IJCRR - Vol 07 Issue 07, April, 2015
INFLUENCE OF BREAST CANCER ON SERUM TESTOSTERONE AND SEX HORMONE BINDING
GLOBULIN LEVELS AMONG SUDANESE LADIES
Author: Kamal Eldin Ahmed Abdelsalam
Background: Breast cancer is the most frequent cancer and the second leading cause of cancer deaths among women worldwide and an increasing incidence rate has been observed in Sudan.
Objective: this study was aimed to determine the effect of breast cancer on testosterone and sex hormone binding globulin inSudanese female patients.
Materials: This study included 120 untreated breast cancer patients with clinical and histopathological evidence and 100 healthy volunteers as a control. Venous blood was drawn from the cases and controls.
Methods: Testosterone and sex hormone binding globulin were estimated in blood samples by using radio-immune assay. Paired t-test was used to compare the mean serum levels of testosterone and sex hormone binding globulin between patients and controls.
Results: In the present study there were significant high levels of serum testosterone in premenopausal lady patients with breast cancer as compared to control group (p value <0.05). On the other hand, there were significant low levels of sex hormone binding
globulin in ladies with breast cancer when compared to controls (p value<0.05).
Conclusion: A significant high level of testosterone and low level of sex hormone binding globulin were found in this study.
Keywords: Testosterone, Sex hormone binding globulin, Breast cancer
Kamal Eldin Ahmed Abdelsalam. INFLUENCE OF BREAST CANCER ON SERUM TESTOSTERONE AND SEX HORMONE BINDING
GLOBULIN LEVELS AMONG SUDANESE LADIES International Journal of Current Research and Review. Vol 07 Issue 07, April, 18-21
1. Veljkovic M, Veljkovic S. The risk of breast cervical, endometrial and ovarian cancer in oral contraceptive users. Med Pregl 2010,63:657-661.
2. Goncalves V, Sehovic I, Quinn G. Childbearing attitudes and decisions of young breast cancer survivors: a systematic review. Hum Reprod Update 2014,20:279-292.
3. Maggio M, Cattabiani C, Lauretani F, Mantovani M, Butto V, De Vita F, et al. SHBG and endothelial function in older subjects. Int J Cardiol 2013,168:2825-2830.
4. Saad F. The role of testosterone in type 2 diabetes and metabolic syndrome in men. Arq Bras Endocrinol Metabol 2009,53:901-907.
5. Smith LB, Walker WH. The regulation of spermatogenesis by androgens. Semin Cell Dev Biol 2014,30:2-13.
6. Yasui T, Uemura H, Irahara M, Arai M, Kojimahara N, Okabe R, et al. Associations of endogenous sex hormones and sex hormone-binding globulin with lipid profiles in aged Japanese men and women. Clin Chim Acta 2008,398:43- 47.
7. Sun L, Jin Z, Teng W, Chi X, Zhang Y, Ai W, et al. SHBG in GDM maternal serum, placental tissues and umbilical cord serum expression changes and its significance. Diabetes Res Clin Pract 2013,99:168-173.
8. Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparso T, et al. Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet 2010,19:535-544.
9. Wei S, Schmidt MD, Dwyer T, Norman RJ, Venn AJ. Obesity and menstrual irregularity: associations with SHBG, testosterone, and insulin. Obesity (Silver Spring) 2009,17:1070- 1076.
10. Kumsar S, Kumsar NA, Saglam HS, Kose O, Budak S, Adsan O. Testosterone levels and sexual function disorders in depressive female patients: effects of antidepressant treatment. J Sex Med 2014,11:529-535.
11. El Khoudary SR, McClure CK, VoPham T, Karvonen-Gutierrez CA, Sternfeld B, Cauley JA, et al. Longitudinal assessment of the menopausal transition, endogenous sex hormones, and perception of physical functioning: the Study of Women’s Health Across the Nation. J Gerontol A Biol Sci Med Sci 2014,69:1011-1017.
12. Jukic AM, Weinberg CR, Wilcox AJ, McConnaughey DR, Hornsby P, Baird DD. Accuracy of reporting of menstrual cycle length. Am J Epidemiol 2008,167:25-33
. 13. Choudhury BK, Choudhury SD, Saikia UK, Sarma D. Gonadal function in young adult males with metabolic syndrome. Diabetes Metab Syndr 2013,7:129-132.
14. Abdelsalam KE, Hassan IK, Sadig IA. The role of developing breast cancer in alteration of serum lipid profile. J Res Med Sci 2012,17:562-565.
15. Halava H, Korhonen MJ, Huupponen R, Setoguchi S, Pentti J, Kivimaki M, et al. Lifestyle factors as predictors of nonadherence to statin therapy among patients with and without cardiovascular comorbidities. CMAJ 2014,186:E449-456.
16. Bhaskaran K, Douglas I, Forbes H, dos-Santos-Silva I, Leon DA, Smeeth L. Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet 2014,384:755-765.
17. Biro FM, Pinney SM, Huang B, Baker ER, Walt Chandler D, Dorn LD. Hormone changes in peripubertal girls. J Clin Endocrinol Metab 2014,99:3829-3835.