IJCRR - 8(10), May, 2016
Pages: 16-19
INFLUENCE OF END STAGE RENAL DISEASE IN ALTERATION OF SOME TRACE ELEMENTS IN SUDANESE PATIENTS
Author: Kamal Eldin Ahmed Abdelsalam, Eshteag Mohammed Musllem
Category: Healthcare
[Download PDF]
Abstract:
Background: The role of trace elements in hemodialysis (HD) patients has not yet been clearly recognized. To minimize the health consequences of persistent HD, the levels of trace elements should be seriously adjusted.
Methods: The study was across-sectional conducted in Khartoum state ofSudan between August 2013 and April 2015 included 150patients with end stage renal disease treated with hemodialysis and 75 healthy volunteers as control group. Informed consent was assigned by each participant before taking the blood sample. All samples were analyzed for magnesium, zinc and copper. Results: Compared with healthy controls, in hemodialysis patients average serum levels of zinc (Zn) (663 μg/L) and copper (Cu) (797μg/L) were insignificantly different; however, magnesium (Mg) levels (38.61 mg/L) were significantly increased. According to sex of ESRD patients, serum Mg level was increased significantly in females, while insignificant changes were observed in Culevel. This study stated that Zn, Cu and Mg levels were significantly increased in elder patients more than younger ones. Zn, Cu and Mg were increased as increasing duration of dialysis, changing significantly in serum Zn and Cu. Conclusions: Our results concluded that in hemodialysis, aging, and sex have significant effects on Zn, Cu and Mg.
Keywords: Copper, ESRD, Hemodialysis, Magnesium, Zinc
Citation:
Kamal Eldin Ahmed Abdelsalam, Eshteag Mohammed Musllem. INFLUENCE OF END STAGE RENAL DISEASE IN ALTERATION OF SOME TRACE ELEMENTS IN SUDANESE PATIENTS International Journal of Current Research and Review. 8(10), May, 16-19
References:
1. Guo C H, Wang C L, Chen P C, Yang T C. Linkage of Some Trace Elements, Peripheral Blood Lymphocytes, Infl ammation, and Oxidative Stress in Patients Undergoing Either Hemodialysis or Peritoneal Dialysis. Perit Dial Int 2011, 31(5):583-91.
2. Ibrahim S, El Salamony O. Depression, quality of life and malnutrition-infl ammation scores in hemodialysis patients. Am J NepFhrol 2008, 28(5):784–791
3. Merlin T C, Mark C E, Paul Z. Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease. Nature Reviews Nephrology 2016, 12; 73–81
4. Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet 2013, 20:382 (9888):260-72.
5. Kalantar-Zadeh K, Streja E, Molnar M Z, Lukowsky L R, Krishnan M, Kovesdy C P. Mortality prediction by surrogates of body composition: an examination of the obesity paradox in hemodialysis patients using composite ranking score analysis. Am J Epidemiol 2012, 175:793– 803.
6. Li Z, An X, Mao H, Wei X, Chen J, Yang X, et al. Association between depression and malnutrition–infl ammation complex syndrome in patients with continuous ambulatory peritoneal dialysis. International Urology and Nephrology 2011, 43(3), pp 875-882
7. Kocha W, Karimc R, Marzeca Z, Miyatakac H, Himenoc S, Asakawa Y. Dietary intake of metals by the young adult population of Eastern Poland: Results from a market basket study. Journal of Trace Elements in Medicine and Biology 2016, 35; 36–42.
8. Francisco A L M, Rodríguez M. Magnesium - its role in CKD. Nefrologia 2013, 33(3):389-99.
9. Harari F, Åkesson A, Casimiro E, Lu Y, Vahte, M. Exposure to lithium through drinking water and calcium homeostasis during pregnancy: A longitudinal study. Environ Res. 2016, 29;147:1-7.
10. Tonelli M, Wiebe N, Hemmelgarn B, Klarenbach S, Field C, Manns B, et al. The Alberta Kidney Disease Network. Trace elements in hemodialysis patients: a systematic review and meta-analysis. BMC Medicine 2009,7:25
11. Ortega O, Rodriguez I, Cobo G, Hinostroza J, Gallar P, Mon C, et al. Lack of Infl uence of Serum Magnesium Levels on Overall Mortality and Cardiovascular Outcomes in Patients with Advanced Chronic Kidney Disease. ISRN Nephrology 2013, 2013:191786.
12. Bhogade R B, Suryakar A N, Joshi N G. Effect of Hemodialysis on Serum Copper and Zinc Levels in Renal Failure Patients. Eur J Gen Med 2013, 10(3):154-157
13. EL-Habibi E M, Bakr M A, Kamal N. Impact of haemodialysis on certain trace elements among patients suffering from end stage renal disease. Journal of American Science 2012, 8(12)
14. JoãoMatias P, Azevedo A, Laranjinha I, Navarro D, Mendes M, Ferreira C, et al. Lower Serum Magnesium Is Associated with Cardiovascular Risk Factors and Mortality in Haemodialysis Patients. Blood Purif 2014, 38:244-252
15. Kiziltas H, Ekin S, Erkoc R. Trace Element Status of Chronic Renal Patients Undergoing Hemodialysis. Biological Trace Element Research 2008, 124, 2, Page 103
16. Cunningham J, Rodríguez M, Messa P. Magnesium in chronic kidney disease Stages 3 and 4 and in dialysis patients. Clinical Kidney Journal 2012, 5 (Suppl. 1):i39-i51.
17. Mastrangelo A, Paglialonga F, Edefonti A. Assessment of nutritional status in children with chronic kidney disease and on dialysis. Pediatric Nephrology 2014, 29(8), pp 1349-1358.
18. Koca T, Berber A, Koca H B, Demir T A, Koken T. Effects of hemodialysis period on levels of blood trace elements and oxidative stress. ClinExpNephrol 2010, 14(5):463-8.
|