IJCRR - Vol 07 Issue 16, August, 2015
A STUDY OF HISTOPATHOLOGICAL CHANGES IN FALLOPIAN TUBES IN ECTOPIC PREGNANCY
Author: Richa Sharma, Dayanand S. Biligi
Aim: The study was conducted with the aim of studying histopathological changes in ectopic pregnancy in the fallopian tube and correlate them with clinical history.
Methodology: Fifty cases of tubal ectopic were studied retrospectively to compare the histopathological changes in the lining of fallopian tube. Routine haematoxylin and eosin stain with special stains were employed to study the sections. Ratio of ciliated to secretory cells was calculated. Associated inflammation and other pathology was also studied.
Results: Out of 50 cases studied majority of ectopics were on right side and presented at less than 8 weeks of gestation. Most common age group to be affected was between 28-32 yrs. Around 28 of cases had previous history of surgeries and 14% previous ectopic or abortions.
We also noted a significant degree of deciliation in the tubal lining with maximum number of cases showing deciliation in fimbrial ectopics. Significant number of cases showed association with salpingitis isthmica nodosa (22%) and inflammation was seen in three fourths of all cases.
Conclusion: The study highlights the association with deciliation in tubal ectopics and also the significant association with inflammation and abdominal interventions
Keywords: Ectopic, Deciliation, Fallopian tube, Salpingitis isthmica nodosa
Richa Sharma, Dayanand S. Biligi. A STUDY OF HISTOPATHOLOGICAL CHANGES IN FALLOPIAN TUBES IN ECTOPIC PREGNANCY International Journal of Current Research and Review. Vol 07 Issue 16, August, 54-58
1. Kumar Vinay, Abbas Abul K, Fausto Nelson, Aster Jon C. Robbins and Cotran Pathologic Basis of Disease. 8th edition. Elsevier. 1053-1054.
2. Vyas Priti S, Vaidya Pratibha. Epidemiology, diagnosis and management of ectopic pregnancy -an analysis of 196 cases. Bombay hospital journal.
3. Dutta DC. Textbook of Obstetrics. Edited by Hiralal Konar. 6thed.Central book agency .2004.179.
4. Young Barbara, Lowe James S, Stevens Alan, Heath John W. In: Wheater’s Functional histology. 5th ed. 367.
5. Young Barbara, Lowe James S, Stevens Alan, Heath John W. In: Wheater’s Functional histology. 5th ed. 368.
6. Rosai Juan. Female reproductive system. In: Rosai and Ackerman’s Surgical pathology. Vol 2. Ed.9. Elsevier Inc.2009.1636
7. Hendrickson MR, Kempson RL. Normal histology of the uterus and fallopian tubes. In : Sternberg S (ed): histology for pathologist, ed.2. Philadelphia, 1997; Lippincott-Raven: 879-928
9. Rosai Juan. Female reproductive system. In Rosai and Ackerman’s Surgical pathology. Vol 2. Ed.9. Elsevier Inc,2009: 1639
10. Burton JL, Lidbury EA, Gillespie AM, Tidy JA, Smith O, Lawry J, Hancock BW, Wells M. Over-diagnosis of hydatidiform mole in early tubal ectopic pregnancy. Histopathology 2001, 38: 409- 417.
11. Blaustein A, Shenker L, Vascular lesions of the uterine tube in ectopic pregnancy. Obstet Gynecol 1967, 30: 551-555.
12. Cole T, Corlett RC 1982. Chorionic ectopic pregnancy. Obstetrics and Gynecology 59: 63-68.
13. Nybo Anderson AM, Wohlfahrt J, Christens P, Olsen J, Melbye M.Maternal age and fetal loss:population based register linkage study. BMJ. 2000 Jun 24;320(7251):1708-12.
14. Heather Murray, Hanadi Baakdah, Trevor Bardell, Togas Tulandi. Diagnosis and treatment of ectopic pregnancy. CMAJ.2005 Oct11; vol173:no8: 905-12.
15. Hlavin GE, Ledoski LT, Bren JL.Ectopic pregnancy: an analysis of 153 patients. International Journal of Gynaecology and Obstetrics.1978;16:42-47.
16. De Cherney AH, Minkin MJ, Spangler S 1981a. Contemporary management of ectopic pregnancy. Journal of Reproductive Medicine 26:519-523.
17. F. Cunningham, Kenneth Leveno, Steven Bloom, John Hauth, Larry Gilstrap, Katharine Wenstrom. Williams Obstetrics. 22nd Edition. McGraw Hill Professional;2005:266.
18. Majhi AK, Roy N, Karmakar KS, Banerjee PK. Ectopic pregnancy – an analysis of 180 cases. J Indian Med Assoc.2007 Jun;105(6): 308, 310, 312.
19. Dhaiya N, Singh S, Kalra R, Sen R, Kumar S. Histopathological changes associated with ectopic tubal pregnancy. IJPSR,2011;Vol.2(4): 929-933.
20. Vasquez G, Winston RM, Brosens IA. Tubal mucosa and ectopic pregnancy. Br J Obstet Gynaecol. 1983 May;90(5): 468-74.
21. Homm RJ, Holtz G, Garvin AJ. Isthmic ectopic pregnancy and salpingitis isthmica nodosa. The American fertility society.1987;48: 756-60.
22. Dubuisson JB, Aubriot FX, Cardone V, Vaucher-Lavenu MC. Tubal causes of ectopic pregnancy. Fertil steril 1986; 46: 970-2.
26. Milman N1, Byg KE, Bergholt T, Eriksen L, Hvas AM. Body iron and individual iron prophylaxis in pregnancy--should the iron dose be adjusted according to serum ferritin? Ann Hematol. 2006 Sep;85(9):567-73. Epub 2006 May 30.
27. WHO. Iron deficiency anaemia: assessment, prevention, and control. A guide for programme managers. Geneva, Switzerland: World Health Organization, 2001. (WHO/NHD/01.3.)
28. Albonico M1, Stoltzfus RJ, Savioli L, Tielsch JM, Chwaya HM, Ercole E, Cancrini G. Epidemiological evidence for a differential effect of hookworm species, Ancylostoma duodenale or Necator americanus, on iron status of children. Int J Epidemiol. 1998 Jun;27(3):530-7.
29. Bakta, I. M., Wijana, D. P., and Sutisna, P. (1993). Hookworm infection and iron stores: a survey in a rural community in Bali, Indonesia. The Southeast Asian journal of tropical medicine and public health, 24(3), 501-504.