IJCRR - 8(1), January, 2016
CORRELATION OF DISEASE DURATION, SMOKING PACK YEARS AND FEV1% PREDICTED WITH BAEP PARAMETERS IN PATIENTS OF COPD
Author: Rupali Parlewar, Rubiya Shaikh
COPD is a progressive disease associated with an amplified chronic inflammatory response to noxious particles or gases in the airways and lungs. It is characterized by airflow limitation that is not fully reversible. Long term exposure to lung irritants that damages the lungs and airways usually is the cause of COPD. Worldwide, the most commonly encountered risk factor for COPD is tobacco smoking. The early detection of auditory impairment can be possible by recording of BAEP in patients of COPD. Study includes 100 individual, all males with the age group of 40-60 yrs. were divided in two groups, study group (n=50) and controls (n=50). Study group includes patients of COPD, as per gold criteria and those had a duration of COPD for more than 5 years with stable course of disease. Controls are age & sex matched normal healthy adults. Spirometry was done in patients to confirm the diagnosis of COPD and the severity of airflow limitation. And BAEP recording was done. Latencies of wave I, II, III, IV, V and Interpeak latencies I-III, III-V, I-V of right ear had a statistically non-significant positive correlation with disease duration. There were increase in right ear latencies of wave I, II, III, IV, V and Interpeak latencies of I-III, III-V, I-V along with increase in smoking pack years indicating a positive correlation with p value <0.05 showing a statistical significance. Also statistical significant (p value <0.05) negative correlation between post-bronchodilator FEV1% predicted value and right ear latencies of wave I, II, III, IV, V &Interpeak latencies of I-III, III-V, I-V ; indicating prolongation of latencies of BAEP with reduction in FEV1% predicted. The progressive chronic hypoxemia leads to development of tissue hypoxia and decreases the cerebral perfusion; also it slows the nerve conduction in auditory pathways which causes prolongation of latency. The contents of tobacco smoke in addition to hypoxemia lead to hypoxia. Therefore smoking pack years and decreased FEV1% predicted value definitely have impact on BAEP.
Keywords: BAEP, Latencies, Interpeak latencies, FEV1 % predicted value, Smoking pack years, Disease duration, Hypoxia
Rupali Parlewar, Rubiya Shaikh. CORRELATION OF DISEASE DURATION, SMOKING PACK YEARS AND FEV1% PREDICTED WITH BAEP PARAMETERS IN PATIENTS OF COPD International Journal of Current Research and Review. 8(1), January, 09-15
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