CHANGING PATTERNS OF AETIOLOGY OF ACUTE SPORADIC VIRAL HEPATITIS IN INDIA - NEWER INSIGHTS FROM NORTH-EAST INDIA

Anup Kumar Das; Sakir Ahmed; Subhash Medhi; Premashish Kar

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IJCRR - 6(19), October, 2014

Pages: 14-20

CHANGING PATTERNS OF AETIOLOGY OF ACUTE SPORADIC VIRAL HEPATITIS IN INDIA - NEWER INSIGHTS FROM NORTH-EAST INDIA

Author: Anup Kumar Das, Sakir Ahmed, Subhash Medhi, Premashish Kar

Category: Healthcare

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Abstract:

Background: Most common aetiology of viral hepatitis globally is Hepatitis A except in developing countries where Hepatitis E predominates. Geographical variation is present between the west and the east. However, in many developing countries including India, a change in aetiology is being increasingly reported in the past two decades.
Materials & Methods: 591 patients with acute viral hepatitis were prospectively screened to ascertain their aetiology (by appropriate viral markers) in a tertiary care centre from North-East India. Results were double-checked in another tertiary institute in Delhi, including Polymerase Chain Reaction for virus detection. Clinical outcomes, mortality and other relevant findings were recorded. Results: Hepatitis A was the dominant aetiology for both acute and fulminant viral hepatitis that is in contrast to other Indian reports that implicate hepatitis E virus, suggesting our region has certain differences. Overall, 16% developed complications with a 9% mortality. Those with hepatitis B had the poorest outcome. Hepatitis C virus was not detected. 2% had mixed infection. Non-A,B,C,E cases were high. History of herbal/unknown folk medicine intake was present in a large number of patients. Conclusion: North-east India, although relatively underdeveloped, is showing a shift of hepatitis A viral sero-epidemiology. Adults are affected as equally by hepatitis E. The reasons may be multi-factorial. Non-viral acute hepatitis is common here. The consumption of unidentified non-allopathic medications may influence outcome, and requires further evaluation.

Keywords: Acute viral hepatitis, Northeast India, Changing aetiology, Herbal medication induced liver damage

Citation:

Anup Kumar Das, Sakir Ahmed, Subhash Medhi, Premashish Kar. CHANGING PATTERNS OF AETIOLOGY OF ACUTE SPORADIC VIRAL HEPATITIS IN INDIA - NEWER INSIGHTS FROM NORTH-EAST INDIA International Journal of Current Research and Review. 6(19), October, 14-20

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