IJCRR - 8(3), February, 2016
4'-THIODNA: UNEXPECTED BEHAVIOUR
Author: Mohamed I. Elzagheid
This viewpoint briefly discusses the impact of 4’-thiosubstitution on oligonucleotides behaviour. The study in the reviewed articles has shown unexpected A-form formation, and unexpected RNA-like behaviour of the 4’-thioDNA. This has been confirmed by the unexpected interaction of 4’-thioDNA with Lividomycin A, a RNA major groove binder, and by resistance to cleavage by DNase I, which is a DNA-specific endonuclease. 4’-ThioDNAwas also recognized by RNase V1 which is a RNA-specific endonuclease. These all findings will trigger the main focus of this viewpoint.
Keywords: Nucleic acids, ThioDNAs, 4’-ThioDNAs Structure and Properties
Mohamed I. Elzagheid. 4'-THIODNA: UNEXPECTED BEHAVIOUR International Journal of Current Research and Review. 8(3), February, 33-35
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