IJCRR - 7(3), February, 2015
INCREASE IN ANTIBIOTIC RESISTANCE: ARE BACTERIA GROWING WITH PAN
Author: V. S. Deotale, Ruchita Attal, P. Narang
Introduction: Pan Drug Resistant (PDR) bacteria are currently the leading cause of concern to the clinicians as they pose serious therapeutic challenges. A bacteria that is non-susceptible to all agents in all antimicrobial categories has been defined as PDR. This retrospective study has been undertaken to determine the prevalence of PDR –GNRs (Gram negative rods) and to assess the risk factors associated with that in hospitalized patients of our rural hospital.
Material & Method: A total of 1748 GNRs isolated and identified by standard phenotypic methods from various clinical specimens received in this laboratory between 1st June 2011 to 31st May 2012 from IPD patients were enrolled in this study. Antibiotic susceptibility of these isolates was done using Kirby-Bauer disk diffusion method as per CLSI guidelines. Predisposing factors for acquisition of PDR isolates were also studied.
Results: A total of 32 (1.8%) of the 1748 GNRs studied were found to be PDR and these were recovered predominantly from surgical units (31.3%). Among these 45.5% were Acinetobacter species, 24.2% Klebsiella species, 15.2% Pseudomonas aeruginosa and 12.1% E.coli. 53.1% isolates were from pus & wound swabs followed by 21.9% from tracheal swabs. Prolonged hospital stay and patients with surgical interventions were found to be important predisposing factors.
Conclusions: PDR-GNRs are originating in our rural hospital and particularly in patients with having prolonged stay in the hospital.
Keywords: PAN drug, PDR-GNR, Acinetobacter
V. S. Deotale, Ruchita Attal, P. Narang. INCREASE IN ANTIBIOTIC RESISTANCE: ARE BACTERIA GROWING WITH PAN
RESISTANCE? International Journal of Current Research and Review. 7(3), February, 43-47
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