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International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR DOI Prefix (CrossRef): 10.31782/2231-2196

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Abstract

IJCRR - 8(9), May, 2016

Pages: 21-25

COMPARATIVE ANALYSIS OF SENSITIVITY AND SPECIFICITY OF CARDIAC SPECIFIC TROPONIN I AND CK-MB FOR DIAGNOSIS OF ST SEGMENT ELEVATION MYOCARDIAL INFARCTION

Author: Sandipkumar R. Patel, Hariom Sharma, Bhavika Vanani

Category: Healthcare

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Abstract:

Background: Study is designed to see correlation of cardiac specific Troponin I and Creatine Kinase-MB level to diagnose ST segment elevation myocardial infarction. Aim and Objectives: To access the diagnostic importance of cardiac specific Troponin I over Creatine Kinase-MB in patient of ST-segment elevation myocardial infarction. Materials and Methods: A comparative study was carried out in 100 patients, having ST segment elevation myocardial infarction. A group of 100 normal healthy individuals, age and sex matched from the same population served as controls. Troponin I and Creatine Kinase-MB levels were estimated in both the groups. Results: Results of present study shows that cardiac specific Troponin I and CK-MB levels were significantly higher in STEMI patients compared to healthy subjects with ‘p’ value of <0.0001. Pearson’s correlation test show positive correlation between Troponin I and CK-MB in STEMI patients. 17% of STEMI patients had normal CK-MB levels, but there Troponin I levels were elevated significantly. Conclusion: Troponin I level is more specific for confirming the diagnosis of acute myocardial infarction where CK-MB fails to do so.

Keywords: Troponin I, ST-segment elevation myocardial infarction (STEMI), Creatine Kinase – MB (CK-MB)

 Citation:

Sandipkumar R. Patel, Hariom Sharma, Bhavika Vanani. COMPARATIVE ANALYSIS OF SENSITIVITY AND SPECIFICITY OF CARDIAC SPECIFIC TROPONIN I AND CK-MB FOR DIAGNOSIS OF ST SEGMENT ELEVATION MYOCARDIAL INFARCTION International Journal of Current Research and Review. 8(9), May, 21-25

References:

1. Harrison’s Principles of Internal Medicine, Volume 1, 18th edition, chapter 245: ST-Segment Elevation Myocardial Infarction. McGraw Hill Education; p. 4082.

2. Sushma Pandey, Suresh Pandey, Purushottam Jhanwar, Anshul Jhanwar. A prospective study of Myocardial Infarction patients admitted in a tertiary care hospital of south-eastern Rajasthan. Int J Biol Med Res. 2012;3(2):1694-96.

3. Gary Ross, Frank N. Bever, Zi Uddin, Elaine M. Hockman. Troponin I sensitivity and specificity for the diagnosis of acute myocardial infarction. JAOA 2000;100:29-32.

4. Harper’s Illustrtaed Biochemistry, 28th Edition, chapter 7:Enzymes: Mechanism of Action, pp 127-28.

5. Jagannadha Rao Peela, Abdalla M. Jarari, Abdul Hai, Avinaash K. Rawal, Shoba Devi Kolla, Shakila Sreekumar et al. Cardiac Biomarkers: The Troponins and CK- MB. Ibnosina Journal of Medicine and Biomedical Sciences 2010;2(5):190-97.

6. Denis Xavier, Prem Pais, P J Devereaux, Changchun Xie, D Prabhakaran, K Srinath Reddy et al. Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data. Lancet 2008;371:1435–42.

7. S Joarder, M Hoque, M Towhiduzzaman, AF Salehuddin,N Islam, M Akter et al. Cardiac Troponin-I And CK-MB for Risk Stratification in Acute Myocardial Infarction (First Attack): A Comparative Study. Bangladesh J Med Biochem 2011;4(1):10- 15.

8. Allan S. Jaffe, Jan Ravkilde, Robert Roberts, Ulf Naslund, Fred S. Apple, Marcello Galvani et al. It’s Time for a Change to a Troponin Standard. Circulation 2000;102:1216-20.

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Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

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