IJCRR - 7(4), February, 2015
TO EVALUATE THE EFFICACY OF ANTHRALIN WITH AND WITHOUT COALTAR IN SHORT CONTACT THERAPY OF MILD TO MODERATE PSORIASIS- A RANDOMIZED DOUBLE BLIND CONTROLLED STUDY
Author: Veena R. M., Satheesh B. C., Sumathy T. K.
Background: Anthralin and coal tar, since their introduction in the treatment of psoriasis have remained one of the main modalities of treatment despite fluctuation. The principle of giving both treatments together is of course not new as the Ingram regime includes both tar baths and anthralin. It has been shown that short contact therapy with the combination of anthralin and coal tar is effective in chronic plaque psoriasis.However, clinical evidence suggested that the addition of coal tar to reduce the irritation and pigmentaion due to anthralin resulted in a compromised efficacy of combinations. The antipsoriatic effect of coal tar itself is low but is boosted when combined with anthralin.
Objectives: To evaluate whether combining the coal tar with anthralin in short contact therapy in mild to moderate chronic plaque psoriasis compromises the efficacy of combination compared to anthralin alone.
Methods: Fifty cases having mild to moderate psoriasis were studied in a double blind randomized controlled study. Twenty five patients in group A were treated with anthralin ointment 0.5% and twenty five patients in group B were treated with combination of coal tar 5% and anthralin. Results were analyzed using PASI scores.
Results: P values at the end of 1st visit, 2nd visit in both the groups Group A and Group B were significant. There was also significant decrease in the PASI score in the patients treated with the combination of anthralin plus coal tar than anthralin alone (P<0.001)
Conclusion: This study demonstrates that the addition of 5% Coal tar to Anthralin regimen (0.05%) in the treatment of mild to moderate chronic plaque psoriasis did not impair the antipsoriatic effect of the combination and also increased the efficacy of the combination.
Keywords: Psoriasis, Anthralin, Dithranol, Coal tar, Short contact therapy, Combination therapy
Veena R. M., Satheesh B. C., Sumathy T. K.. TO EVALUATE THE EFFICACY OF ANTHRALIN WITH AND WITHOUT COALTAR IN SHORT CONTACT THERAPY OF MILD TO MODERATE PSORIASIS- A RANDOMIZED DOUBLE BLIND CONTROLLED STUDY International Journal of Current Research and Review. 7(4), February, 68-71
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