IJCRR - Vol 08 Issue 04, February, 2016
A STUDY OF HEMATOLOGICAL PARAMETERS AND ANTHROPOMETRIC INDICATORS IN HYPERTENSIVE AND NORMOTENSIVE MALES
Author: Divya R., Ashok V.
Introduction: Hypertension is one of the factors associated with stroke, congestive heart failure, heart or kidney failure. Overweight and obesity are the two most key determinants of health that leads to adverse metabolic changes including increase in blood pressure. The cellular components of blood contribute to the viscosity and volume of blood, thus playing a vital role in regulating blood pressure. Objectives: To compare the hematological parameters and anthropometric indicators in hypertensive and normotensive males. Materials and Methods: This was a hospital based case control study which included 60 normal healthy male subjects and 60 hypertensive male subjects. Blood pressure was measured in supine position by mercury sphygmomanometer. Hematological indices were estimated using an autoanlayser. The data collected were entered and analyzed using software Statistical Package for the Social Science 16.0 (SPSS 16.0). Results and Discussion: The mean levels of hemoglobin and hematocrit were significantly lower in the hypertensive group compared to the normotensives in our study. The anthropometric measurement waist hip ratio, showed a statistically significant positive correlation with systolic blood pressure. Multiple regression analysis showed waist hip ratio, hemoglobin and hematocrit were significant predictors of systolic blood pressure. Conclusion: The present study concludes that Waist hip ratio, a simple and inexpensive anthropometric measurement can be used as a significant predictor of systolic blood pressure. Also monitoring of hematological indices like hemoglobin and hematocrit is essential in the prevention of development of cardiovascular complications in hypertension.
Keywords: Hypertension, Anthropometric indicators, Hematological indices, BMI, WHR
Divya R., Ashok V.. A STUDY OF HEMATOLOGICAL PARAMETERS AND ANTHROPOMETRIC INDICATORS IN HYPERTENSIVE AND NORMOTENSIVE MALES International Journal of Current Research and Review. Vol 08 Issue 04, February, 06-12
1. The seventh report of the Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. JAMA2003; 289:2560-71.
2. Jyotsna Singh. World Health Organisation. Global Health Statistics. India has low rates of hypertension reveals WHO study. New Delhi, DHNS: 2012.
3. Mohan V, Deepa M, Farooq S, Datta M, Deepa R. Prevalence, awareness and control of hypertension in Chennai-the Chennai Urban Rural Epidemiology Study(CURES-52). J Assoc Physicians India 2007; 55:326-32.
4. Fauci A, Branwald E, Kasper L, Larry L. Hypertensive vascular disease. In: Naomi DL, Gordon HW eds. Harrison’s principles of internal medicine. 17th ed. Newyork: McGraw Hill Publishers: 1463-1480.
5. Deshmukh PR, Gupta S, Dongre A, Bharambe M, Maliye C. Relationship of anthropometric indicators with blood pressure levels in rural Wardha. Ind J Med Res 2006; 123:657-64.
6. Bose K, Ghosh A, Roy S, Gangopadhyay S. Blood pressure and waist circumference: an empirical study of the effcts of waist circumference on blood pressure among Bengaleemale jute workers of Belur, West Bengal, India. J Physiol Anthropol Appl Human Sci 2003; 22:169-73.
7. Shanthirani CS, Pradeepa R, Deepa R, Premalatha G, Saroja R, Mohan V. Prevalence and risk factors of hypertension in selected South Indian population – the Chennai Urban Population Study. J Assoc Physicians India 2003; 51:20-27.
8. Gupta R, Mehrishi S. Waist-hip ratio and blood pressure correlation in an urban Indian population. J Indian Med Assoc 1997; 95(7):412-415.
9. Cirillo, M Laurenzi, M Trevisan and J Stamler. Hematocrit, blood pressure, and hypertension. The Gubbio Population Study.Hypertension 1992; 20:319-326.
10. Chien S. Blood rheology in hypertension and cardiovascular disease. Cardiovasc Med 1977; 2:356-360.
11. Dan SJ, David C, Irwin J, Herbert J, Timothy C, Cecil M et al. Mean red cell volume as a correlate of blood pressure. Circulation 1996; 93: 1677.
12. Al-Muhana F, Larbi E, Ali A, Sultan A, Ateeq S Soweilem L et al. Haematological, lipid profile and other biochemical parameters in normal and hypertensive subjects among the population of the eastern province of Saudi Arabia. East Afr Med J 2006; 83(1):44-48.
13. Badaruddoza, Navneet K, Basanti B. Inter-relationship of waist-to-hip ratio (WHR), bodymass index (BMI) and subcutaneous fat with blood pressure among university-going Punjabi Sikh and Hindu females.International Journal of Medicine and Medical Sciences 2010; 2(1):5-11.
14. Corberand JX, Segonds C, Fontanilles AM, Cambus J, Fillola G, Laharrague P. Evaluation of the PENTRA 120 Hematology Analyzer in a university hospital setting. Clin Lab Haem 1999; 21:3-10.
15. Tambe B, Phadke V, Kharche S, Joshi R. Correlation of blood pressure with body mass index and waist to hip ratio in middle aged men. Internet Journal of Medical Update 2010; 5(2):26-30.
16. Bruschi G, Minari M, Bruschi E, Tacinelli L, Cavatorta A. Similarities of essential and spontaneous hypertension. Volume and number of blood cells. Hypertension 1986; 8:983-89.
17. Gordon RD, Küchel O, Liddle GW, Island DP. Role of the Sympathetic Nervous System in Regulating Renin and Aldosterone Production in Man. J Clin Invest 1967; 46(4):599–605.
18. Williams GH. The renin-angiotensin system and hypertension. Clin Exp Pharmacol Physiol Suppl 1982; 7:31-40.
19. Esler M, Julius S, Zwelfer A, Randall O, Harburg E, Gardiner H. Mild high–renin in essential hypertension: Neurogenic human hypertension. N Engl J Med 1977;296:405– 411.
20. Kes P, Jukic B, Kes V. The cardiorenal syndrome and erythropoietin. Acta Med Croatica. 2008; 62(1):21-31.
21. Silverberg DS, Wexler D, Iaina A, Schwartz D. The interaction between heart failure and other heart diseases, renal failure, and anemia. Semin Nephrol. 2006; 26(4):296-306.
22. Androne AS, Katz SD, Lund L. Hemodilution is common in patients with advanced heart failure. Circulation. 2003; 107:226–229.
23. Julius S. Corcoran Lecture. Sympathetic hyperactivity and coronary risk in hypertension. Hypertension. 1993; 21:886-893.
24. Hartz, A, Rupley D, Rimm A. The association of girth measurements with disease in 32,856 women. Am J Epidemiol 1984; 119:71-80.
25. Kabir M, Catalano KJ, Ananthnarayan S, Kim SP, Vancilters GW, Dea MK et al. Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Am J Physiol Endocrinol Metab 2005; 288(2):454-61.
26. Després J. Obesity and lipid metabolism: relevance of body fat distribution. Curr Opin Lipidol 1991;2(1):5- 15.
27. Karlsson C, Lindell K, Ottosson M, Sjostrom L, Carlsson B, Carlsson L. Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II. J Clin Endocrinol Metab 1998;83(11):3925-9.
28. Lee S, Bacha F, Gungor N, Arslanian SA. Waist circumference is an independent predictor of insulin resistance in black and white youths. J Pediatr 2006;148(2):188-94.
29. Hall JE, Jones DW, Kuo JJ, da Silva A, Tallam LS, Liu J. Impact of the obesity epidemic on hypertension and renal disease. Curr Hypertens Rep 2003;5(5):386-92.
30. Silverberg DS, Wexler D, Iaina A, Steinbruch S, Wollman Y, Schwartz D. Anemia, chronicrenal disease and congestive heart failure-the cardio renal anemia syndrome: the need for cooperation between cardiologists and nephrologists. Int Urol Nephrol 2006; 38(2):295- 310.
31. Beauloye V, Zech F, Tran HT, Clapuyt P, Maes M, Brichard SM. Determinants of early atherosclerosis in obese children and adolescents. J Clin Endocrinol Metab 2007; 92(8):3025-32.