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International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR DOI Prefix (CrossRef): 10.31782/2231-2196

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Abstract

IJCRR - 13(4), February, 2021

Pages: 83-90

Progressive Insights into the Pharmacological Importance of Isoquinoline Derivatives in Modern Therapeutics

Author: Kishor R. Danao, Pooja M. Malghade, Debarshi Kar Mahapatra, Meha N. Motiwala, Ujwala N. Mahajan

Category: Healthcare

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Abstract:

Isoquinoline (ISOQ) is a heterocyclic aromatic organic compound composed of a benzene ring fused to a pyridine ring, referred to as benzopyridines. The chemical formula is C9H7N with a molar mass of 129.162 g/mol. This ISOQ ring derives from the natural aromatic amino acid tyrosine. It is weak alkaline in nature but is more basic than quinoline. It appears as a yellowish oily liquid, having an unpleasant odour, hygroscopic when solid, has a density of 1.099 g/cm3, a melting point of 26°C to 28°C (79°F to 82°F), the boiling point of 242°C (468°F), and dipole moment of 2.49. In the preparation of this review article, a widespread examination of the published literature in varied pharmaceutical and medical databases such as PubMed, Google Scholar, etc. was fruitfully carried out and categorized consequently. The imperative review revealed the less known biological (anti-fungal, anti-Parkinsonism, anti-tubercular, anti-tumour, anti-glaucoma, anti-Alzheimer’s disease, anti-viral, anti-bacterial, anti-diabetic, anti-malarial, etc.) potentials of ISOQ (an important class of chemical compounds) and their synthetic derivatives. This knowledge will serve as a ready reference for the global researchers and will be very helpful or inspiring for the medicinal chemists or associated investigators in developing novel low-molecular-weight (LMW) inhibitors for pharmacotherapeutic applications.

Keywords: Isoquinoline, Derivatives, Pharmacology, Therapeutics, Targets, Inhibitors

 Citation:

Kishor R. Danao, Pooja M. Malghade, Debarshi Kar Mahapatra, Meha N. Motiwala, Ujwala N. Mahajan. Progressive Insights into the Pharmacological Importance of Isoquinoline Derivatives in Modern Therapeutics International Journal of Current Research and Review. 13(4), February, 83-90

References:

  1. Harris J, Pope WJ. Isoquinoline and the isoquinoline-reds. J Chem Soc 1922;121:1029-1033.

  2. Pozharskii AF, Soldatenkov AT, Katritzky AR. Heterocycles in life and society: an introduction to heterocyclic chemistry, biochemistry and applications. John Wiley & Sons; 2011.

  3. Katritzky AR, Pozharskii AF, Soldatenkov A. Heterocycles in Life and Society: An Introduction to Heterocyclic Chemistry, Biochemistry and Applications. John Wiley & Sons; 2011.

  4. Khan F, Qidwai T, Shukla RK, Gupta V. Alkaloids Derived from Tyrosine: Modified Benzyltetrahydroisoquinoline Alkaloids. Nat Prod 2013;8(3):405-460.

  5. Gilchrist TL. Heterocyclic chemistry. Addison Wesley Longman, UK; 1997.

  6. O'Neil, Maryadele J. The Merck Index. Whitehouse Station; 2001.

  7. Quinoline. Encyclopedia Britannica. 1911;11(22): 758-759.

  8. Ram VJ, Sethi A, Nath M, Pratap R. The Chemistry of Heterocycles: Nomenclature and Chemistry of Three to Five Membered Heterocycles. Elsevier; 2019.

  9. Braude EA, Nachod FC. Determination of organic structures by physical methods. Elsevier; 2013.

  10. Jie JL. Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications. Springer Science Ltd.; 2014.

  11. Wang Y, Patil P, Kurpiewska K, Kalinowska-Tluscik J, Do?mling A. Diverse Isoquinoline Scaffolds by Ugi/Pomeranz–Fritsch and Ugi/Schlittler–Mu?ller Reactions. Org Lett 2019;21(10):3533-3537.

  12. Marella A, Tanwar OP, Saha R, Ali MR, Srivastava S, Akhter M, Shaquiquzzaman M, Alam MM. Quinoline: A versatile heterocyclic. Saudi Pharm J 2013;21(1):1-2.

  13. Pandeya SN, Tyagi A. Synthetic approaches for quinoline and isoquinoline. ChemInform 2012;43(3):53­61-5365.

  14. Lass?Flörl C. The changing face of epidemiology of invasive fungal disease in Europe. Mycoses 2009;52(3):197-205.

  15. Palomino JC, Martin A. Drug Resistance Mechanisms in Mycobacterium tuberculosis. Antibiotics 2014,3(3):317-340.

  16. Kakhkia S, Shahosseinia S, Zarghi A. Pyrrolo[2,1-a] Isoquinoline-Based Derivatives as New Cytotoxic Agents, Iranian J Pharm Res 2016;15(4):743-751.

  17. Heravi M, Nazari N. Bischler-Napieralski reaction in total synthesis of isoquinoline-based natural products. An old reaction, a new application. Curr Org Chem 2015;19(24):2358-2408.

  18. Pashev AS, Burdzhiev NT, Stanoeva ER. Synthetic Approaches toward the Benzo [a] quinolizidine System. A Review. Org Prep Proced Int 2016;48(6):425-467.

  19. Awuah E, Capretta A. Strategies and synthetic methods directed toward the preparation of libraries of substituted isoquinolines. J Org Chem 2010;75(16):5627-5634.

  20. Zheng B, Trieu TH, Li FL, Zhu XL, He YG, Fan QQ, Shi XX. Copper-Catalyzed Benign and Efficient Oxidation of Tetrahydroisoquinolines and Dihydroisoquinolines Using Air as a Clean Oxidant. ACS Omega 2018;3(7):8243-8252.

  21. Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 2007;20(1):133-163.

  22. Negri M, Martins M, Henriques M, Svidzinski TI, Azeredo J, Oliveira R. Examination of potential virulence factors of Candida tropicalis clinical isolates from hospitalized patients. Mycopathologia 2010;169(3):175-182.

  23. Baron S. Alphaviruses (Togaviridae) and Flaviviruses (Flaviviridae)--Medical Microbiology. University of Texas Medical Branch at Galveston; 1996.

  24. Borg-von ZM, Kunz L, Ruchel R, Reichard U, Weig M, Gross U. Epidemiology and antifungal susceptibilities of Candida spp. to six antifungal agents. Antimicrob Chemother 2007;60:424–428.

  25. Siwek A, Stefa?ska J, Dzitko K, Ruszczak A. Antifungal effect of 4-arylthiosemicarbazides against Candida species. Search for molecular basis of antifungal activity of thiosemicarbazide derivatives. J Mol Model 2012;18(9):4159-4170.

  26. Surikova OV, Zachinyaeva AV, Mikhailovskii AG, Zachinyaev YV. Synthesis of 2, 2-dimethyl-1, 2-dihydrobenzo [f]-isoquinolines displaying antifungal activity. Chem Heterocycl Compd 2011;46(12):1471-1475.

  27. Cantrell CL, Dayan FE, Duke SO. Natural products as sources for new pesticides. J Nat Prod 2012;75(6):1231-1242.

  28. Walton JN. Brain's Diseases of the Nervous System. Oxford: Oxford University Press; 1977.

  29. Abe K, Saitoh T, Horiguchi Y, Utsunomiya I, Taguchi K. Synthesis and Neurotoxicity of Tetrahydroisoquinoline Derivatives for Studying Parkinson’s Disease. Biol Pharm Bull 2005;28(8):1355-1362.

  30. Ishiwata K, Koyanagi Y, Abe K, Kawamura K, Taguchi K, Saitoh T, Toda J, Senda M, Sano T. Evaluation of neurotoxicity of TIQ and MPTP and of parkinsonism?preventing effect of 1?MeTIQ by in vivo measurement of pre?synaptic dopamine transporters and post?synaptic dopamine D2 receptors in the mouse striatum. J Neurochem 2001;79(4):868-876.

  31. Nagatsu T. Isoquinoline neurotoxins in the brain and Parkinson's disease. Neurosci Res 1997;29(2):99-111.

  32. Bembenek ME, Abell CW, Chrisey LA, Rozwadowska MD, Gessner W, Brossi A. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1, 2, 3, 4-tetrahydro-, 3, 4-dihydro-, and fully aromatic isoquinolines. J Med Chem 1990;33(1):147-152.

  33. Antkiewicz-Michaluk L, W?sik A, Michaluk J. 1-Methyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine with the unexpected mechanism of action: new vistas of therapeutic application. Neurotox Res 2013;25(1):1-12.

  34. Storch A, Ott S, Hwang YI, Ortmann R, Hein A, Frenzel S, et al. Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson’s disease: studies using heterologous expression systems of the dopamine transporter. Biochem Pharmacol 2002;63(5):909-920.

  35. Smith I. Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence. Clin Microbiol Rev 2003;16(3):463-496.

  36. Andersen P. TB vaccines: progress and problems. Trends Immunol 2001;22:160-168.

  37. Barnes DS. Historical perspectives on the aetiology of tuberculosis. Microb Infect 2000;2(4):431-440.

  38. Brosch R, Gordon SV, Marmiesse M, Brodin P, Buchrieser C, Eiglmeier K, Garnier T, Gutierrez C, Hewinson G, Kremer K, Parsons LM. A new evolutionary scenario for the Mycobacterium tuberculosis complex. Proc Natl Acad Sci 2002;99:3684-3689.

  39. Dookie N, Rambaran S, Padayatchi N, Mahomed S, Naidoo K. Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care. J Antimicrob Chemother 2018;73(5):1138-1151.

  40. Smets RJ, Torfs E, Lemière F, Cos P, Cappoen D, Tehrani KA. Synthesis and antitubercular activity of 1-and 3-substituted benzo [g] isoquinoline-5, 10-diones. Org Biomol Chem 2019;17(11):2923-2939.

  41. Jain S, Chandra V, Jain PK, Pathak K, Pathak D, Vaidya A. Comprehensive review on current developments of quinoline-based anticancer agent. Arabian J Chem 2019;12(8):4920-4946.

  42. Liu MC, Lin TS, Penketh P, Sartorelli AC. Synthesis and antitumor activity of 4-and 5-substituted derivatives of isoquinoline-1-carboxaldehyde thiosemicarbazone. J Med Chem 1995;38(21):4234-4243.

  43. Liu MC, Lin TS, Sartorelli AC Chemical and biological properties of cytotoxic alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones. Prog Med Chem 1995;32:1-35.

  44. Wang X, Zhang H, Chen X. Drug resistance and combating drug resistance in cancer. Cancer Drug Resist 2019;2:141-160.

  45. Janecka A, Wyr?bska A, Gach K, Fichna J, Janecki T. Natural and synthetic α-methylenelactones and α-methylenelactams with anticancer potential. Drug Discov Today 2012;17(11-12):561-572.

  46. Yang X, Yang S, Chai H, Yang Z, Lee RJ, Liao W, et al. A novel isoquinoline derivative anticancer agent and its targeted delivery to tumour cells using transferrin-conjugated liposomes. PLoS One 2015;10(8):e0136649.

  47. Yan Y, En D, Zhuang Z, Guo Y, Liao WW. Synthesis of densely functionalized α-methylene γ-butyrolactones via an organocatalytic one-pot allylic-alkylation–cyclization reaction. Tetrahedron Lett 2014;55(2):479-482.

  48. Bollini M, Casal JJ, Alvarez DE, Boiani L, González M, Cerecetto H, et al. New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: biological evaluation and structure–activity relationships. Bioorg Med Chem 2009;17(4):1437-1444.

  49. Liao WL, Li SQ, Wang J, Zhang ZY, Yang ZW, Xu D, et al. An efficient and facile method for the synthesis of benzimidazoisoquinoline derivatives via a multicomponent reaction. ACS Comb Sci 2016;18(1):65-69.

  50. Bailly C. Anticancer Properties of Lamellarins. Mar Drugs 2015;13(3):1105–1123.

  51. Kakhki S, Shahosseini S, Zarghi A. Design and synthesis of pyrrolo [2, 1-a] isoquinoline-based derivatives as new cytotoxic agents. Iranian J Pharm Res 2016;15(4):743.

  52. Facompré M, Tardy C, Bal-Mahieu C, Colson P, Perez C, Manzanares I, et al. A novel potent inhibitor of topoisomerase I. Cancer Res 2003;63(21):7392-7399.

  53. Jiang M, Huang O, Zhang X, Xie Z, Shen A, Liu H, et al. Curcumin induces cell death and restores tamoxifen sensitivity in the antiestrogen-resistant breast cancer cell lines MCF-7/LCC2 and MCF-7/LCC9. Molecules 2007;18:701-720. 

  54. Yue W, Wang JP, Li Y, Fan P, Liu G, Zhang N, Conaway M, Wang H, Korach KS, Bocchinfuso W, Santen R. Effects of estrogen on breast cancer development: Role of estrogen receptor-independent mechanisms. Int J Cancer 2010;127(8):1748-1757.

  55. Kakhki S, Shahosseini S, Zarghi A. Design, synthesis and cytotoxicity evaluation of new 2-aryl-5, 6-dihydropyrrolo[2, 1-a]isoquinoline derivatives as topoisomerase inhibitors. Iran J Pharm Res 2014,13:71-77.

  56. Kingman S. Glaucoma is the second leading cause of blindness globally. Bull World Health Org. 2004;82:887-888. 

  57. Feng Y, Lograsso PV, Defert O. Rho kinase (ROCK) inhibitors and their therapeutic potential. J Med Chem 2016;59(2):269–300.

  58. Oliveira RG, Guerra FS, Mermelstein CD, Fernandes PD, Bastos IT, Costa FN, et al. Synthesis and pharmacological evaluation of novel isoquinoline N-sulphonylhydrazones designed as ROCK inhibitors. J Enzyme Inhib Med Chem 2018;33(1):1181-1193.

  59. Tanna AP, Johnson M. Rho-kinase inhibitors as a novel treatment for glaucoma and ocular hypertension. Ophthalmology 2018;125(11):1741-1756.

  60. Wang SK, Chang RT. An emerging treatment option for glaucoma: Rho kinase inhibitors. Clin Ophthalmol 2014;8:883-890. 

  61. Mérour JY, Buron F, Plé K, Bonnet P, Routier S. The azaindole framework in the design of kinase inhibitors. Molecules. 2014;19(12):19935-19979.

  62. Angeli A, Chiaramonte N, Manetti D, Romanelli MN, Supuran CT. Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators. J Enzyme Inhib Med Chem 2018;33(1):303-308.

  63. Lane CA, Hardy J, Schott JM. Alzheimer's disease. Eur J Neurol 2018;25:59–70.

  64. Rajmohan R, Reddy PH. Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer’s disease neurons. J Alzheimer's Dis 2017;57(4):975-999.

  65. Nordberg A, Ballard C, Bullock R, Darreh-Shori T, Somogyi M. A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer’s disease. Prim Care Companion CNS Disord 2013;15(2):PCC.12r01412.

  66. Anand R, Gill KD, Mahdi AA. Therapeutics of Alzheimer’s disease: Past, present and future. Neuropharmacology 2014;76:27–50.

  67. Ehret MJ, Chamberlin KW. Current practices in the treatment of Alzheimer disease: Where is the evidence after the phase III Trials. Clin Ther 2015;37:1604-1616.

  68. Lleo A. Current therapeutic option for Alzheimer’s disease. Curr Genom 2007;8:550-558.

  69. Kumar S. Dual inhibition of acetylcholinesterase and butyrylcholinesterase enzymes by allicin. Indian J Pharmacol 2015;47(4):444-446.

  70. Lane RM, Potkin SG, Enz A. Targeting acetylcholinesterase and butyrylcholinesterase in dementia. Int J Neuropsychopharmacol 2006;9:101-124.

  71. Giacobini E. Cholinesterase inhibitors: new roles and therapeutic alternatives. Pharmacol Res 2004;50:433-440.

  72. Bedard J, May S, Heurex L, Stamminger T, Chan L. Antiviral properties of a series of 1,6-naphthyridine and 7,8-dihydro isoquinoline derivatives exhibiting potent activity against human cytomegalovirus. Antimicrob Agent Chemother 2000;44:929-937.

  73. Chan L, Jin H, Stefanac T, Lavallée JF, Falardeau G, Wang W, Bédard J, et al. Discovery of 1, 6-naphthyridines as a novel class of potent and selective human cytomegalovirus inhibitors. J Med Chem 1999;42(16):3023-3025.

  74. Chan L, Jin H, Stefanac T, Wang W, Lavallée JF, Bédard J, et al. Isoquinoline-6-carboxamides as potent and selective anti-human cytomegalovirus (HCMV) inhibitors. Bioorg Med Chem Lett. 1999;9(17):2583-6.

  75. Galán A, Moreno L, Párraga J, Serrano Á, Sanz MJ, Cortes D, et al. Novel isoquinoline derivatives as antimicrobial agents. Bioorg Med Chem 2013;21(11):3221-3230.

  76. Galán A, Moreno L, Párraga J, Serrano Á, Sanz MJ, Cortes D, Cabedo N. Novel isoquinoline derivatives as antimicrobial agents. Bioorg Med Chem 2013;21(11):3221-3230.

  77. Sloop JC. Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress. J Chem 2017;2017.

  78. Nord C, Levenfors JJ, Bjerketorp J, Sahlberg C, Guss B, Öberg B, Broberg A. Antibacterial Isoquinoline Alkaloids from the Fungus Penicillium Spathulatum Em19. Molecules 2019;24(24):4616.

  79. Srivastava A, Talaue M, Liu S, Degen D, Ebright RY, Sineva E, et al. New target for inhibition of bacterial RNA polymerase:‘switch region’. Curr Opin Microbiol 2011;14(5):532-543.

  80. Seuring T, Archangelidi O, Suhrcke M. The economic cost of type 2 diabetes: a global systematic review. Pharmacoeconomics 2015;33:811-831.

  81. Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and in­sulin-resistant states. Diabetes 2006;55:2256-2264.

  82. Zhang H, Wei J, Xue R, Wu JD, Zhao W, Wang ZZ, et al. Berberine low­ers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolomics 2010;59:285-292.

  83. Yin J, Gao Z, Liu D, Liu Z, Ye J. Berberine improves glucose metabolism through induction of glycolysis. Am J Physiol Endocrinol Metab 2008;294:E148-E156.

  84. Xu M, Xiao Y, Yin J, Hou W, Yu X, Shen L, et al. Berberine promotes glucose consumption independently of AMP-activated protein kinase activation. PLoS One 2014;9(7):e103702.

  85. Ren G, Wang YX, Li YH, Song DQ, Kong WJ, Jiang JD. Structure-activity relationship of berberine derivatives for their glucose-lowering activities. Int J Clin Exp Med 2017;10(3):5054-5060.

  86. Cheng Z, Chen AF, Wu F, Sheng L, Zhang HK, Gu M, et al. 8, 8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models. Bioorg Med Chem 2010;18(16):5915-5924.

  87. Muñoz GD, Dudley GB. Synthesis of 1, 2, 3, 4-tetrahydroquinolines including angustureine and congeneric alkaloids. A review. Org Prep Proced Int 2015;47(3):179-206.

  88. Jacquemond-Collet I, Hannedouche S, Fabre N, Fourasté I, Moulis C. Two tetrahydroquinoline alkaloids from Galipea officinalis. Phytochemistry 1999;51(8):1167-1169.

  89. Pan WH, Xu XY, Shi N, Tsang SW, Zhang HJ. Antimalarial activity of plant metabolites. Int J Mol Sci 2018;19(5):1382.

  90. Anthony MP, Burrows JN, Duparc S, Moehrle J, Wells TN. The global pipeline of new medicines for the control and elimination of malaria. Malaria J 2012;11(1):316.

  91. Schlitzer M. Antimalarial drugs–what is in use and what is in the pipeline. Archiv der Pharm 2008;341(3):149-163.

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A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

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