International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Abstract

IJCRR - 6(16), August, 2014

Pages: 07-19

BISPHOSPHONATES IN DENTISTRY AN ASIAN PERSPECTIVE - EVIDENCE BASED REVIEW

Author: Vanaja Krishna Naik, Aruna Balasundaram, Harinath P., Caroline Jacob

Category:

[Download PDF]

Abstract:

Bisphosphonates are drugs with high affinity to bone, which accumulates in the bone matrix for a longer time and affects bone turnover. These are commonly prescribed in the management of malignant metastatic bone disorders and for several benign conditions such as osteoporosis and Paget’s disease. The objective of this review is to provide a comprehensive report on the drug bisphosphonate, clinical applications and its potential adverse effects, with special focus on Asian literature. Frequencies of patients who are on bisphosphonates are increasing in dental clinics these days. However regarding the use of this drug and its clinical implication from Asian countries are sparse, presumably due to under-reporting of cases or possibly wrong diagnoses. Hence we have made an attempt to reinforce the existing knowledge about this topic in Asian context along with latest information for the readers.

Keywords: Bisphosphonates, osteonecrosis of the jaws, Asian perspective, Dental uses, Periodontitis.

 Citation:

Vanaja Krishna Naik, Aruna Balasundaram, Harinath P., Caroline Jacob. BISPHOSPHONATES IN DENTISTRY AN ASIAN PERSPECTIVE - EVIDENCE BASED REVIEW International Journal of Current Research and Review. 6(16), August, 07-19

References:

1. Newman,Takei, Klokkevold, Carranza. Carranza’s Clinical Periodontology 11th edition: Perry R, Klokkevold and Brian L Mealey, Part 5, Chapter 27: influence of systemic condition on the periodontium. Elsevier publications, 2011: 315- 317.

2. Yazdana Arrain, Tahir Masud. Bisphosphonates and osteonecrosis of the jaw – current thoughts. Dent update 2009; 36:415-419.

3. Howard C. Tenenbaum, Avi Shelemay, Bruno Girard, Ron Zohar , Peter C Fritz. Bisphosphonates and Periodontics – Potential application for regulation of bone mass in the periodontium and other therapeutic/diagnostic uses. J Periodontal 2002;73:813-822.

4. Niall M.H McLeod, Peter A.Brennan, Salvatore L. Ruggierro. Bisphosphonate osteonecrosis of the jaw - A historical and contemporary review. The Surgeon 2012; 10: 36-42.

5. R.G.G. Russel, N.B. Watts, F.H. Ebetino, M.J. Rogers Mechansim of action of bisphosphonates – similarities and differences and their potential influence on clinical efficacy. Osteoporos Int 2008;19:733-759.

6. Kate Barker, Simon Rogers. Bisphosphonates associated osteonecrosis of the jaw – a guide for the general dental practitioners. Dental update 2006;33:270-275.

7. Ligia J. Dominguez, Antonio Galioto, Anna Ferlisi, Maria Adele Alessi, Mario Belvedere, Ernesto Putignano, Giuseppe Costanza, Maurizio Bevilacqua, Mario Barbagallo. Intermittent intramuscular clodronate therapy: a valuable option for older osteoporotic women: Age and Ageing 2005; 34: 633–645.

8. Graziani F, Cei S, Guerrero A, LA Ferla F, Vano M, Tonetti M, Gabriele M. Lack of short term adjunctive effect of systemic neridronate in non-surgical periodontal therapy of advanced generalized chronic periodontitis: an open label randomized clinical trial. J. Clin Periodontal 2009;36:419- 427.

9. Hisashi Shinoda, Sadaaki Takeyama, Keiko Suzuki, Shinobu Murakami, and Shoji Yamada Forum Mini review Pharmacological Topics of Bone Metabolism:A Novel Bisphosphonate for the Treatment of Periodontitis. J Pharmacol Sci 106, 555 – 558 (2008).

10. Robert E Marx. Bisphosphonate induced osteonecrosis of the jaws II edition. Chapter 2. Modes of action and pharmacokinetics of the bisphosphonate family. Page no: 9-21. Quintessence publishing, Inc.

11. Gideon A Rodan, Hervert A Fleisch. Bisphosphonates: mechanism of action. J. Clin Invest. 1996;97(12):2692- 2696.

12. Anke J. Roelofs, Keith Thompson, Sharon Gordon. Molecular Mechanisms of Action of Bisphosphonates: Current Status. Clin Cancer Res 2006;12:6222-6230.

13. R. Graham G. Russell. Bisphosphonates: Mode of Action and Pharmacology: Pediatrics 119, Supplement 2, March (2007) s150-s162.

14. Luigi Sinigaglia, Massimo Verenna, Silvia Casari. Pharmacokinetic profile of Bisphosphonates in the treatment of metabolic bone disorders. Clinical cases in mineral and bone metabolism 2007;4(1):30-36.

15. You L, Sheng ZY, Chen JY, Pan L, Chen L. The safety and efficacy of early-stage bi-weekly alendronate to improve bone mineral density and bone turnover in chinese postmenopausal women at risk of osteoporosis J Int Med Res 2011;39(1):302-10.

16. Jeal W, Barradell LB, McTavish D. Alendronate. A review of its pharmacological properties and therapeutic efficacy in postmenopausal osteoporosis: Drugs. 1997 Mar; 53(3):415-34.

17. GL Borromeo, CE Tsao, IB Darby, PR Ebeling. A review of the clinical implication of bisphosphonates in dentistry. Australian Dental Journal 2011;56:2-9.

18. El-Shinnawi UM, El-Tantawy SI. The effect of alendronate sodium on alveolar bone loss in periodontitis (clinical trial): J Int Acad Periodontal. 2003 Jan;5(1):5-10.

19. Michael S. Reddy, Nico C. Geurs, John C. Gunsolley.Periodontal Host Modulation with Antiproteinase, Anti-Inflammatory, and Bone-Sparing Agents.A Systematic Review: Annals of Periodontology December 2003, Vol. 8, No. 1, Pages 12-37.

20. Menezes AM, Rocha FA, Chaves HV, Carvalho CB, Ribeiro RA, Brito GA. Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats. J Periodontol. 2005 Nov;76(11):1901-9.

21. Weinreb M, Quartuccio H, Seedor JG, Aufdemorte TB, Brunsvold M, Chaves E, Kornman KS, Rodan GA. Histomorphometrical analysis of the effects of the bisphosphonate alendronate on bone loss caused by experimental periodontitis in monkeys. . J Periodontal Res 1994 Jan; 29(1):35- 40.

22. G Thirumal Reddy, T M Pramod Kumar, and Veena. Formulation and evaluation of Alendronate Sodium gel for the treatment of bone resorptive lesions in Periodontitis Drug Deliv 2005 ; 12(4):217-22.

23. Jeffcoat MK, Cizza G, Shih WJ, Genco R, Lombardi A. Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis: J Int Acad Periodontol.2007 Jul; 9(3):70-6.

24. Anuj Sharma, A.R. Pradeep: Clinical efficacy of 1% Alendronate Gel in Adjunct to Mechanotherapy in the Treatment of Aggressive Periodontitis: A Randomised Controlled clinical Trial: J Periodontol 2012:83: 19-26.

25. Pradeep AR, Kumari M, Rao NS, Naik SB. 1% Alendronate Gel as Local Drug Delivery in the Treatment of Class II Furcation Defects: A Randomized Controlled Clinical Trial. J Periodontol. 2013 Mar;84(3):307-15.

26. Binderman I, Adut M, Yaffe A. Effectiveness of local delivery of alendronate in reducing alveolar bone loss following periodontal surgery in rats. J Periodontol. 2000 Aug;71(8):1236-40.

27. Yaffe A, Iztkovich M, Earon Y, Alt I, Lilov R, Binderman I. Local delivery of an amino bisphosphonate prevents the resorptive phase of alveolar bone following mucoperiosteal flap surgery in rats J Periodontol. 1997 Sep;68(9):884-9.

28. Sharma A, Pradeep AR. Clinical efficacy of 1% alendronate gel as a local drug delivery system in the treatment of chronic periodontitis: a randomized, controlled clinical trial. J Periodontol. 2012;83(1):11-8.

29. H R Veena, Deepak Prasad. Evaluation of an amino bisphosphonate (Alendronate) in the management of periodontal osseous defects. Journal of Indian Society of Periodontology 2010;14(1):40-45.

30. Pradeep AR, Sharma A, Rao NS, Bajaj P, Naik SB, Kumari M. Local drug delivery of alendronate gel for the treatment of patients with chronic periodontitis with diabetes mellitus: a double-masked controlled clinical trial. J Periodontol. 2012 Oct; 83(10):1322-8.

31. Philip M. Preshaw. Host response modulation in periodontics: Periodontology 2000, 2008;48:92–110. 32. Keith L. Kirkwood, Joni A. Cirelli, Jill E. Rogers and William V. Giannobile. Novel Host Response Therapeutic Approaches To Treat Periodontal Diseases: Periodontology 2000, 2007;43:294–315.

33. Salvi GE, Lang NP. Host response modulation in the management of periodontal diseases. J Clin Peridontol 2005; 32 (Suppl. 6): 108–129.

34. Takaishi Y, Miki T, Nishizawa Y, Morii H. Clinical effect of etidronate on alveolar pyorrhoea associated with chronic marginal periodontitis: report of four cases. J Int Med Res. 2001: Jul-Aug; 29(4):355-65.

35. Zang C, Zhai J, Meng Y, Liang X. Developments in research of local bisphosphonate delivery system of implant denture. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2011: Apr; 28(2):415-8. [Article in Chinese]

36. BasmaMostafa, Ebtehalhamdy, NermineNassif. Combined effect of systemic Bisphosphonates, calcium and vitamin D on alveolar bone in osteoporotic post menopausal females having chronic periodontitis following surgical periodontal therapy. Life science journal 2012;9(3):613-622.

37. Bastian Peter, Olivier Gauthier, Samia La?¨b, Bruno Bujoli, Je´roˆme Guicheux, Pascal Janvier, G. Harry van Lenthe, Ralph Mu¨ ller, Pierre-Yves Zambelli, Jean-Michel Bouler, Dominique P. Pioletti. Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats: J Biomed Mater Res 76A: 133–143, 2006.

38. Ying Gao, Shujuan Zou, Xiaoguang Liu, Chongyun Bao, Jing Hua, The effect of surface immobilized bisphosphonates on the fixation of hydroxyapatite-coated titanium implants in ovariectomized rats: Biomaterials 30 (2009) 1790–1796 [Chinese].

39. Abtahi J, Tengvall P, Aspenberg P. Bisphosphonate coating might improve fixation of dental implants in the maxilla: a pilot study. Int J Oral Maxillofac Surg. 2010 Jul; 39(7):673- 7.

40. Abtahi J, Tengvall P, Aspenberg P. A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants. Bone. 2012 May; 50(5):1148-51.

41. M. Yoshinaria, Y. Odaa, T. Inoueb, K. Matsuzakab, M. Shimono. Bone response to calcium phosphate-coated and bisphosphonate immobilized titanium implants: Biomaterials 23 (2002) 2879–2885.

42. Lane N, Armitage GC, Loomer P, Hsieh S, Majumdar S, Wang HY, Jeffcoat M, Munoz T. Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study. J Periodontol. 2005 Jul; 76(7):1113-22.

43. Rocha M, Nava LE, Vázquez de la Torre C, Sánchez-Márin F, Garay-Sevilla ME, Malacara JM. Clinical and radiological improvement of periodontal disease in patients with type 2 diabetes mellitus treated with alendronate: a randomized, placebo-controlled trial. J Periodontol. 2001 Feb;72(2):204- 9.

44. Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B. American Association of Oral and Maxillofacial Surgeons Position Paper on Bisphosphonate Related Osteonecrosis Of The Jaws. Update: 2009; 67:2-12. Task Force On Bisphosphonate Related Osteonecrosis Of The Jaws.

45. Gareth Brock, Kate Barker, Christopher J Butterworth, Simon Rogers. Practical considerations for treatment of patients taking bisphosphonates medications: An Update. Dent Update 2011;38:313-326.

46. W.Park.N, K.Kim.M, Y.Kim.Y, M.Rhee, H.J.Kim . Osteonecrosis of the jaw induced by oral administration of bisphosphonates in Asian population-5 cases. Osteoporos Int 2010;21:527-533.

47. Hong JW, Nam W, Cha IH, Chung SW, Choi HS, Kim KM, Kim KJ, Rhee Y, Lim SK. Oral bisphosphonate-related osteonecrosis of the jaw: the first report in Asia. Osteoporos Int. 2010 May; 21(5):847-53.

48. Kwon TG, Lee CO, Park JW, Choi SY, Rijal G, Shin HI. Os-teonecrosis associated with dental implants in patients undergoing bisphosphonate treatment. Clin Oral Implants Res. 2012 Dec 26. doi: 10.1111/clr.12088. [Epub ahead of print].

49. Yamazaki T, Yamori M, Ishizaki T, Asai K, Goto K, Takahashi K, Nakayama T, Bessho K. Increased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: a cohort study. Int J Oral Maxillofac Surg. 2012 Nov; 41(11):1397-403. doi: 10.1016/j. ijom.2012.06.020. Epub 2012 Jul 26.

50. Assaf AT, Smeets R, Riecke B, Weise E, Gröbe A, Blessmann M, Steiner T, Wikner J, Friedrich RE, Heiland M, Hoelzle F, Gerhards F. Incidence of bisphosphonaterelated osteonecrosis of the jaw in consideration of primary diseases and concomitant therapies. Anticancer Res. 2013 Sep;33(9):3917-24.

51. Ulmner M, Jarnbring F, Törring O. Osteonecrosis of the Jaw in Sweden Associated With the Oral Use of Bisphosphonate. J Oral Maxillofac Surg. 2013 Aug 28.

52. Braun E, Iacono VJ. Bisphosphonates: case report of nonsurgical periodontal therapy and osteochemonecrosis. Int J Periodontics Restorative Dent. 2006 Aug;26(4):315-9.

53. Bedogni A, Bettini G, Totola A, Saia G, Nocini PF. Oral bisphosphonate-associated osteonecrosis of the jaw after implant surgery: a case report and literature review. J Oral Maxillofac Surg. 2010 Jul; 68(7):1662-6.

54. Hom-Lay Wang, Daniel Weber, Laurie K. McCauley. Effect of Long-Term Oral Bisphosphonates on Implant Wound Healing: Literature Review and a Case Report; Journal of Periodontology, March 2007, Vol. 78, No. 3, Pages 584-594.

55. Bauss F, Pfister T, Papapoulos S. Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat. J Bone Miner Metab 2008;26;406-408.

56. Regina Landesberg, Matthew Cozin, Serge Cremers, Victoria Woo, Stavroula Kousteni, Satrajit sinha, LeeAn Garrett Sinha, Srikala Raghavan. Inhibition of Oral mucosal cell wound healing by bisphosphonates. J Oral Maxillofac Surg 2008; 66:839-847.

57. Kim RH, Lee RS, Williams D, Bae S, Woo J, Lieberman M, Oh JE, Dong Q, Shin KH, Kang MK, Park NH. Bisphosphonates induce senescence in normal human oral keratinocytes. . J Dent Res. 2011 Jun;90(6):810-6.

58. Yazdana Arrail, Tahir Masud. A current update on osteonecrosis of the jaw and bisphosphonates. Dent Update 2011;38:672-678.

59. Cesar A. Migliorati, Jeffrey Casiglia, Joel Epstein, Peter L Jacobsen, Sook-Bin Woo. Managing the care of patients with bisphosphonate-associated osteonecrosis. An American Academy of Oral Medicine Position Paper. JADA 2005; Vol 136: 1658-1668.

60. Robin A Seymour, Graham Walton. Effects of Malignant disease and treatments on oral structures. Dent Update 2009;36:594-603.

61. Ho YF, Lin JT, Wu CY. Oral bisphosphonates and risk of esophageal cancer: a dose-intensity analysis in a nationwide population. Cancer Epidemiol Biomarkers Prev. 2012 Jun;21(6):993-5.

62. Yazdana Arrain, TahirMasud. A recent recommendation on bisphosphonate – associated osteonecrosis of the jaw: Dent Update 2008;35:238-242.

63. Joan otomo-corgel. Osteoporosis and osteopenia: implications for periodontal and implant therapy: Periodontology 2000, Vol. 59, 2012, 111–139.

64. Susan M. What is the optimal duration of bisphosphonate therapy? Cleveland Clinic Journal of Medicine 2011; 78(9): 619-630.

65. Salvatore Ruggiero, Julie Gralow, Robert E Marx, Mark M Schubert, Joseph M Huryn, Bela Toth, Kathryn Damato, Vicente Valero. Practical guidelines for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in Patients with cancer. Journal of Oncology Practice 2006 vol 2, issue 1: 7 – 14.

66. Yoh Sawatari, Robert E Marx. Bisphosphonates and Bisphosphonate induced osteonecrosis. Oral Maxillofacial Surg Clin N Am 2007;19:487-498.

67. Marjorie K Jeffcoat Safety of oral bisphosphonates: controlled studies on alveolar bone Int J Oral Maxillofac Implant 2006;21:349-353.

68. Bertram G. Katzung, Susan B Masters, Antony J Trevor. Basic and Clinical pharmacology 11th edition Tata McGrawHill publication; 2010: Chapter 42 agents that affect bone mineral homeostasis: Daniel D Bikle, 753-772.

69. Stopeck AT, Lipton A, Brody JJ. Denosumab compared with Zolendronic acid for the treatment of bone metastases in patients with advanced breast cancer: A randomized double blind study. J Clin Oncol 2010;28:5132-5139.

70. Pongthorn Narongroeknawin, Maria I. Danila, Lewis G. Humphreys Jr, Andrei Barasch, Jeffrey R.Curtis bisphosphonates associated osteonecrosis of the jaw with healing after teriparatide a review of the literature and a case report . Spec care dentist 2010;30(2):77-82.

71. Pasion EG, Sivananthan SK, Kung AW, Chen SH, Chen YJ, Mirasol R, Tay BK, Shah GA, Khan MA, Tam F, Hall BJ, Thiebaud DComparison of raloxifene and bisphosphonates based on adherence and treatment satisfaction in postmenopausal Asian women. J Bone Miner Metab. 2007; 25(2):105-13.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions