IJCRR - 8(1), January, 2016
IMPACT OF IMMUNOSUPPRESSIVE DRUGS ON SUDANESE RENAL TRANSPLANT RECIPIENTS INFECTED WITH INTESTINAL PARASITES
Author: Lienda Bashier Eltayeb, Hisham Ali Waggiallah
Objectives:Enteric parasites are important agents of disease throughout the world. And they increasingly have significant role in transplant candidates. Intestinal parasites that are asymptomatic before transplantation may become clinically significant under immunosuppressive treatment. In the other hand some immunosuppressive regimens has anti-parasitic effects that may result, in lower rates of parasitic infections. Methods: Stool samples were collected from renal transplant recipients attending Sudanese Kidney Association hospital and from a control group from January 2012 to April 2012. For the detection of parasites, fresh stool samples were separated into two samples; one was preserved in SAF fixative. From this sample smears were made for permanent stains. The second sample was examined by wet preparation. Modified trichrome staining method was used for permanent smears for microsporidia. Result: All (200) renal transplant recipients were on immunosuppressant drugs; (76.5%) of the study patients were on tacrolimus (prograf) therapy and only (23.5 %) were on cyclosporine A (CsA) therapy. Of the total patients on tacrolimus there (22.5%) were diagnosed with intestinal parasites and only (1.5%) of them were on Cyclosporine therapy. There was statistically significance between immunosuppressant agents and infection with intestinal parasites positivity in group I (P value= 0.019). All details are summarized in (Table 2). Multiple parasitic infections were observed in a total of 5/200 (2.5%) renal transplant recipients and 1/100(1%) controls (p < 0.05). G lamblia,and B. hominiswas frequently seen species as multiple infections in renal transplant recipients. Conclusion: Intestinal parasitic infections should not ignore in renal transplant recipients, So Cyclosporine therapy should be recommended as first line immunosuppressant drugs as well as prophylactic against wide range of parasitic diseases.
Keywords: Immunosuppressive drugs, Transplants, Intestinal parasites
Lienda Bashier Eltayeb, Hisham Ali Waggiallah. IMPACT OF IMMUNOSUPPRESSIVE DRUGS ON SUDANESE RENAL TRANSPLANT RECIPIENTS INFECTED WITH INTESTINAL PARASITES International Journal of Current Research and Review. 8(1), January, 20-24
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