IJCRR - 8(3), February, 2016
Pages: 11-18
A COMPARATIVE STUDY OF CLONIDINE VERSUS TRAMADOL AS ADDITIVE TO BUPIVACAINE IN EPIDURAL ANAESTHESIA
Author: Mahesh Sutariya, Anand J. Amin, Miss Archana B. Behl
Category: Healthcare
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Abstract:
Introduction:
Pain is unpleasant sensory-emotional experience and one of the most feared symptoms experienced. Epidural anesthesia is safe, well practiced and inexpensive neuraxial block technique. Bupivacaine is commonly used for epidural anaesthesia. Researches have been conducted to identify different techniques and drugs that improve the quality of surgical anaesthesia, prolong the effect of bupivacaine and duration of postoperative analgesia. Objectives: To evaluate efficacy of epidural tramadol and clonidine used as adjuvant to bupivacaine. To compare onset and duration of sensory and motor blockade, quality of anaesthesia and duration of postoperative analgesia. Methods: A prospective, randomized placebo control study was undertaken, involving 90 patients from SMIMER hospital, Surat. Three groups were allotted 30 patients each and were given, bupivacaine+saline (Group A)/ Bupivacaine+tramadol (Group B)/ bupivacaine+clonidine (Group C). Results were recorded and analyzed. Results: The onset of sensory block was fastest in Group C. Total duration of sensory blockade was longest in Group B. Total duration of analgesia was longest in Group B, followed by Group C based upon Visual Analogue Scale. Both tramadol (Group B) and clonidine (Group C) prolong duration of analgesia and decrease requirement of post-operative analgesic doses and amongst them tramadol (Group B) is superior. Conclusion: Tramadol and clonidine both are used as adjuvant to bupivacaine for epidural anaesthesia and post-operative analgesia. Tramadol provides longer duration of post-operative analgesia without sedation and requirement of analgesic is less within 24 hours. Tramadol is useful because of its cost-effectiveness and easy availability.
Keywords: Pain, Pre-emptive anesthesia, Sensory blockade, Motor blockade
Citation:
Mahesh Sutariya, Anand J. Amin, Miss Archana B. Behl. A COMPARATIVE STUDY OF CLONIDINE VERSUS TRAMADOL AS ADDITIVE TO BUPIVACAINE IN EPIDURAL ANAESTHESIA International Journal of Current Research and Review. 8(3), February, 11-18
References:
1. Wall PD. The prevention of postoperative pain. Pain 1988;33:289–90.
2. Wu CT, Jao SW, Borel CO, Yeh CC, Li CY, Lu CH, Wong CS. The effect of epidural clonidine on perioperative cytokine response, postoperative pain, and bowel function in patients undergoing colorectal surgery. Anesth Analg 2004;99:502-09.
3. Ghatak T, Chandra G, Malik A, Singh D, Bhatia VK. Evaluation of the effect of magnesium sulphate vs. clonidine as adjunct to epidural bupivacaine. Indian Journal of Anaesthesia. 2010;54:308–13.
4. Davis M., Gendelman D. S., Tischler M. D., Gendelman P. M. 1982 A primary acoustic startle circuit: lesion and stimulation studies. J. Neurosci.; 2:791-805.
5. Upadhyay KK, Prabhakar T., Handa R., Beena H. Study of the efficacy and safety of clonidine as an adjunct to bupivacaine for caudal analgesia in children. Indian Journal of Aanaesthesia, 2005; volume 49(3): 199-201.
6. Anis Baraka, Samar Jabbour, Antoun Nader, Abla Sibai. A comparison of epidural tramadol and epidural morphine for post-operative analgesia. Can J Anaesth. Volume 40, Issue 4 , pp 308-13
7. Rodgers A, Walker N, Schug S et al. Reduction of post operative mortality and morbidity with epidural or spinal anaesthesia: Results from overview of randomised trials. Brit Med J. 2000;321:1493–97.
8. M De Kock, M.D., B Crochet, M.D., C Morimont, M.D., J-L Scholtes, M.D.; Intravenous or Epidural Clonidine for Intra- and Postoperative Analgesia. Anesthesiology 1993;79(3):525-31.
9. Wylie and Churchill Davidson: A practice of Anaesthesia, 7th edition. Edward Arnold publication. 608-13.
10. Gupta S, Raval D, Patel M, Patel N, Shah N. Addition of epidural Clonidine enhances postoperative analgesia: A doubleblind study in total knee- replacement surgeries. Anesthesia, Essays and Researches. 2010;4(2):70-74. doi:10.4103/0259- 1162.73510.
11. Huang Yuan-Shiou, Lin Liu-Chi, Huh Billy K. Epidural clonidine for postoperative pain after total knee arthroplasty: A doseresponse study. Anesth Analg. May 2007: Volume 104: Issue 5- pp 1230-1235.
12. Noha Sayed H. A comparative study between magnesium sulphate and clonidine as adjuvant to epidural anaesthesia in patients undergoing abdominal hysterectomyhy. Ain-Shams Journal of Anaesthesiology. 2011: 4: no. 3: 1-9.
13. Sterling K. textbook of Pharmacology and Physiology in Anaesthesia practice (Lippincott Williams and Wilkins) 4th edition. Cha-15 – (clonidine) antihypertensive drugs. 340-345. Cha-7, local anaesthesia. 179-207.
14. Shahid Khan and Mohammad Iqbal memon et al: caudal bupivacaine alone and bupivacaine-tramadol in children with hypospadias repair.JCPSP- J Coll Physici 2008. Vol. 18 (10). 601- 604.
15. Y. demiraran, B. Kocaman and R. y. Akman. A comparision of the postoperative analgesic efficacy of single dose epidural tramadol versus morphine in children. Brit J Anaesth. (October 2005) 95 (4): 510-513.
16. S. Prakash, R. Tyagi, A. R. Gogia, R. Shing, S. Prakash. Efficacy of three doses of tramadol with bupivacaine for caudal analgesia in paediatric inguinal herniotomy. Brit J Anaesth. 97(3): 385- 388 (2006).
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