IJCRR - 7(15), August, 2015
Pages: 68-73
PROFILE OF PATIENTS OF VENOUS THROMBOSIS IN MEDICAL WARDSAN OBSERVATIONAL STUDY
Author: Cheena Garg, Arjun Agarwal, Dhruva Chaudhry
Category: Healthcare
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Abstract:
Introduction: Venous thrombosis is not an uncommon entity in medicine wards. Clinically, in majority of patients of venous thrombosis one or the other risk factor can be identified. Radiological investigations like-Duplex sonography, Coronary Transhepatic Pulmonary Angiography(CTPA) and Magnetic Resonance Imaging (MRI) venography have revolutionized the diagnosis of these disorders. There is an urgent need and scope to identify factors contributing to thrombophilia.
Method: A prospective observational study over a period of 7 months including all the patients admitted in one unit of medicine.
Results: Overall prevalence of venous thrombosis was 4.18% (26 out of 622 patients). The mean age of patients was 40.7 ± 16.2 years. Patients were divided into two groups. Group 1 (19 patients) consisting of patients with venous thrombosis (11 patients) and pulmonary thromboembolism (8 patients). Whereas group 2 (7 patients) had patients with cortical venous thrombosis (CVT). CVT and Deep Vein Thrombosis (DVT) were predominantly seen in females while pulmonary embolism was common in males. While in Group 1, Dyspnoea and pedal oedema were the commonest features. In group 2, headache followed by focal neurological deficit was common. All the cases were confirmed by necessary radiological investigations. All patients received enoxaparin. Thrombololysis
was additionally given to 5 patients of group 1.11 (42%) patients had one or more risk factors. Overall mortality was 26%.
Conclusion: Significant number of patients of venous thrombosis had one or the other risk factors. In this highly selective group wherever the tests were done, they demonstrated presence of thrombophilic state. It reinforces the belief that thrombophilias are prevalent in our population.
Keywords: Venous thrombosis, Pulmonary embolism, Cortical vein thrombosis, Thrombophilias
Citation:
Cheena Garg, Arjun Agarwal, Dhruva Chaudhry. PROFILE OF PATIENTS OF VENOUS THROMBOSIS IN MEDICAL WARDSAN OBSERVATIONAL STUDY International Journal of Current Research and Review. 7(15), August, 68-73
References:
1. Clagett GP, Anderson FA, Jr, Heit J, et al. Prevention of venous thromboembolism. Chest 1995;108 (Suppl 1):31234.
2. Bick RL, Haas S. Thromboprophylaxis and thrombosis in medical, surgical, trauma, and obstetric/gynecologic patients. Hematol Oncol Clin North Am 2003;17:21758.
3. Srinivasan K. Ischemic cerebrovasular disease in the young: Two common causes in India. Stroke 1984;15;733-5.
4. Nagaraja D, Sarma GR. Treatment of cerebral sinus/venous thrombosis. Neurol India 2002;50;2:114-6.
5. Deschiens M. Coagulation studies, factor V leiden, and anticadiolipin antibodies in 40 cases of cerebral venous thrombosis. Stroke 1996;27;1724-30.
6. Parakh R, Somaya A, Todi SK, Iyengar SK. Consensus Development Recommendations for the Role of LMWHs in Prophylaxis of Venous Thromboembolism : An Indian Perspective. SUPPLEMENT OF JAPI _ JANUARY 2007 _ VOL. 55.
7. Incidence of venous thromboembolism: a community-based study in Western France. Thromb Haemost. 2000 May ;83 (5):657-60 10823257.
8. Wells PS, Rodger M. Diagnosis of pulmonary embolism: when is imaging needed? Clin Chest Med2003:24:13-28.
9. Padmavati S, Gupta S, Singh B.A clinical study of 44 cases of hemiplegia in adult women. Neurol India 1957;5:59-65.
10. Srinivasan K.Cerebral venous and arterial thrombosis in pregnancy and puerperium:a study of 135 patients. Angiology 1983;34:731-46.
11. Agarwal R, Gulati M, Mittal BR, Jindal SK.Clinical profile, diagnosis and management of patients with symptomatic PE, PGIMER Chandigarh. Original article. Indian J Chest Dis Allied Sci 2006;48:111-114.
12. Nicolaides AN, Irving D. Clinical factors and the risk of deep venous thrombosis. In: Nicolaides A, editor. Thromboembolism Etiology. Advances in Prevention and Management. Baltimore, MD: University Park Press; 1975: 193–204.
13. Gillum RF. Pulmonary embolism and thrombophlebitis in the United States, 1970–1985. Am Heart J. 1987; 114: 1262–1264
14. Gjores JE. The incidence of venous thrombosis and its sequelae in certain districts in Sweden. Acta Chir Scand. 1993; 111 (Suppl 206): 16–24.
15. Ten Cate-Hoek AJ, Prins MH. Low molecular weight heparins in cancer Management and prevention of venous thromboembolism in patients with malignancies. [Epub ahead of print] Thromb Res. 2007 Nov 7.
16. Margot Tesselaar, ET, Susanne Osanto, Department of Clinical Oncology, Leiden University Medical Center, The Netherlands .Current Opinion in Pulmonary Medicine. 13(5):362-367, September 2007.
17. TAHRI A, El Hattaoui M,Charei N, El Belghiti M, Mahmal L, Tahiri F, Bouras N. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007: 19672.
18. Farmer RD, Lawrenson RA, Thompson CR, Kennedy JG, Hambleton IR. Population-based study of risk of venous thromboembolism associated with various oral contraceptives. Department of Public Health and Primary Care, Charing Cross and Westminster Medical School, University of London, Chelesa, UK.Lancet,1997 Jan 11;349(9045):83-88.
19. Pillai Lalitha V, Ambike Dhananjay P, Nirhale Satish, Husainy S M K, Pataskar Satish. Cerebral venous thrombosis: An experience with anticoagulation with low molecular weight heparin. Critical Care Department, Lokmanya Hospital, Chinchwad, Pune, India. IJCCM 2005;9:14-18.
20. Petri, M. Epidemiology of the antiphospholipid antibody syndrome. J Autoimmun. 2000; 15: 145–151.
21. Schved JF, Dupuy-Fons C, Biron C, et al. A prospective epidemiological study on the occurrence of antiphospholipid antibody: the Montpellier Antiphospholipid (MAP) Study. Haemostasis. 1994; 24: 175–182.
22. Bick RL. Hypercoagulability and thrombosis. Med Clin North Am. 1994; 78: 635–665.
23. Carine J.M. Doggen; Nicholas L. Smith; Rozenn N. Lemaitre; Susan R. Heckbert; Frits R. Rosendaal; Bruce M. Psaty. Serum Lipid Levels and the Risk of Venous Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology:Volume24(10)October 2004pp 1970-1975.
24. Larsen LF; Bladbjerg EM; Jespersen J; Marckmann P. Effects of dietary fat quality and quantity on postprandial activation of blood coagulation factor VII. Arterioscler Thromb Vasc Biol (United States) Nov 1997, 17 (11) p2904-9.
25. Dormont D, Axionnat R et al. MRI in cerebral venous thrombosis. J Neuroradiology 1994; 21 (2): 81-99.
26. Padley SPG.Lung scintigraphy vs spiral CT in the assessment of pulmonary emboli.Br J Radiol 2002:75:5-8.
27. Linn BJ, Mazza JJ, Friedenberg WR. Treatment of venous thrombotic disease. Postgrd. Med. 1988 79(6): 171-80.
28. South path S.A. thrombolytic therapy for venous thrombosis and pulmonary embolism. Baillieres clin hematol 1998. 11(3): 663-73.
29. Fattahi O.H. Thrombolytic Therapy for Deep Vein Thrombosis and Pulmonary Embolism. Shiraz E-Medical Journal. October 2001, Vol. 2, No. 4.
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