: WB Saunders: 1986, 347-28.
11. Longacre JJ, Converse JM, Knize DM. Transplantation of bone. In: Converse JM, editors. Reconstructive plastic surgery: principles and procedure in correction, reconstruction and transplantation. 2nd ed. Philadelphia: WB Saunders. 1977; 313-39
12. Mellonig JT, Bowers GM. Regenerating bone in clinical periodontics. A review. J Am Dent Assoc.1990; 121:497-502.
13. Fonseca RJ, Frost D, Zeitler D, Stoelinga PJW. 1986. “Osseous reconstruction of edentulous bone loss.” In Reconstructive preprosthetic oral and maxillofacial surgery, edited by Fonseca RJ, Davis WH. 117-65. Philadelphia: WB Saunders.
14. Mellonig JT. Freeze-dried bone allografts in periodontal reconstructive surgery. Dent Clin North Am 1991;35:505-520.
15. Mellonig J, Bowers G, Bright R, Lawrence J. Clinical evaluation of freeze-dried bone allograft in periodontal osseous defects. J Periodontol 1976; 47:125-129.
16. Mellonig J, Captain DC. Decalcified freezedried bone allografts as an implant material in human periodontal osseus defects. Int J Periodont Res Dent 1984; 6:41-55.
17. Wang E. A, Rosen V, D’Alessandro J. S, Bauduy M, Cordes P, Harada T et al Recombinant human bone morphogenetic protein induces bone formation. Proc. Natl. Acad. Sci. USA 1990; 87:2220-2224
18. Gendler E. Perforated demineralised bone matrix: a new form of osteoinductive biomaterial. J Biomed Master Res 1986; 20:687-697
19. Rabalais, M. L, Yukna, R. A., and Mayer. E. T.: Evaluation of durapatite ceramic as an ailoplastic implant in periodontal osseous defects. I. Initial six-month results. J Periodontol 1981;52:680-689
20. M H Amler. Osteogenic potential of non vital tissues and synthetic implant materials. J Periodontol 1987;58:758-761
21. Le Geros RZ. “Calcium phosphate materials in restorative dentistry: a review.” Adv Dent Res 1988;2:164-80.
22. Froum S J. Human histologic evaluation of HTR polymer and freeze-dried bone allograft. A case report. J Clin Periodontol. 1996;23:615-20.
23. M E Aichelmannreidy et al., "HTR polymer versus hydroxylapatite ceramic grafts in human periodontal defects". J Dent Res 1997;76:3432-3432
24. Yukna RA. Synthetic bone grafts in periodontics. Periodontol 2000. 1993;1:92-99.
25. Forsberg H. Transplantation of Ospurum and bone chips in the surgical treatment of periodontal diseases. Acta Odont Scand 1955:13;235-239
26. Fetner AE, Hartigan MS, Low SB. Periodontal repair using Perio Glass in non-human primates: Clinical and histologic observations. Compendium 1994;15:932–935.