IJCRR - 8(1), January, 2016
COMPARISION OF THE ADVERSE EFFECTS PROFILE OF TRAVOPROST VS BRIMONIDINE/TIMOLOL IN PATIENTS OF PRIMARY OPEN ANGLE GLAUCOMA IN CENTRAL IDIAN POPULATION OF BHOPAL
Author: Rekha Mehani, Major V. K. Yadav, Rajnish Kumar Sankadia, Sarang Ghodki, Tanu Garg
Aim: To compare the adverse effects profile of Travoprost vs Brimonidine/Timolol in patients of Primary Open Angle Glaucoma(POAG) Methodology: In this randomized open label 12-week study, 70 patients were randomized to receive either 0.004% of Travoprost once daily in the evening or Brimonidine/Timolol combination twice daily. Their safety was concluded by monitoring their adverse effects during follow-up visits at 2, 4, 8, and 12 weeks. Results: Both treatment regimens were well tolerated during the period of study. Patients in the Travoprost group had a higher incidence of ocular irritation (30%), pigmentation of skin (33%), Thickening of eyelashes (39%) and hyperemia (36%) when compared to the Brimonidine/Timolol group which showed only ocular irritation (21%) and foreign body sensations (28%). Conclusions: The incidence of adverse effects were not significantly different between Travoprost and Brimonidine/Timolol therapy. Both had favourable safety profiles. However, Travoprost had more local side effects profile when compared to Brimonidine/Timolol.
Keywords: Beta blocker, Intraocular pressure, Prostaglandin analogue, ?2 agonist, Adverse effects
Rekha Mehani, Major V. K. Yadav, Rajnish Kumar Sankadia, Sarang Ghodki, Tanu Garg. COMPARISION OF THE ADVERSE EFFECTS PROFILE OF TRAVOPROST VS BRIMONIDINE/TIMOLOL IN PATIENTS OF PRIMARY OPEN ANGLE GLAUCOMA IN CENTRAL IDIAN POPULATION OF BHOPAL International Journal of Current Research and Review. 8(1), January, 51-54
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