IJCRR - 7(7), April, 2015
INFLUENCE OF BREAST CANCER ON SERUM TESTOSTERONE AND SEX HORMONE BINDING
GLOBULIN LEVELS AMONG SUDANESE LADIES
Author: Kamal Eldin Ahmed Abdelsalam
Background: Breast cancer is the most frequent cancer and the second leading cause of cancer deaths among women worldwide and an increasing incidence rate has been observed in Sudan.
Objective: this study was aimed to determine the effect of breast cancer on testosterone and sex hormone binding globulin inSudanese female patients.
Materials: This study included 120 untreated breast cancer patients with clinical and histopathological evidence and 100 healthy volunteers as a control. Venous blood was drawn from the cases and controls.
Methods: Testosterone and sex hormone binding globulin were estimated in blood samples by using radio-immune assay. Paired t-test was used to compare the mean serum levels of testosterone and sex hormone binding globulin between patients and controls.
Results: In the present study there were significant high levels of serum testosterone in premenopausal lady patients with breast cancer as compared to control group (p value <0.05). On the other hand, there were significant low levels of sex hormone binding
globulin in ladies with breast cancer when compared to controls (p value<0.05).
Conclusion: A significant high level of testosterone and low level of sex hormone binding globulin were found in this study.
Keywords: Testosterone, Sex hormone binding globulin, Breast cancer
Kamal Eldin Ahmed Abdelsalam. INFLUENCE OF BREAST CANCER ON SERUM TESTOSTERONE AND SEX HORMONE BINDING
GLOBULIN LEVELS AMONG SUDANESE LADIES International Journal of Current Research and Review. 7(7), April, 18-21
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