IJCRR - 8(1), January, 2016
A STUDY OF THE CLINICAL PROFILE OF MALARIA AND ITS COMPLICATIONS
Author: Varsha Shirish Dabadghao, Veer Bahadur Singh, Dayal Sharma, Babu Lal Meena
Objectives: Malaria is one of the most widespread infection in the tropics, and also one of the most dangerous. There are four main types of malaria of which Plasmodium vivax and falciparum are common in India. There is a huge burden of disease and malaria is responsible for increased mortality and morbidity. This study was undertaken to evaluate clinical profile of P. vivax, falciparum and mixed malaria and to assess the complications of malaria as a whole and of each type. Methods: This was a cross sectional and observational study which was conducted on a hundred patients above age 14 years diagnosed with malaria. Diagnosis of malaria was made by gold standard method of peripheral blood smear examination and rapid tests. For categorical data, chi- square test was used. P < 0.05 was considered as a statistical significance at 95% confidence intervals. Results: In this study, there were 90% survivors and 10% of patients succumbed. Out of 90 survivors, 43 patients (47.7%) had some form of complicated malaria, whereas all patients who succumbed (10) had complicated malaria. The main complications were severe thrombocytopenia in 78% , significant jaundice (bilirubin> 3mg/dl) in 32% , hypotension with a systolic blood pressure (BP) of less than 70mmHg in 23% , renal impairment in 48% , cerebral malaria in 13%, acute respiratory distress syndrome (ARDS) IN 11%, severe anemia (hemoglobin < 5g/dl) in 10% and metabolic acidosis (bicarbonate < 15mmol/dl) in 5%. Conclusions: The complications seen in this study were mainly severe thrombocytopenia, hypotension, jaundice, renal impairment, cerebral malaria, ARDS, severe anemia and metabolic acidosis; severe thrombocytopenia and jaundice being the commonest, and. P. vivax accounted for more patients with hypotension and severe anemia than the other types of malaria.
Keywords: P. Vivax, P. Falciparum, Malaria, Complications
Varsha Shirish Dabadghao, Veer Bahadur Singh, Dayal Sharma, Babu Lal Meena. A STUDY OF THE CLINICAL PROFILE OF MALARIA AND ITS COMPLICATIONS International Journal of Current Research and Review. 8(1), January, 25-30
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