IJCRR - Vol 06 Issue 23, December, 2014
HEAT SHOCK PROTEIN (HSP60) IN PERIODONTAL DISEASE: A REVIEW
Author: Indumathy P., K. V. Arun, Sai Prashanth P.
Heat shock proteins are stress proteins that are produced by cells in response to environmental stress. They have various roles in the physiological as well as pathological processes of the body. These proteins have often been implicated in the pathogenesis of various diseases. This review discusses the role of heat shock proteins (Hsp 60) in the pathogenesis as well as treatment of periodontal disease.
Keywords: Heat shock protein, Periodontal disease, Immune response
Indumathy P., K. V. Arun, Sai Prashanth P.. HEAT SHOCK PROTEIN (HSP60) IN PERIODONTAL DISEASE: A REVIEW International Journal of Current Research and Review. Vol 06 Issue 23, December, 23-26
1. Newman MG, Carranza FA, Takei H, Klokkevold PR. Carranzas clinical Periodontology. 10th ed. Elsevier health sciences; 2006.
2. Goulhen F,Grenier D, Mayrand D Oral microbial heat-shock proteins and their potential contributions to infections. Crit. Rev. Oral Biol. Med. 2003; 14:399–41.
3. Ellis JR, van Eden W, Young D. Stress proteins as molecular chaperones. . Stress Proteins in Medicine 1996:1-26.
4. Kaufmann SH Heat shock proteins and the immune response Immunol Today 1990; 11: 129-136.
5. Lundqvist C, Baranov V, Teglund S, Hammarstrom S, Hammarstrom ML Cytokine profile and ultrastructure of intraepithelial gamma delta T cells in chronically inflamed gingiva suggest a cytotoxic effector function J Immunol 1994; 153: 2302-2312.
6. Ando T,Kato T,Ishihara K,Ogiuchi H, Okuda K Heat shock proteins in the human periodontal disease process Oral Microbiol Immunol 1995 ; 39 :321-327.
7. Ueki K, Tabeta K, Yoshie H, Yamazaki K Self heat shock protein 60 induces tumor necrosis factor –alpha in monocytederived macrophage: possible role in chronic inflammatory periodontal disease Clin Exp Immunol 2002; 127:72-77.
8. Yamazaki K, OhsawaY, Tabeta. K, Ito H, Ueki K, Oda T, Yoshie H, Seymour GJ. Accumulation of Human Heat Shock Protein 60-Reactive T Cells in the Gingival Tissues of Periodontitis Patients. Infect Immun 2002; 70: 2492–2501.
9. Trivedi, V., Gadhvi, P., Chorawala, M., and Shah, G. (2010). Role of heat shock proteins in immune response and immunotherapy for human cancer. Int J Pharm Sci Rev and Res, 2, 57-62.
10. Tissieres A, Mitchell HK, Tracy UM. Protein synthesis in salivary glands of Drosophila melanogaster: Relation to chromosome puffs J Mol Biol 1974; 85: 389-398.
11. Hendrix RW Purification and properties of groE, a host protein involved in bacteriophage assembly J Mol Biol 1979; 129: 404-408.
12. Csermely P, Yahara I. Heat Shock Proteins. In: Keri G, Toth I, editors. Molecular Pathomechanisms and New Trends in Drug ResearchCRC Press, 2003 p. 67-75.
13. Rose NR The role of infection in the pathogenesis of autoimmune disease Semin immunol 1998 ; 10: 5-13.
14. Tabeta K, Yoshie H, Yamazaki K Characterisation of serum antibody to Actinobacillus actinomycetemcomitans GroEL – like protein in periodontitis patients and healthy subjects Oral Microbiol Immunol 2001; 16:290-295.
15. Young RA, Elliott TJ Stress proteins, infection and immune surveillance Cell 1989 ; 59:5-8.
16. Jarjour WN, Jeffries BD, Davis JS, Welch WJ, Mimura T, Winfield JB Autoantibodies to human stress proteins. A survey of various rheumatic and inflammatory diseases Arthritis Rheum 1991; 34:1133-1138.
17. Wu T, Tanguay RM Antibodies against heat shock proteins in environmental stresses and diseases: friend or foe? Cell Stress and chaperones 2006;11:1-12.
18. Seymour GJ, Gemmell E, Reinhardt RA, Eastcott J, Taubman MA Immunopathogenesis of chronic inflammatory periodontal disease: cellular and molecular mechanisms J Periodontal Res 1993;28: 478-486.
19. Pleguezuelos O, Dainty SJ, Kapas S, Taylor JJ A human oral keratinocyte cell line responds to human heat shock protein 60 through activation of ERK1/2 MAP kinases and upregulation of IL-1 β Clin Exp Immunol 2005; 141: 307-314
20. Amano A, Sharma A,Sojar HT, Kuramitsu HK, Genco RJ Effects of temperature stress on expression of fimbriae and superoxide dismutase by porphyromonas gingivalis Infect immun 1994; 62: 4682-4685.
21. Petit MD, Wassenaar A, van der Velden U, van Eden W, Loss BG Depressed responsiveness of peripheral blood mononu-clear cells to heat –shock proteins in periodontitis patients J Dent Res 1999; 78: 1393-1400.
22. Choi JI, Chung SW, Kang HS,Rhim BY, Park YM, Kim US, Kim SJ Epitope mapping of Porphyromonas gingivalis heat shock protein and human heat shock protein in human atherosclerosis J Dent Res 2004; 83:936-940.
23. Honda T, Domon H, Okui T , Kajita K, Amanuma R, Yamazaki K Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions Clin Exp Immunol 2006;144:35-40.
24. Yamazaki K, Ohsawa Y, Itoh H, Ueki K, Tabeta J, Oda T, Nakajima T, Yoshie H, Saito S, Oguma F, Kodama M, Aizawa Y, Seymour GJ T cell clonality to Porphyromonas gingivalis and human heat shock protein 60 s in patients with atherosclerosis and periodontitis Oral microbial Immunol 2004 ;19:160-167.
25. Ford P, Gemmell E, Walker P, West M, Cullinan M, Seymour G Characterisation of heat shock protein specific T cells in atherosclerosis Clin and Diag Lab Immunol 2005; 12:259- 267.
26. Choi JI, Choi KS, Yi NN, Kim US, Choi JS, Kim SJ. Recognition and phagocytosis of multiple periodontopathogenic bacteria by anti-Porphyromonas gingivalis heat-shock protein 60 antisera. Oral Microbiol Immunol. 2005 Feb; 20(1):51-5.
27. Lee JY, Yi NN, Kim US, Choi JS, Kim SJ, Choi JI. Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria. J Periodontal Res 2006; 41(1):10-14.