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International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR DOI Prefix (CrossRef): 10.31782/2231-2196

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Abstract

IJCRR - 11(11), JUNE, 2019

Pages: 18-24

Anti-cancer effect of Gymnema sylvestre Leaf Extract against MG63, Human Osteosarcoma cell line - An in vitro analysis

Author: B. Packialakshmi, S. Raga Sowndriya

Category: Life Sciences

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Abstract:

Background: Gymnema sylvestre also known as ‘GURMAR’ is one of the important herbs in the Ayurvedic system of medicine and Indian proprietary medicines.
Objective: In the present investigation, phytochemical screening, free radical scavenging, anti-inflammatory and anti-cancer activities were evaluated in vitro in the aqueous extract from the leaves of Gymnema sylvestre (AGS).
Methods: Leaf samples were subjected with four different solvents (ethanol, acetone, ethyl acetate and distilled water) and the four extracts were screened for phytochemicals using different biochemical tests. AGS was subjected to fourier-transform infrared (FT-IR) spectroscopy to analyze its functional groups. Antioxidant activity of AGS was determined by measuring nitric oxide (NO) radical scavenging activity. The anti-inflammatory activity was studied using the inhibition of protein denaturation assay and anti-cancer activity was evaluated using MTT assay against MG63 cell lines.
Results: Phytochemical screening confirmed the presence of phytoconstituents like alkaloids, carbohydrates, triterpenoids, proteins, phenols and flavonoids. The FT-IR spectrum with different peak values revealed the presence of various functional compounds in AGS and it showed significant NO radical scavenging activity with the EC50 value of 401.66 μg/mL. AGS displayed strong anti-inflammatory activity (IC50 = 17.5 μg/mL). Moreover, AGS also exhibited significant dose-dependent anti-cancer activity against MG63 cell line and the IC50 value was 19.5 μg/mL.
Conclusion: The results indicate that Gymnema sylvestre can act as a promising free radical scavenger, anti-inflammatory and anticancer agent against MG63 human osteosarcoma cell lines. Hence, G. sylvestre can be used as natural antioxidants for preventing the oxidative stress related degenerative diseases..

Keywords: Anti-cancer, Anti-inflammatory, Free radicals, Gymnema sylvestre, MG63, Osteosarcoma

 Citation:

B. Packialakshmi, S. Raga Sowndriya. Anti-cancer effect of Gymnema sylvestre Leaf Extract against MG63, Human Osteosarcoma cell line - An in vitro analysis International Journal of Current Research and Review. 11(11), JUNE, 18-24

References:

REFERENCES

  1. Nair SS, Kavrekar V, Mishra A. Evaluation of in vitro anti diabetic activity of selected plant extracts. Int J Pharm Sci Invention 2013;2(4):12-19.

  2. Rikke Stamp Thorsen. Traditional medicine for the rich and knowledgeable. Challenging assumptions about treatment-seeking behaviour in rural and peri-urban. Health Policy and Planning 2015;31(3):314-324.

  3. Pragya T, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: An important medicinal plant. Biomed Research International 2014; Article ID 830285:18 pg.

  4. Chung KT, Wong TY, Wei CI, Huang YW, Lin Y. Tannins and human health: a review. Department of Microbiology and Molecular Cell Sciences, University of Memphis, TN 38152, USA. Crit Rev Food Sci Nutr 1998;38(6):421-64.

  5. Kumar G, Karthik L, Rao KVB. A review on pharmacological and phytochemical profile of calotropis gigantea Linn. Pharmacology online 2011;1:1-8.

  6. Austin DJ, Kristinsson KG, Anderson RM. The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance. Proc Natl Acad Sci 1999;96(3):1152.

  7. Reddy PS, Gopal GR, Sita GL. In vitro multiplication of Gymnema sylvestre R. Br, An important medicinal plant. Current Science 2004;75(8):843-845.

  8. Unni K K, Dahlin DC. Dahlin's bone tumors: general aspects and data on 11,087 cases. 1996;5th. Philadelphia, Penn, USA: Lippincott-Raven.

  9. Ritch-Kro EM, Turner NJ, Towers GH. Carrier herbal medicine: An evaluation of the antimicrobial and anti cancer activity in some frequently used remedies. J Ethnol Pharmacol 1996;52(3):151-156. 

  10. Catherine U, Tracee RA, Ethan B, Theresa DH, Ivo Foppa Paul Hammerness, Erica Rusie, Shaina Tanguay-Colucci, Sarah Taylor, Minney Varghese. An evidence-based systematic review of Gymnema (Gymnema sylvestre R. Br.) by the Natural Standard Research Collaboration. J Diet Suppl 2011;8(3):311-30.

  11. Elisha Solowey, Michal Lichtenstein, Sarah Sallon, Helena Paavilainen, Elaine Solowey,  Haya Lorberboum-Galsk. Evaluating medicinal plants for anticancer activity. The Sci World J 2014;Article ID 721402:12 pg.

  12. Edeoga HO, Okwu DE, Mbaebie BO. Phytochemical constituents of some Nigerian medicinal plants. Afr. J. Biotechnol 2005;4(7):685-688.

  13. Pustjens AM, Schols HA, Kabel MA, Gruppen H. Characterisation of cell wall polysaccharides from rape seed (Brassica napus) meal. Carbohydrate Polymers 2013;98:1650-1656.

  14. Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Viticult 1965; 16:44-158.

  15. Jia Z, Tang M, Wu J. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem 1999;64:555-599.

  16. Prieto P, Pineda M, Aguilar M. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex, specific application to the determination of vitamin E. Anal Biochem 1999;269:337-341.

  17. Govindarajan R, Rastogi S, Vijayakumar M, Shirwaikar A, Rawat AK, Mehrotra S, et al. Studies on the antioxidant activities of Desmodium gangeticum. Biol Pharm Bull 2003;26(10):1424-7.

  18. Sheelarani T, Gopal V, Seethalakshmi S, Chitra K. In vitro anti-inflammatory and anti-arthritic activity of selected medicinal plant. Int J Pharm Sci Rev Res 2014;28:162-163.

  19. Janki BP. An in vitro anticancer activity of aqueous extract of Triticum aestivum on hep2 human epithelioma of larynx cell line. World J Pharm Pharm Sci 2016;5(6):1520-1530.

  20. Parimala Devi B, Ramasubramaniaraja R. Pharmacognostical and antimicrobial screening of Gymnema sylvestre R.Br, and evaluation of Gurmar herbal tooth paste and powder, composed of Gymnema sylvestre R.Br, extracts in dental caries. Int J Pharm Bio Sci 2010;1(3):1-16. 

  21. Shi J, Nawaz H, Pohorly J, Mittal G, Kakuda Y, Jiang Y. Extraction of polyphenolics from plant material for functional foods-Engineering and Technology. Food Rev Int 2005;21(1):139-166.

  22. Seidel V. Initial and bulk extraction of natural products isolation. Met Mol Bio;2012;27-41.

  23. Tiwari B, Brunton N, Brennan C. Handbook of plant food phytochemicals 2013; Chichester: Wiley-Blackwell.

  24. Parag A, Pednekar BR. Antimicrobial and antioxidant potential with FT-IR analysis of Ampelocissus latifolia (roxb.) Planch leaves. Asian J Pharm Clin Res 2013;6(1): 67-73.

  25. Renuka B, Sanjeev B, Ranganathan D. Evaluation of phytoconstituents of Caralluma nilagirina by FTIR and UV-Vis spectroscopic analysis. J Pharm Phytochem  2016;5(2):105-108.

  26. Ragavendran P, Sophia D, Arul Raj C, Gopalakrishnan VK. Functional group analysis of various extracts of Aerva lanata (L.,) by FTIR spectrum. Pharmacologyonline 2011;1:358-364.

  27. Toyokuni S, Tanaka T, Kawaguchi W, Fang NR, Ozeki M, Akatsuka S, et al. Effects of the phenolic contents of Mauritian endemic plant extracts on promoter activities of antioxidant enzymes. Free Radic Res 2003;37:1215?24.

  28. Mungole AJ, Awati R, Chaturvedi A, Zanwar P. Preliminary phytochemical screening of Ipomoea obscura (L) -A hepatoprotective medicinal plant. Int J Pharm Tech Res 2010;2:2307-2312.

  29. Kahkonen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Kujala TS, et al. Antioxidant activity of plant extracts containing phenolic compounds. J Agric Food Chem 1999;47:3954?62.

  30. Mohamed Imran M, Mohamed Mahroop Raja M, Abdul Basith J, Asarudeen A. Determination of total phenol, flavonoid and antioxidant activity of edible mushrooms Pleurotus florida and Pleurotus eous. Int Food Res J 2011; 18:579-582.

  31. Middleton EJ, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673?751.

  32. Suresh S, Suriyavathana M. In vitro antioxidant potential of ethanolic extract of Anisomeles malabarica. Int Res J Pharm 2012;3:394?398.

  33. Qiao D, Ke C, Hu B, Luo J, Ye H, Sun Y, et al. Antioxidant activities of polysaccharides from Hyriopsis cumingii. Carbohyd Polym 2009;78:199?204.

  34. Grant NH, Alburn HE, Kryzanauskas C. Stabilization of serum albumin by anti-inflammatory drugs. Biochem Pharmacol. 1970;19:715-722.

  35. Chandra S, Chatterjee P, Dey P, Bhattacharya S. Evaluation of in vitro anti-inflammatory activity of coffee against the denaturation of protein. Asian Pac J Trop Biomed 2012;2:S178-S180.

  36. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Met 1983;65:55-63.

  37. Singh K, Deo B. Phytochemical evaluation and in vitro antioxidant activity of Gymnema sylvestre R.Br. J Med Plants Stud 2014;2(4):19-23.

  38. Boik J. Natural Compounds in Cancer Therapy, Oregon Medical Press, Minnesota, Minn, USA. (ISBN 0-9648280-1-4), Pharm Biol 2001;40(1):79-79.

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A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

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