mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells

Alkhansa Mahmoud; Maria Teresa Mancuso; Barbara Tanno; Md Zuki Abu Bakar; Hazilawati Hamzah; Mohd Hezmee Mohd Noor

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IJCRR - 13(6), March, 2021

Pages: 09-13

mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells

Author: Alkhansa Mahmoud, Maria Teresa Mancuso, Barbara Tanno, Md Zuki Abu Bakar, Hazilawati Hamzah, Mohd Hezmee Mohd Noor

Category: Healthcare

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Abstract:

Background: Breast cancer is one of the most common types of cancer and heterogeneous disease. Somatostatin receptors (SSTRs) are expressed in normal and tumour tissues including breast cancer cells. Objective: The aim of this study to evaluate the expression of SSTRs subtypes 1 – 5 in MCF7 and MDA-MB231 human breast cancer cell lines and compare the levels between two cells. Methods: The detection of mRNA expression levels of SSTRs in MCF7 and MDA-MB231 was performed using quantitativepolymerase chain reaction (qPCR). Results: SSTR1, 2, 3 and 4 mRNA levels were significantly higher in MDA-MB-231 about MCF-7. The expression of SSTR 4 mRNA was highest in MDA-MB231 and MCF-7 cell lines, however, SSTR3 mRNA was least expressed in both cell lines. Conclusion: SSTRs subtypes (1 – 5) were expressed in both MDA-MB231 and MCF7 cells. However, the levels of expression differ between both cell lines.

Keywords: Breast cancer, Cell lines, Somatostatin receptors and mRNA expression

DOI URL: http://dx.doi.org/10.31782/IJCRR.2021.13601

Citation:

Alkhansa Mahmoud, Maria Teresa Mancuso, Barbara Tanno, Md Zuki Abu Bakar, Hazilawati Hamzah, Mohd Hezmee Mohd Noor. mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells International Journal of Current Research and Review. 13(6), March, 09-13

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A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

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