IJCRR - Vol 07 Issue 15, August, 2015
INVASIVE LOBULAR BREAST CARCINOMA (ILC) IN AN ELDERLY MALE ON PROLONGED RANITIDINE THERAPY
Author: Srikantaiah Hiremath, Nikhil Nanjappa B. A.
Breast carcinoma in men is an exceedingly rare entity, contributing to 1% of all breast cancers , of which invasive lobular carcinoma (ILC) accounts for 1.5% . The average age at diagnosis is usually five years older compared to women [1, 3]. Although the exact aetiology remains unknown, hyperestrogenic states are attributed as the most likely cause . Men with family history of female breast cancer are at 2.5 times more increased risk when compared to those with no family history . Lobular histologic subtype of breast carcinoma in males is rare due to the lack of acini and lobules . Some medications, such as cimetidine
[7, 8] are thought to multiply the risk of male breast cancer because they induce a hyperestrogenic state. The authors report a rare case of ILC in a 75 year old man, with no known risk factors for breast cancer. However, he had a history of prolonged self-prescribed ranitidine use for dyspeptic symptoms. Although there isn’t enough evidence to suggest that ranitidine, like its predecessor cimetidine, may cause male breast cancer. The authors would like to draw attention to this possibility.
Keywords: Male breast carcinoma, Male breast cancer, Invasive lobular carcinoma males, Ranitidine induced male breast cancer
Srikantaiah Hiremath, Nikhil Nanjappa B. A.. INVASIVE LOBULAR BREAST CARCINOMA (ILC) IN AN ELDERLY MALE ON PROLONGED RANITIDINE THERAPY International Journal of Current Research and Review. Vol 07 Issue 15, August, 26-31
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