ACCURACY OF SERUM URIC ACID IN PREDICTING COMPLICATIONS OF PRE-ECLAMPSIA

A. Ramana Priya; K. Jeyapriya; N. S. Kannan

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IJCRR - 8(5), March, 2016

Pages: 13-21

ACCURACY OF SERUM URIC ACID IN PREDICTING COMPLICATIONS OF PRE-ECLAMPSIA

Author: A. Ramana Priya, K. Jeyapriya, N. S. Kannan

Category: Healthcare

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Abstract:

Introduction: Pre-eclampsia, is a pregnancy-specific syndrome that occurs after mid gestation comprising of gestational hypertension with significant proteinuria. If not treated properly will lead to maternal and foetal complications. Aims: To study the accuracy of serum uric acid in predicting complications of pre-eclampsia and its effect on pregnancy outcome. Methods: Sixty pregnant women at term gestation with diagnosis of pre-eclampsia were included in our study after informed consent. For all patients included in the study all routine investigations including serum uric acid were done and recorded. All the patients were followed up until delivery and all maternal and foetal events were recorded. All complications of pre-eclampsia both maternal and foetal were statistically analysed to prove the predictive value of serum uric acid levels. Results: 18.3% of mothers were between the age group 18-21 years, 26.7% were between 22-25 years, 28.3% were between 26-29 years, and 26.7% were above 30 years. 83.4% of 60 mothers were primi para, 8.3% were para 2, and 8.3% were para 3. The difference in the first minute APGAR in the high risk and no risk category was not statistically significant at p value of 0.1798. The difference in the 5th minute APGAR in the high risk and no risk category was statistically significant at p value of 0.001. 4 out of 42 women (9.52%) with serum uric acid ≥6mg/dl had maternal complications and 7 out of 18 women with serum uric acid <6mg/dl had maternal complications (p value = 0.01) which is statistically significant. Considering less than 2.5 Kg as low birth weight, serum uric acid levels of more than 5.5 are associated with significant low birth weight (p value of 0.01) which is statistically significant. Conclusion: Our study with a sample size of 60 has proved that serum uric acid is statistically significant predictor (p value 0.01) of foetal complications of pre-eclampsia even though not of maternal complications (p value 0.42).

Keywords: Gestational hypertension, Eclampsia, HELLP syndrome, Maternal death, Intrauterine growth restriction, Foetal distress, Perinatal death

Citation:

A. Ramana Priya, K. Jeyapriya, N. S. Kannan. ACCURACY OF SERUM URIC ACID IN PREDICTING COMPLICATIONS OF PRE-ECLAMPSIA International Journal of Current Research and Review. 8(5), March, 13-21

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