NISIN: PRODUCTION AND MECHANISM OF ANTIMICROBIAL ACTION

Sukrita Punyauppa-path; Parichat Phumkhachorn; Pongsak Rattanachaikunsopon

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IJCRR - 7(2), January, 2015

Pages: 47-53

NISIN: PRODUCTION AND MECHANISM OF ANTIMICROBIAL ACTION

Author: Sukrita Punyauppa-path, Parichat Phumkhachorn, Pongsak Rattanachaikunsopon

Category: Healthcare

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Abstract:

Nisin is a heat stable lantibiotic consisting of 34 amino acids. Of these amino acids, there are several unusual amino acids including dehydroalanine, dehydrobutyrine, aminobutyric acid, lanthionine and β-methyllanthionine. It has antimicrobial activity against many species of Gram positive bacteria, but not Gram negative bacteria due to their outer membrane barriers. However, when used in combination with other chemical or physical treatments that destabilize the outer membranes, nisin can inhibit Gram negative bacteria. Nisin has been used as a food preservative in many food industries because it is legally approved as safe for use in food and beverage. The knowledge on the production and mechanism of antimicrobial action of nisin is important for the understanding how nisin contains unusual amino acids and how it kills sensitive bacteria. The knowledge may also be a factor for the successful application of nisin. Therefore, this review focuses on presenting these two aspects of nisin.

Keywords: Bacteriocin, Lactococcus lactis, lanbiotic, nisin

Citation:

Sukrita Punyauppa-path, Parichat Phumkhachorn, Pongsak Rattanachaikunsopon. NISIN: PRODUCTION AND MECHANISM OF ANTIMICROBIAL ACTION International Journal of Current Research and Review. 7(2), January, 47-53

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A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

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A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

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