SYNTHESIS AND APPLICATIONS OF SUGAR FLUORINATED NUCLEOSIDES

Mohamed Ibrahim Elzagheid

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IJCRR - 8(13), July, 2016

Pages: 42-49

SYNTHESIS AND APPLICATIONS OF SUGAR FLUORINATED NUCLEOSIDES

Author: Mohamed Ibrahim Elzagheid

Category: Healthcare

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Abstract:

In this review, different methods that have been used for the synthesis of 1’-, 2’-, 3’-, 4’- and 5’-sugar fluorinated nucleosides and their analogous are presented and different fluorinating agents are listed. Highlighted examples of the sugar fluorinated nucleosides that make a great impact on chemistry, biochemistry, and drug discovery are also elaborated. This review has shown that introduction of a fluorine atom in different positions within the sugar structure of the nucleoside improves their reactivity and properties.

Keywords: Nucleosides synthesis and applications, Sugar fluorinated nucleosides, Fluorinating agents

Citation:

Mohamed Ibrahim Elzagheid. SYNTHESIS AND APPLICATIONS OF SUGAR FLUORINATED NUCLEOSIDES International Journal of Current Research and Review. 8(13), July, 42-49

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List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

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