IJCRR - 6(24), December, 2014
ASSESSMENT OF ARTERIAL STIFFNESS AMONG MIDDLE AGED OFFSPRING OF DIABETIC PARENTS
Author: Niruba R., Subha K. C., Vijayalakshmi I.
Background: Genetic susceptibility appears to play an important role in the occurrence of Type 2 Diabetes with high prevalence among first degree relatives .Subjects with type 2 diabetes have 2-3 fold increased risk of cardiovascular disease compared with normal population. Aim: To compare the arterial stiffness between normotensive normoglycemic middle aged offspring of diabetic parents (Cases) with normotensive normoglycemic middle aged offspring of Non- diabetic parents (Controls). All participants had a sedentary life style.BMI, Blood pressure and glycemic status was matched between cases and controls. Alcoholics, smokers, subjects with peripheral vascular disease and other illness were excluded. Arterial stiffness was assessed from Reflective Index (RI) and Stiffness Index (SI). Reflective index and Stiffness index was measured using IR1 model digital finger tip photo pulse plethysmograph. Results: Controls RI- MEAN – 47.9 ±2.8%,SI –MEAN 6 ±.7 m/s and Cases -RI- MEAN -55.1± 3.6%,SI MEAN 7±.9 m/s. Paired ‘t ‘test was applied and it showed statistical significance with p value < .001.We conclude that vascular endothelial dysfunction and
arterial stiffness is present from an early stage in subjects with family history of diabetes. Life style modifications are suggested to improve the vessel wall compliance and prevent further progression.
Keywords: Stiffness index, Reflective index, Diabetes mellitus
Niruba R., Subha K. C., Vijayalakshmi I.. ASSESSMENT OF ARTERIAL STIFFNESS AMONG MIDDLE AGED OFFSPRING OF DIABETIC PARENTS International Journal of Current Research and Review. 6(24), December, 31-34
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