IJCRR - Vol 07 Issue 16, August, 2015
NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1 POLYMORPHISM SUSCEPTIBILITY TO MULTI DRUG RESISTANCE TUBERCULOSIS IN SOUTH INDIAN POPULATION: A CASE –CONTROL
Author: Rooth Vasantha M., G. Sudhakar, S. Sridevi
Aim: To know the association of NRAMP1 gene polymorphisms in MDR-TB Patients.
Methodology: Studies on NRAMP1 (Natural Resistance Associated Macrophage Protein1 or SLC11A1 revealed its function on macrophage activation and its association with infectious diseases. A case-control study was carried out to find the association of NRAMP1 gene with MDR-TB belonging to Visakhapatnam district of Andhra Pradesh, India. Genetic polymorphisms of NRAMP1 gene 3’UTR and 274 CT were analysed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism
Results: Significant statistical difference in the 3’UTR polymorphism between MDR-TB patients and healthy controls was observed. (P=0.001, OR=0.691,95%CI=0.077-6.208). But no significant association was found between the disease and 274 CT polymorphism (P>0.05).
Conclusion: Significant association of MDR-TB with 3’UTR polymorphism of NRAMP1 gene was identified, while no significant association was observed in 274CT polymorphism of NRAMP1 gene. Further study with large sample size is required to confirm the above results.
Keywords: NRAMP1, 3’UTR, 274CT, MDR-TB
Rooth Vasantha M., G. Sudhakar, S. Sridevi. NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1 POLYMORPHISM SUSCEPTIBILITY TO MULTI DRUG RESISTANCE TUBERCULOSIS IN SOUTH INDIAN POPULATION: A CASE –CONTROL
STUDY International Journal of Current Research and Review. Vol 07 Issue 16, August, 30-33
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