IJCRR - Vol 06 Issue 17, September, 2014
SERUM TOTAL ALKALINE PHOSPHATASE ENZYME LEVEL AND SEVERITY OF CHRONIC PERIODONTITIS
Author: Gopu Chandran Lenin Perumal, Mythili R., Senthil Kumar, Subashini Suyambukesan
Purpose: Conventional diagnosis of chronic periodontitis relaying on the clinical probing methods and radiographic evaluation doesn’t predict the progression or severity of the disease state. The recent methods to identify the status of disease relies on the biochemical mediators and / or enzyme level measurements. One such commonly used enzyme assay is alkaline phosphatase. Estimation of this enzyme has shown proven results in diseases involving bone. Chronic periodontitis is one such disease where there is an appreciable amount of bone destruction. The purpose of this study was to estimate and compare the levels of alkaline phosphatase enzyme in serum of healthy individual and in chronic periodontitis patients with varying severity. Materials and Methods: Serum samples were obtained from 67 individuals. 31 are from healthy individuals and 36 from chronic periodontitis patients categorized as mild, moderate and severe based on clinical attachment loss values. The samples were used to determine the total alkaline activity (ALP) level using a fully automated analyzer. Results: Comparison of the total alkaline phosphatase activity between the control and experimental groups namely mild, moderate and severe chronic periodontitis patients showed an increase in total alkaline phosphatase activity from healthy to mild and moderate. There was a decrease in total ALP level in severe periodontitis patients as compared to moderate chronic periodontitis group. Conclusion: The measurement of alkaline phosphatase level in serum cannot be considered as a standalone enzymatic assay for evaluating the severity of chronic periodontitis. This may provide useful information towards the disease severity and progression if evaluated repeatedly over a period of time.
Keywords: Alkaline phosphatase, Chronic periodontitis, Severity of chronic periodontitis, Serum enzymatic assay
Gopu Chandran Lenin Perumal, Mythili R., Senthil Kumar, Subashini Suyambukesan. SERUM TOTAL ALKALINE PHOSPHATASE ENZYME LEVEL AND SEVERITY OF CHRONIC PERIODONTITIS International Journal of Current Research and Review. Vol 06 Issue 17, September, 41-44
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