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IJCRR - 8(9), May, 2016

Pages: 48-52

LEPTIN: A DRIVING FORCE BEHIND THYROID PROBLEMS

Author: Singla Gesu, Bedi GK, Sandhu HS, Vij Chittranjan

Category: Healthcare

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Abstract:

Introduction: Apart from diabetes mellitus, thyroid dysfunction is one of the most common endocrine disorders encountered in adults, affecting up to 10% of the UK population Leptin is a 16kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
Aim: The aim of this study was to estimate thyroid hormones and Serum Leptin levels in patients with thyroid disorders and to find their correlation with each other.
Material and Methods: 50 diagnosed patients of thyroid disorders and 30 healthy controls were recruited in our study. Serum Leptin Levels, Serum T3, T4, TSH levels were estimated in both cases and controls using ELISA method.
Results: There was significant negative correlation between Serum Leptin and Serum T3. There was no significant but negative correlation between Serum Leptin and Serum T4. A very significant positive correlation was seen between Serum TSH and Serum Leptin levels.
Conclusion: Leptin problems are a driving force behind thyroid problems. Leptin triggers the decreased production of thyroid hormones. Improving leptin problems and losing weight will improve thyroid function.

Keywords: Leptin, Thyroid, TSH- Thyroid Stimulating Hormone, T4- Thyroxine, T3- Triiodothyronine

Citation:

Singla Gesu, Bedi GK, Sandhu HS, Vij Chittranjan. LEPTIN: A DRIVING FORCE BEHIND THYROID PROBLEMS International Journal of Current Research and Review. 8(9), May, 48-52

References:

1. Constanti A, Bartke A, Khardori R. The Thyroid Gland. In: Taylor and Francis. Basic Endocrinology for Students of Pharmacy and Allied Health Sciences. Harwood Academic Publishers 4th edn.Singapore: 2005;59-61.

2. Baig M, Karira KA, Ahmed A, Zaidi P, Niaz K, Kamal S. Serum Leptin level in Hyperthyroid Female Patients. Journal of Pakistan Medical Association. 2003;53(5):176-81.

3. Williams KW, Scott MM, Elmquist JK. From observation to experimentation: leptin action in the mediobasal hypothalamus. Am. J. Clin. Nutr. 2009;89(3):985S–990S.

4. Al-Shoumer KA, Vasanthy BA, Makhlouf HA, Al-Zaid MM. Leptin levels in Arabs with primary hyperthyroidism. Ann Saudi Med. 2000;20(2):113-8.

5. Friedman JM and Halaas JL. Leptin and the regulation of body weight in mammals. Nature Macmillan Publishers Ltd 1998;395:766.

6. AviBion Human Leptin ELISA Kit, User Manual. Available at:http://www.anibiotech.fi/anibiotech/pdfs/Orgenium-Leptin_ User Manual Rev1.09.pdf

7. Janson A, Karlsson FA, Micha-Johansson G, Bolme P, Brönnegård M, Marcus C. Effects of stimulatory and inhibitory thyrotropin receptor antibodies on lipolysis in infant adipocytes. J Clin Endocrinol Metab. 1995;80(5):1712-1712.

8. Reinehr T. Obesity and thyroid function. Mol Cell Endocrinol 2010;316:165-171.

9. Zimmermann-Belsing T, Brabant G, Holst JJ, Feldt-Rasmussen U. Circulating leptin and thyroid dysfunction. Eur J Endocrinol. 2003;149(4):257-71.

10. Yoshida T, Momotani N, Hayashi M, Monkawa T, Ito K, Saruta T. Serum leptin concentrations in patients with thyroid disorders. Clin Endocrinol (Oxf). 1998;48(3):299-302.

11. Tene Pérez CE, Revilla-Monsalve MC, Amato D, Escobedo de la Peña J, Galván R, Millán-Guerrero RO. Correlation between serum leptin levels and insulin sensitivity in diffuse toxic goiter. Endocr Res. 2004;30(1):19-27.

12. Azza M. Abdu-Allah, Riham G. Mahfouz, Seham A. Khodeer, Walid A. Shehab-Eldin, Mostafa El Nagar. Study of Resistin and Leptin in patients with Thyroid Dysfunction. Journal of American Science, 2011;7(3):569-76.

13. Ozata M, Ozisik G, Bingol N, Corakci A, Gundogan MA. The effects of thyroid status on plasma leptin levels in women. J Endocrinol Invest. 1998;21(6):337-41.

14. Hsieh CJ, Wang PW, Wang ST, Liu RT, Tung SC, Chien WY et al. Serum leptin concentrations of patients with sequential thyroid function changes. Clin Endocrinol (Oxf) 2002;57(1):29-34.

15. Iacobellis G, Ribaudo MC, Zappaterreno A, Iannucci CV, Leonetti F. Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clin Endocrinol (Oxf). 2005;62(4):487-91.

16. Siemi?ska L, Wojciechowska C, Kos-Kuda B, Marek B, Kajdaniuk D, Nowak M et al. Serum concentrations of leptin, adiponectin, and interleukin-6 in postmenopausal women with Hashimoto’s thyroiditis. Endokrynol Pol. 2010;61(1):112-6.

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