IJCRR - Vol 07 Issue 18, September, 2015
ALTERED LIPID PARAMETERS AND THEIR RELATIONSHIP WITH THYROID STIMULATING HORMONE IN SUBCLINICAL HYPOTHYROIDISM
Author: Bhavesh Sadariya, Suman Jain, Sonal Sogani
Background: Subclinical hypothyroidism (SCH) is a common thyroid disease affecting large population of the world. Diversit persists regarding the level of lipid parameters in patients with SCH.
Aim and Objectives: Aim of the present study was to estimate the level of lipid parameters in patients with subclinical hypothyroidism of Udaipur population and to see their relationship with TSH values.
Materials and Methods: The present study was conducted on 75 patients of subclinical hypothyroidism and 100 euthyroid. Fasting venous blood was collected from each participant and analyzed for thyroid profile (T3, T4 and TSH) and lipid parameters (total cholesterol-TC, triglyceride-TG and high density lipoprotein - HDL). Low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were calculated by using the Friedewald’s formula.
Results: Mean values of total cholesterol, triglyceride, LDL, VLDL, TC/HDL ratio and LDL/HDL ratio were significantly higher in SCH patients as compared to euthyroid. Mean of Serum HDL was also higher in SCH patients than euthyroid, but was not statistically significant. All lipid parameters were positively correlated with TSH values in SCH patients. Mean values of TC, TG, HDL, LDL and VLDL were higher in female patients as compared to male patients, but were not statistically significant.
Conclusion: Subclinical hypothyroidism is associated with dyslipidemia having raise in all lipid parameters, which may increases the risk of atherosclerosis and cardiovascular disease development.
Keywords: Hypothyroidism, Cardiovascular disease, Euthyroid, Subclinical, Dyslipidemia
Bhavesh Sadariya, Suman Jain, Sonal Sogani. ALTERED LIPID PARAMETERS AND THEIR RELATIONSHIP WITH THYROID STIMULATING HORMONE IN SUBCLINICAL HYPOTHYROIDISM International Journal of Current Research and Review. Vol 07 Issue 18, September, 01-05
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