IJCRR - Vol 08 Issue 04, February, 2016
SPECTRUM OF LESIONS IN URINARY BLADDER -A HISTOPATHOLOGICAL STUDY
Author: Pooja Y. Shah, Monika Nanavati, Ravi G. Patel, Hansa M. Goswami
Background: Diseases of the bladder, particularly inflammation (cystitis), constitute an important source of clinical signs and symptoms. Tumors of the bladder are an important source of both morbidity and mortality. Objectives: 1) To study the histopathological features of various lesions in bladder. 2) To study the frequency of different pathological lesions, particularly Papillary Urothelial Neoplasms in urinary bladder. Results: 35 cases of urinary bladder were received. Out of 35 patients, 27 were males and 8 were females with male to female ratio being 3.38:1.The spectrum of pathological lesions included inflammations, metaplastic lesions, cystic lesions and tumors. Out of 35 cases 12(34.28%) were Non neoplastic lesions and 23(65.71%) were Neoplastic lesions. Among the non neoplastic lesions cystitis (41.67%) was the most common finding. Others were non-specific inflammation due to various etiology, hydatid cyst, benign epithelial inclusion cyst and abscess. Most common age groups affected by the neoplastic lesions were 41-50 years and 61-70 years with male to female ratio being 2.29:1. Among the neoplastic lesions 19(82.60%) cases were of urothelial neoplasms, others being Squamous Cell Carcinoma, Poorly Differentiated Carcinoma with Neuroendocrine differentiation and Paraganglioma. Most common Urothelial neoplasm was Non invasive Papillary Urothelial Carcinoma, Low Grade (9 cases). Among all the bladder biopsies received there was no muscle layer in 3 cases (8.3%). Conclusions: Our study has revealed that the bladder tumors are the commonest lesions in the urinary bladder tissues received and Papillary Urothelial Neoplasms were the predominant tumor type.
Keywords: Bladder, Papillary urothelial neoplasms, Paraganglioma.
Pooja Y. Shah, Monika Nanavati, Ravi G. Patel, Hansa M. Goswami. SPECTRUM OF LESIONS IN URINARY BLADDER -A HISTOPATHOLOGICAL STUDY International Journal of Current Research and Review. Vol 08 Issue 04, February, 19-24
1. Vinay Kumar, Abbas AK, and Fausto N. The lower urinary tract and male genital system. Robbins and Cotran. Pathologic basis of disease. 9th Edition. Philadelphia:Saunders 2004; 1026-1036.
2. Matalka et al. Transitional cell carcinoma of the urinary bladder: a clinicopathological study. Singapore Med J 2008; 49(10): 791.
3. Hasan SM et al. Frequency of transitional cell carcinoma in local suburban population ofkarachi. JLUMHS 2007; 83-85.
4. Beltran AL et al. Infiltrating urothelial carcinoma. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. IARC Press: Lyon 2004; 93-109.
5. Al- Samawi AS, Aulaqi SM. Urinary bladder cancer in Yemen. Oman Med J 2013; 28: 337-40.
6. Laishram RS, Kipgen P, Laishram S, Khuraijam S, SharmaDC. Urothelial tumors of the urinary bladder in Manipur: ahistopathological perspective. Asia Pacifi c Journal of CancerPrevention. 2012; 13: 2477-9.
7. Viadya S, Lakhey M, KC S, Hirachand S. Urothelial tumors ofthe urinary bladder: a histopathological study of cystoscopicbiopsies. J Nepal Med Assoc 2013; 52: 475-8.
8. Kumar UM, Yelikar BR. Spectrum of lesions in cystoscopicbladder biopsies- a histopathological study. Al Ameen J MedSci 2012; 5: 132- 6.
9. Stepan A, Simionescu C, Margaritescu C, Ciurea R. Histopathological study of the urothelial bladder carcinomas.Current health Science Journal 2013; 39:147-150.
10. Islam AHMT, Mostafa SN, Rahman M, Nahar Z. Role of ultrasound in the evaluation of urinary bladder neoplasm with histopathological correlation. Journal of Teachers Association TAJ 2008; 21:155-9.
11. Nepal Med Coll J 2014; 16(1): 9-12 Cystoscopic bladder biopsies: A histopathological studyPudasaini S,1 Subedi N,2 Prasad KBR,1 Rauniyar SK,1 Joshi BR,2 Bhomi K K 2
12. Biswas RR, Mangal S, Guha D, Basu K, Karmakar D. Anepidemiological study of cases of urothelial carcinoma ofurinary bladder in a tertiary care centre. Journal of KrishnaInstitute of Medical Sciences 2013; 2: 82-8.
13. Gupta P, Jain M, Kapoor R, Muruganandham K,Srivastava A, Mandhani A.Impact of age and gender on the clinicopathological characteristics of bladder cancer. Indian J Urol 2009; 25: 207-10.
14. I. Tosoni .U. Wagner, G Sauter. MEG Coff et al. Clinical Significance of Inter Observer Differences in the Staging and Grading of Superficial Bladder Cancer. BJU International 2000;85:48- 53.
15. Peter J Bostrom, Bas W.G. Van Rhijn, Neil Fleshner et al. Staging and Staging Errors in Bladder Cancer. European Urology Supplements 2010;9:2-9.
16. Mahesh Kumar U and B.R. Yelikar, Spectrum of Lesions in Cystoscopic Bladder Biopsies: A Histopathological study. Al Ameen J Medical Sci 2012;5 (2):132-136.
17. Felix AS, Soliman AS, Khaled H et al. The changing patterns of bladder cancer in Egypt over the past 26 years. Cancer Causes and Control 2008;19: 421-9.
18. Eble JN, Sauter G, Epstein JI, Sesterhenn IA, editors. World Health Organization of tumors- tumors of the urinary system and male genital organs. IARC Press, Lyon, 2004.
19. The global status of schistosomiasis and its control , L. Chitsulo, D. Engels, A. Montresor, L. Savioli, Acta Tropica 77 (2000) 41–51.