Herbal Medicinal based Approach for Alzheimer Disease - A Mathematical Model

Arora Komal; Khurana Pooja; Kumar Deepak

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IJCRR - 13(21), November, 2021

Pages: 53-59

Herbal Medicinal based Approach for Alzheimer Disease - A Mathematical Model

Author: Arora Komal, Khurana Pooja, Kumar Deepak

Category: Healthcare

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Abstract:

Introduction: Due to the cases of more than 1 million (in India) and more than 80 million (worldwide) of Alzheimer disease, there is an immediate need of finding a cure for Alzheimer. Alzheimer disease, a type of dementia, is a neurodegenerative, progressive disease that gives rise to troubles and issues related to cognitive functions. It is not a normal part of ageing; though the greatest known risk factor is increasing age. Aim: Many treatments and many medications have been found but their efficacy to reach Blood-Brain Barrier and rate of beta-amyloid clearance is very low. Moreover, drawbacks like cost, drug resistance and side effects bringing down their success rate. Methodology: Considering the problem, this entry focuses on the alternate ways (herbal medicine) for Alzheimer cure by generalizing the mathematical model to investigate the effect of selected medicinal plants on the levels of amyloid-beta peptides, the characteristic hallmark of Alzheimer. Results: We have analyzed the effect of active compounds of five potent medicinal plants at different dosages i.e. 250 mg/ day, 500 mg/day, 750 mg/day and 1000 mg/day concerning time and found Withania somnifera as the best plant amongst five as it showed an effective decline in the beta-amyloid levels at 500 mg/day. We have also examined the ADME ( Absorption, Distribution, Metabolism and Excretion) profile of the selected plants using the Swiss ADME server which revealed no violation of Lipinski’s rule. Conclusion: This model can act as a utility model for formulating herbal-based compounds that increase the rate of amyloid-beta clearance from the brain by inhibiting aggregation of amyloid-beta with least/no side effects.

Keywords: Alzheimer disease, Amyloid-beta, Mathematical model, Herbal approach, Medicinal plant, Dosage

DOI URL: http://dx.doi.org/10.31782/IJCRR.2021.132109

Citation:

Arora Komal, Khurana Pooja, Kumar Deepak. Herbal Medicinal based Approach for Alzheimer Disease - A Mathematical Model International Journal of Current Research and Review. 13(21), November, 53-59

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A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

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