IJCRR - 7(12), June, 2015
Pages: 44-47
A CLINICOPATHOLOGICAL STUDY OF PEDIATRIC LUPUS NEPHRITIS IN TERITARY HOSPITAL OF BANGALORE
Author: Seema H.S.
Category: Healthcare
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Abstract:
Background: To study the clinical behavior of lupus nephritis in children from Southern India, and to report the differences in disease pattern.
Objectives:
1. To study histopathological changes and outcome in paediatric lupus nephritis.
2. To study the clinical and immunological spectrum of lupus nephritis.
Methodology: Laboratory received renal biopsy specimens with a clinical diagnosis of SLE by ARA criteria over a period of 6 years were included in the study and were classified according to the 1982 WHO Classification and reclassified ISN classification.
Results: Of the 16 cases studied, 12 patients were females (75%). ANA was the most frequently positive parameter occurring in 91% of cases. ds- DNA was positive in 9 cases. Anaemia was present in 10 cases (63%). In our study WHO Class IV lupus nephritis was most the common 63% (n=63). Acute renal failure was seen in 18% of paediatric cases and doubling serum creatinine was noted in 20% of paediatric patients. Interpretation and conclusion: The incidence of disease was 3 times more common in females. WHO class IV was the commonest class, seen in 63% of cases. The percentage of patients having doubling serum creatinine was noted in 20% paediatric age group indicating poor renal outcome and prognosis in children.
Keywords: Paediatric, Systemic lupus erythematosus, Clinical profile, Serum creatinine, Lupus nephritis
Citation:
Seema H.S.. A CLINICOPATHOLOGICAL STUDY OF PEDIATRIC LUPUS NEPHRITIS IN TERITARY HOSPITAL OF BANGALORE International Journal of Current Research and Review. 7(12), June, 44-47
References:
1. Dhir. V, Aggarwal A, Lawrence A, Agarwal V, Misra R.LongTerm Outcome of Lupus Nephritis in Asian Indians. Arthritis Care and Research.2012; 64:713-20.
2. Hafeez F, Tarar AM and Saleem R. Lupus Nephritis in Children. Journal of The College of Physicians and Surgeons Pakistan 2008; 18 (1): 17-21.
3. RuggieroB, Vivarelli M, Gianviti A, Benetti E , Peruzzi L, Barbano G, et al.Lupus nephritis in children and adolescents: results of the Italian Collaborative Study.Nephrol Dial Transplant; 2013: 1-8.
4. Baqi N,Moazami S, Singh A, Ahmad h, Balachandra S , Tejani A. Lupus Nephritis in Children: A Longitudinal Study of Prognostic Factors and Therapy. J. Am. Soc. Nephro.1996; 7:924-29
. 5. Agarwal I, Sathish Kumar T, Ranjini K, Kirubakaran C And Danda D. Clinical Features and Outcome of Systemic Lupus Erythematosus in Children. Indian paediatrics: 2009; 711- 15.
6. Gupta KL. Lupus nephritis in children. Indian J Pediatr 1999; 66:215-23.
7. Chandrasekaran AN, Rajendran CP, Ramakrishnan S, Madhavan R and Parthiban M. Childhood systemic lupus erythematosus in South India. Indian J Pediatr 1994; 61:223- 29.
8. Singh, Surjit, et al. Clinical and immunological profile of SLE: some unusual features. Indian pediatrics 34 (1997): 979-986.
9. Ali US, Dalvi RB, Merchant RH, Mehta KP, Chablani AT, Badakere SS, et al. Systemic lupus erythematosus in Indian children. Indian Pediatrics 1989; 26:868-73.
10. Hari, P, Bagga A,Mahajan P, Dinda A. Outcome of lupus nephritis in Indian children. Lupus 18.4 (2009): 348-354.
11. Yang LY, Chen WP, and Lin CY. Lupus nephritis in children-A review of 167 patients. Pediatrics 1994 Sep; 94(3): 335-40.
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