IJCRR - Vol 07 Issue 06, March, 2015
ADIPOCYTOKINE VISFATIN - A LINK BETWEEN DIABETES MELLITUS AND PERIODONTITIS - A REVIEW
Author: Shamsiya, Rajasekar S., Lakshmisree S., Little Mahendra
Visfatin is a newly discovered member of adipokine family. It is a visceral adipokine, it has been found in skeletal muscle, liver, bone marrow and lymph. It was originally identified as a cytokine-like secreted protein that synergizes the effect of IL-7 and stem cell factor in promoting the growth and differentiation of B-cell lineage precursors. It is expressed in lymphocytes of peripheral blood and plays a role in lymphocytes maturation and inhibition of neutrophil apoptosis. It is an endocrine, autocrine as well as paracrine protein with many functions including enhancement of cell proliferation, biosynthesis of nicotinamide mono- and dinucleotide and induction of hypoglycemia. Visfatin has been shown to exert insulin mimetic
and pro-inflammatory effects, One of the fundamental functions of visfatin is the modulation of immune and inflammatory processes. It has been reported that visfatin activated nuclear factor-kappa B which has a crucial role in regulating immune responses. Up-regulation of visfatin has been also identified in a variety of pathophysiological conditions of the immune system including rheumatoid arthritis, psoriasis, clinical sepsis and acute lung injury.
Recently, there has been mounting body of studies investigating the association of visfatin with periodontal disease. This article gives an insight about visfatin and its correlation with periodontal disease.
Keywords: Visfatin, Periodontal Disease, Diabetes mellitus, Immunity
Shamsiya, Rajasekar S., Lakshmisree S., Little Mahendra. ADIPOCYTOKINE VISFATIN - A LINK BETWEEN DIABETES MELLITUS AND PERIODONTITIS - A REVIEW International Journal of Current Research and Review. Vol 07 Issue 06, March, 38-43
1. Newmann M G, Takei H H, Klokklevold R P et al. Carranza’s clinical periodontology.W B Saunders company 2006;10th edition.
2. Brian Mealey. Periodontal disease and diabetes: a two way street; Journal of American Dental Association: 2006;137(10 supple):26S-31S.
3. Amano. Host–parasite interactions in periodontitis: microbial pathogenicity and innate immunity:Periodontology 2000 October 2010;Volume 54(1): 9–14.
4. Philip M. Preshaw. Host response modulation in periodontics: Periodontology 2000 October 2008;Volume` 48: (1): 92-110.
5. Giulietti A, Van Etten E, Overbergh L, Stoffels K, Bouillon K, Mathieu C. Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1, 25-Dihydroxyvitamin D (3) works as anti-inflammatory: Diabetes Res Clin Pract.2007 Jul;77:47-57.
6. Wellen K E, Hotamisligil G S. Inflammation, stress, and diabetes: J Clin Invest. 2005 May; 115:1111-9.
7. Kopelman P. Obesity as a medical problem.Nature. 2000; 404:635-643.
8. Caroline FD. Overweight and Obesity as Risk Indicators for Periodontitis in Adults. Journal of Periodontology 2005; 76:1721-1728.
9. Atsunori Fukuhara, Morihiro Matsuda, Masako Nishizawa, Katsumori Segawa, Masaki Tanaka, Kae Kishimoto et al. Visfatin: a protein secreted by visceral fat that mimics the effect of insulin. Science.2005 Jan 21;307: 426-30.
10. Moschen A R, Kaser A, Barbara Enrich, Birgit Mosheimer, Milan Theurl, Harald Niederegger and Herbert Tilg. Visfatin, an Adipocytokine with Proinflammatory and Immunomodulating properties: J Immunol 2007; 178:1748- 1758.
11. S Ognjanovic, S Bao, S Y Yamamoto, J Garibay-Tupas, B Samal and G D Bryant Greenwood. Gnomic organisation of the gene coding for human. J mol.endocrinol 2001;26:107- 117.
12. Brian L Mealey and Thomas Oates. AAP-Commissioned Review Diabetes Mellitus and Periodontal Diseases: J Periodontol August 2006 ;77:1289-1300.
13. Socransky SS. Haffajee AD. Cugini MA, Smith C, Kent Jr. Microbial complexes in subgingival plaque: J Clin Periodontol 1998; 25: 134-144.
14. Richard P. Darveau and Sumita Jain. Contribution of Porphyromonas gingivalis lipopolysaccharide to periodontitis: Periodontology 2000 2010; Vol. 54:53-70.