IJCRR - Vol 07 Issue 04, February, 2015
RENAL MANIFESTATIONS IN HEMATOLOGICAL MALIGNANCIES: A PROSPECTIVE STUDY
Author: Tafiq Pandit, Dar Maqsood Ahmad, Mustafa Farhat, Shamima, Lone Shabir Ud Din, Dar Owais Hamied
Background: The renal complications of cancer have become one of the important determinants of prognosis in patients with malignancies and combined efforts of the Hemato-Oncologist and the Nephrologist are required for care of these patients in view of the wide spectrum of syndromes that may occur. These renal complications of hematological malignancies are often preventable or reversible with prompt diagnosis and treatment.
Aims: To study the renal manifestations in haematological malignancies.
Material and Methods: The study entitled “Renal manifestations in hematological malignancies” was carried out in 60 patients with established diagnosis of a hematological malignancy admitted in different departments in Government Medical College, Jammu and associated Hospitals. This prospective study was conducted over a period of one year from 1st November 2008 to 31st October 2009. After confirmation of diagnosis all hematological malignancy patients were evaluated for clinical, biochemical, urinary, ultrasonographic and/or computed tomographic evidence of renal involvement, supported by histopathological confirmation (wherever feasible and indicated).This assessment was done at the time of admission, before institution of specific
treatment protocol for each patient, in the study group.
Observations: To summarize the important observations in the study, we found that significant renal enlargement of 1-4cms was observed in 19 cases and majority of these had bilateral enlargement. Commonest metabolic abnormality was hypokalemia (12 cases) followed by hypophoshatemia observed in 11 patients, 9 patients had hyperuricemia, 8 hypercalcemia and 8 patients had hypocalcemia The other metabolic abnormalities observed in the patients of hematological malignancies included hyponatremia in 7, hyperkalemia in 7, hypouricemia in 4 and hyperphoshatemia in 1 patient.
Conclusion: Renal involvement by tumor, although rare can sometimes be the sole manifestation of a hematological malignancy before it is detectable by routine methods. It can present as renal enlargement, obstructive uropathy, glomernlonephritis, tubular abnormalities or as paraneoplastic syndromes, so by keeping knowledge of these possibilities these tumor related catastrophes can be prevented from occurring or halted before these can endanger the life.
Keywords: Hypokalemia, Nephromegaly, Paraneoplastic, Hperphosphatemia, Glomernlonephritis, Hematological
Tafiq Pandit, Dar Maqsood Ahmad, Mustafa Farhat, Shamima, Lone Shabir Ud Din, Dar Owais Hamied. RENAL MANIFESTATIONS IN HEMATOLOGICAL MALIGNANCIES: A PROSPECTIVE STUDY International Journal of Current Research and Review. Vol 07 Issue 04, February, 27-35
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