IJCRR - 6(20), October, 2014
Pages: 21-24
TOTAL ANTIOXIDANT ACTIVITY - A BIOMARKER IN ORAL PRECANCER PATIENTS
Author: Chitra Purohit, Suman Jain, Jaspreet Kaur
Category: Healthcare
[Download PDF]
Abstract:
With weakened antioxidant defenses, body cells and tissues become prone to develop dysfunction and/or disease. Then, the maintainance of adequate antioxidant levels, but not overdosage, is essential to prevent or even manage a great number of disease conditions. Total antioxidant activity (TAA) could be a reliable biomarker of diagnosis and prognosis of oral precancerous lesions like oral leukoplakia (OL) and oral submucous fibrosis (OSMF), although several cautions for its use should be carefully done ( choice of appropriate method, use of other antioxidant biomarkers such as cell antioxidants, genetic antioxidant – response elements or antioxidant vitamins and use of valuable oxidative biomarkers ). TAA could be useful to evaluate nutritional interventions with antioxidant – rich foods on disease risk and prevention. The present study was thus undertaken and an attempt was made to correlate the serum levels of lipid peroxidation, assessed by thio barbituric acid reactive substances (TBARS) and total antioxidant activity (TAA) in relation to oral precancer lesions. The results of this study indicate that imbalance in the redox status of oral precancer patients may be due to enhanced lipid peroxidation and compromised antioxidant defenses.
Keywords: Oral leukoplakia, Total antioxidant activity, Oral submucous fibrosis, Oxidative stress, Oral precancer
Citation:
Chitra Purohit, Suman Jain, Jaspreet Kaur. TOTAL ANTIOXIDANT ACTIVITY - A BIOMARKER IN ORAL PRECANCER PATIENTS International Journal of Current Research and Review. 6(20), October, 21-24
References:
1. Ferrari CKB. Oxidative stress pathophysiology: Searching for an effective antioxidant protection. Int Med J. 2001; 8:175-184.
2. Pindborg JJ. Oral submucous fibrosis as a precancerous condition. J Dent Res. 1966; 45: 546-53.
3. Dave RP. Oral submucous fibrosis. A clinical and etiological study. J Indian Dent Assoc. 1987; 59: 46-51.
4. Melrose RJ. Premalignant oral mucosal diseases. J Calif Dent Assoc. 2001; 29: 593-600.
5. Kusano C, Ferrari B. Total Antioxidant capacity : a biomarker in biomedical and nutritional studies. J of Cell and Mol Biol. 2008; 7: 1-15.
6. Buege JA, Aust SD. The Thiobarbituric Acid assay methods. Enzymol. 1978; 52: 306.
7. Benzie I, Strain JJ. Ferric reducing/ antioxidant power (FRAP) assay. Methods in enzymology (oxidation stress). 1999; 299: 15-27.
8. Gupta S, Reddy MV, Harinath BC. Role of oxidative stress and antioxidants in aetiopathogenesis and management of oral submucous fibrosis. Ind J Clin Biochem. 2004; 19: 138-141.
9. Metkari SB, Tupkari JV, Barpande SR. An estimation of serum malondialdehyde, superoxide dismutase and vitamin A in oral submucous fibrosis and its clinicopathologic correlation. J oral Maxillofac Pathol. 2007; 11: 23-7.
10. Subapriya R, Kumaraguruparan R, Nagini S. Oxidant-Antioxidant Status in Oral Precancer and Oral Cancer Patients. Toxicology Mechanisms and Methods. 2003; 13: 77-81.
11. Balasenthil S, Sahoo GC, Nagini S. Circulatory lipid peroxidation and antioxidants in pharyngeal cancer patients. J Biochem Mol Biol Biophys 2000; 4: 359-362.
12. Skrzydlewska E, Stakiewicz A, Sulkowska M, Kasacka I. Antioxidant status and lipid peroxidation in colorectal cancer. J Toxicol Environ Health. 2001; 62:213-222.
13. Buzby GP, Mullen JL, Steih TP, Roasto EF. Host tumour interactions and nutrient supply. Cancer. 1980; 45:2940- 2947.


|