IJCRR - Vol 08 Issue 07, April, 2016
DOES BODY MASS INDEX EFFECT NERVE CONDUCTION? A CROSS SECTIONAL STUDY
Author: Vineeta Chadha, Surendra S. Shivalkar
Aim: Body mass index (BMI) is an important parameter in gauging adiposity and obesity. Many studies have shown higher incidence of cardiovascular diseases especially coronary artery diseases in population with BMI greater than 25. (1) Studies also reveal median and ulnar nerve compression associated with an increasing incidence of higher BMI. (2) This study is an attempt to establish a relationship between median nerve conduction parameters and BMI in a population group from a metropolitan city in urban India. Methodology: In the present study the effect of Body Mass Index (BMI) on Median nerve motor and sensory conduction latency, amplitude and velocity was analysed in 90 healthy people in the age group of 18-30 years. Standardized protocol was followed while performing nerve conduction study in all the subjects. Results: This study shows that sensory nerve conduction amplitude decreases significantly with increase in BMI whereas the effect on other parameters is non-significant. Conclusion: This could be attributed to attenuation in conduction current by thicker subcutaneous tissue in persons with higher BMI. Median nerve latency and conduction velocity do not show significant decrease. This could be due to the fact that speed of conduction is same in the fastest conducting fibres irrespective of the adiposity..
Keywords: Nerve conduction velocity, Nerve conduction latency, Nerve conduction amplitude, Body mass index, Median nerve
Vineeta Chadha, Surendra S. Shivalkar. DOES BODY MASS INDEX EFFECT NERVE CONDUCTION? A CROSS SECTIONAL STUDY International Journal of Current Research and Review. Vol 08 Issue 07, April, 04-07
1. Romero-Corral A, Montori V M, Somers V K, Korinek J, Thomas R J, Allison T G, Mookadam F, Lopez-Jimenez F. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic review of cohort studies. Lancet. 2006 Aug 19;368(9536):666-78.
2. Landau ME, Barher KC, Campbell WW. Effect of body mass index on ulnar nerve conduction velocity, ulnar neuropathy at elbow and carpal tunnel syndrome. Muscle Nerve 2005; 32(3): 360–363.
3. Kimura J. Principles and pitfalls of nerve conduction studies. Ann Neurol 1984; 16: 415-429.
4. Chi-Ren Huang, Wen-Neng Chang, Hsueh-Wen Chang, NaiWen Tsai, and Cheng-Hsien; Effects of Age, Gender, Height, and Weight on Late Responses and Nerve Conduction Study Parameters; Lu Acta Neurol Taiwan 2009;18:242-249
5. Hasanzadeh P, Oveisgharan S, Sedighi N, Nafissi S. Effect of skin thickness on sensory nerve action potential amplitude. Clin Neurophysiol 2008; 119(8): 1824–1828.
6. Xuan Kong, Eugene A. Lesser, Frisso A. Potts, Shai N. Gozani. Utilization of Nerve Conduction Studies for the Diagnosis of Polyneuropathy in Patients with Diabetes: A Retrospective Analysis of a Large Patient Series. J Diabetes Sci Technol. 2008 March; 2(2): 268–274.
7. Buschbacher RM. Body mass index effect on common nerve conduction study measurements.Muscla Nerve, 1998 Nov; 21(11):1398-404
8. Misra U K, Kalita J. Clinical Neurophysiology, 2nd Edition: 1-128.
9. Misulis KE, Head TC. Nerve conduction study and electromyography. In: Pioli SF, editors. Essentials of Clinical Neurophysiology. 3rd Ed. Burlington: Butterworth-Heinemann; 2003. p.129-144.
10. Awang MS, Abdul lah JM, Abdul lah MR, Tharakan J, Prasad A, Husin ZA, Hussin AM, Tahir A, Razak SA. Nerve conduction study among healthy Malays . The influence of age, height, and body mass index on Median, ulnar , common peroneal and sural nerves. Malaysian Journal of Medical Sciences 2006; 13(2): 19–23.
11. Baqai HZ, Tariq M, Din AMU, Khawaja I, Irshad M. Sural nerve conduction; Age related variation studies in our normal population. The Professional 2001; 08(04): 439–444.
12. Sachin M. Pawar, Avinash B. Taksande and Ramji Singh. Effect of body mass index on parameters of nerve conduction study in Indian population. Indian J Physiol Pharmacol 2012; 56(1) : 88–93
13. Vessey MP, Villard-Mackintosh L, Yeates D. Epidemiology of carpal tunnel syndrome in women of childbearing age:findings in a large cohort study. Int J Epidemiol 1990;19:655-659.
14. Joao Aris Kouyoumdjian, Maria Da Penha Ananias Morita, Paulo Ricardo Fernando Rocha, Rafael Carlos Miranda, Gustavo Maciel Gouveia. Body Mass Index And Carpal Tunnel Syndrome. Arq Neuropsiquiatr 2000;58(2-A):252-256
15. Werner RA, Albers JW, Franzblau A, Armstrong TJ. The relationship between body mass index and the diagnosis of carpal tunnel syndrome. Muscle Nerve 1994;17:632-636.
16. Fonseca-Alaniz, M.H.; Takada, J.; Alonso-Vale, M.I.; Lima, F.B. Adipose tissue as an endocrine organ: From theory to practice. J. Pediatr. 2007, 83 (Suppl. 5), S192–S203.
17. Alba Fernandez-Sanchez, Eduardo Madrigal-Santillan, Mirandeli Bautista, Jaime Esquivel-Soto, Angel Morales-Gonzalez, Cesar Esquivel-Chirino, Irene Durante-Montiel, Graciela Sanchez-Rivera, Carmen Valadez-Vega and Jose A. MoralesGonzalez. Inflammation, Oxidative Stress, and Obesity. Int. J. Mol. Sci. 2011, 12, 3117-3132.