IMMUNOHISTOCHEMISTRY STUDY FOR HER-2/NEU EXPRESSION IN LESIONS OF UTERINE CERVIX

Pramod Sarwade; Sunita Patil; Rajan Bindu

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IJCRR - 8(13), July, 2016

Pages: 50-57

IMMUNOHISTOCHEMISTRY STUDY FOR HER-2/NEU EXPRESSION IN LESIONS OF UTERINE CERVIX

Author: Pramod Sarwade, Sunita Patil, Rajan Bindu

Category: Healthcare

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Abstract:

Objectives:
1. To study expression of HER-2/neu in lesions of uterine cervix by immunohistochemistry.
2. To correlate expression of HER-2/neu with histological type, grade and stage of cervical malignancy.
Methods: Total 50 cases were included during the period from October 2013 to October 2015. Immunohistochemical studies were done on formalin-fixed paraffin embedded tissue blocks with HER-2/neu antibody.
Results: Out of fifty cases, 10 cases (20%) of adenocarcinoma (ADC), 1 case (2%) of adenosquamous carcinoma, 4 cases (8%) of CIN, 3 cases (6%) of chronic cervicitis, 2 cases (4%) of chronic cervicitis with squamous metaplasia, 30 cases (60%) of squamous cell carcinoma of cervix (SCC). And It Amongst 9 cases of poorly differentiated SCC cases, 2 cases showed 1+ positivity, 2 cases showed 2+ positivity, 1 case showed 3+ positivity. Out of 16 cases of moderately differentiated SCC, 4 cases showed 1+ positivity, 4 cases showed 2+ positivity, 2 cases showed 3+ positivity. Among 5 cases of well differentiated SCC, 2 cases showed 1+ positivity. Out of 10 cases of adenocarcinoma of cervix, 2 cases of well differentiated adenocarcinoma showed 1+ positivity. Each 2 cases of moderately differentiated adenocarcinoma showed 1+ and 2+ positivity. Cervical carcinoma cases with involvement of lymph node and parametrium showed stronger HER-2/neu staining.
Conclusion: Higher HER-2/neu expression was noted in malignant lesion as compared to benign lesions. Stronger HER-2/neu expression was noted among higher stage tumors and those with parametrial and lymph node involvement.

Keywords: HER-2/neu expression, Immunohistochemistry, Cervical lesions

Citation:

Pramod Sarwade, Sunita Patil, Rajan Bindu. IMMUNOHISTOCHEMISTRY STUDY FOR HER-2/NEU EXPRESSION IN LESIONS OF UTERINE CERVIX International Journal of Current Research and Review. 8(13), July, 50-57

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