IJCRR - 7(8), April, 2015
THE STUDY OF PERIPHERAL NEUROPATHY AND AUTONOMIC NEUROPATHY PREVALENCE IN TYPE 2 DIABETES MELLITUS
Author: Bezwada Srinivasa Rao, Madu Anu Radha M. D., Matta Sree Vani M. D.
Background: Type 2 diabetes and its complications are major causes of morbidity and mortality with decreased quality of life. Distal symmetrical poly neuropathies affecting sensory more than motor nerves are common long term micro vascular complications. Prevalence of both peripheral and autonomic neuropathy increases with increased duration of type 2 diabetes. Tight glycemic control and lowering of glycosylated hemoglobin levels are associated with improvement of symptoms and slowing the progression of diabetic neuropathy.
Aim: The aim is to study the prevalence of peripheral neuropathy and autonomic neuropathy and their relation with duration of type 2 diabetes.
Materials and Methods: The present study enrolled 100 patients of type 2 diabetes with age > 30 yrs. Gestational and type1 diabetes patients were excluded from the study. Screening of neuropathy was done by monofilament and vibration tests. Nerve conduction studies were done to confirm neuropathy. Standard tests for autonomic dysfunction like orthostatic hypotension, pulse rate response to deep breaths test, hand grip and valsalva manoeuvre were performed.
Results: In this study, the prevalence of neuropathy was 57% in diabetic patients. Out of 57 patients with neuropathy, 25 patients (43.85%) had only peripheral neuropathy, 6 patients (10.53%) had only autonomic neuropathy and 26 patients (45.62%) had both peripheral and autonomic neuropathy. Prevalence of both peripheral and autonomic neuropathy increased with increased duration of type 2 diabetes.
Conclusions: The most common form is the distal symmetrical poly neuropathy than autonomic neuropathy. Both peripheral and autonomic neuropathies do not invariably coexist in diabetes. Peripheral and autonomic neuropathy increased with increased duration of type 2 diabetes.
Keywords: Autonomic neuropathy, Glycosylated hemoglobin, Micro vascular complications, Nerve conduction studies, Symmetrical poly neuropathy, Type 2 diabetes mellitus
Bezwada Srinivasa Rao, Madu Anu Radha M. D., Matta Sree Vani M. D.. THE STUDY OF PERIPHERAL NEUROPATHY AND AUTONOMIC NEUROPATHY PREVALENCE IN TYPE 2 DIABETES MELLITUS International Journal of Current Research and Review. 7(8), April, 28-33
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