IJCRR - 7(11), June, 2015
Pages: 53-57
TO DETERMINE ASSOCIATION OF LIPID PROFILE, SERUM URIC ACID AND BODY MASS INDEX AS A MARKER FOR PREECLAMPSIA
Author: Shashikant G. Somani, Sonali Rathi Somani, Vrunda Choudhary, P. Sudhir Babu, A. Vijayalaxmi
Category: Healthcare
[Download PDF]
Abstract:
Objective: To detect association of serum lipid profile, uric acid and body mass index in preeclampsia and to measure their clinical significance. Methods: A prospective case-control study was conducted at Kamineni Institute of Medical Sciences, Narketpally. One hundered patients with pre-eclampsia were compared with age matched 100 normotensive pregnant woman. Body mass index was calculated. Blood pressure was measured. Their serum levels of triglycerides (TG), Cholesterol, low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL) and serum uric acid were measured. Data was analysed by students t-test and Chi?square test. Results: Blood pressure, body mass index ,TG, VLDL, LDL, cholesterol and serum uric acid level were significantly higher in preeclamptic women (p<0.05); while serum HDL was significantly low in preeclamptic women (p<0.05). Conclusion: Lipid abnormalities, mostly elevated TG, cholesterol, LDL, VLDL, maternal obesity and uric acid are associated with preeclampsia. Early detection of these parameters may help in their better management.
Keywords: Body mass index, High blood pressure, Lipid profile, Pre-eclampsia, Uric acid
Citation:
Shashikant G. Somani, Sonali Rathi Somani, Vrunda Choudhary, P. Sudhir Babu, A. Vijayalaxmi. TO DETERMINE ASSOCIATION OF LIPID PROFILE, SERUM URIC ACID AND BODY MASS INDEX AS A MARKER FOR PREECLAMPSIA International Journal of Current Research and Review. 7(11), June, 53-57
References:
1. Elisabeth B M, Lars J V, Tom LN et al. Pre pregnancy cardiovascular risk factors as predictors of pre-eclampsia: population based cohort study. British Medical Journal 2007;335: 978-981.
2. Anderson CM and Ren J. Leptin, leptine resistance and endothelial dysfunction in preeclampsia. Cell Mol Biol 2002;48:323-329.
3. Airoldi J, Weinstein L. Clinical significance of proteinuria in pregnancy. Obstet Gynecol Surv. 2007;62(2):117-124.
4. Gohil JT, Patel PK, Gupta P. Estimation of lipid profile in subjects of preeclampsia. J Obstet Gynaecol India 2011;61:399-403.
5. Enaruna NO, Idemudia JO, Aikoriogie PI. Serum lipid profile and uric acid levels in preeclampsia in University of Benin Teaching Hospital. Niger Med J 2014;55:423-427.
6. F.Gary Cummingham, Norman FG, Kenneth et al. Hypertensive disorders in pregnancy, Williams Obstetrics, 22 Edition, Me. Graw Hill 2005:761-764.
7. Atherosclerosis, American Association of Clinical Endocrinologists Task Force for Management of Dyslipidemia and Prevention of American Association of Clinical Endocrinologists. Guidelines for Management of Dyslipidemia and Prevention of Atherosclerosis. Endocrine Practise. 2012;18(Suppl.1).
8. Sharami SH, Tangestani A, Faraji R, Zahiri Z, Azam A. Role of dyslipidemia in pre-eclamptic overweight pregnant women. Iran J Reprod Med 2012;10:105-112.
9. Ephraim R, Doe PA, Amoah S, Antoh EO. Lipid profile and high maternal body mass index is associated with preeclampsia: A case-control study of the Cape Coast Metropolis. Ann Med Health Sci Res 2014;4:746-750.
10. NAF Islam, MAR Chowdhury, GM Kibria, S Akhter Faridpur. Study of serum lipid profile in pre-eclampsia and eclampsia. Med. Coll. J. 2010;5(2):56-59 .
11. Pradnya Phalak, Mona Tilak. Study of lipid profile in preeclampsia. Indian Journal of Basic and Applied Medical Research. 2012; 5, (2) : 405-409.
12. Ray JG, Vermeulen MJ, Schull MJ, Redelmeier DA. Cardiovascular health after maternal placental syndromes (CHAMPS): Population-based retrospective cohort study. Lancet 2005;366:1797-1803.
13. Swapan Das, Debasish Char, Sanjay Sarkar, Prakash Das,Tushar Kanti Saha, Sucheta Biswas. Comparison of lipid profiles in normal pregnancy and in pre-Eclampsia: A case control study. IOSR Journal of Dental and Medical Sciences. 2013; 11(4): 53-55.
14. Karl W, Birgit W, Michael M. H et al. Triglyceride rich lipoproteins are associated with hypertension in preeclampsia. The Journal of Clinical Endocrinology and Metabolism 2003;88(3):1162-1166.
15. Kashinakunti S. V. , Sunitha H , Gurupadappa K, Manjula R. Lipid Profile In Preeclampsia – A Case Control Study. Journal of Clinical and Diagnostic Research 2010 ; 4: 2748- 2751.
16. Cekmen MB. Erhagci AB, Balat A, Duman C, Maral H, Ergen K, et al. Plasma lipid and lipoprotein concentrations in pregnancy induced hypertension. Clin. Biochem. 2003; 36(7):575-578.
17. Pirzado ZA, Sangi SA, Malik R. High density lipoprotein cholesterol metabolism and its role in ischemic heart disease. Pak J Med Res 1999; 38: 38–41.
18. Hawkins TL, Roberts JM, Mangos GJ, Davis GK, Roberts LM, Brown MA. Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: A retrospective cohort study. BJOG 2012;119:484-492.
19. Wu Y, Xiong X, Fraser WD, Luo ZC. Association of uric acid with progression to preeclampsia and development of adverse conditions in gestational hypertensive pregnancies. Am J Hypertens 2012;25:711-717.
|