IJCRR - 8(13), July, 2016
STUDY OF OXIDATIVE STRESS PARAMETERS IN TYPE-II DIABETES MELLITUS AND THEIR CORRELATION WITH BLOOD GLUCOSE LEVEL
Author: Prakash P. Malam1, Anand J. Amin2, Ashish C. Zala, Vipul M. Navadiya, Dhruv Patel, Dharna A. Patel
Objective: Increasing evidence has underlined the importance of oxidative stress in the pathophysiology of type-II diabetes mellitus and its contribution to the associated complications. However the correlation between oxidative stress parameters and blood glucose levels is not clearly understood.
Method: Present study was done to evaluate the oxidative stress parameters in patients with type-II diabetes mellitus and to check the correlation, if any, between these parameters and blood glucose. Plasma malondialdehyde and superoxide dismutase levels were measured in thirty type-II diabetes mellitus and thirty normotensive subjects. Fasting and post-prandial blood glucose correlation was analyzed by Pearson’s correlation.
Result: Enhanced oxidative stress was observed in type-II diabetes mellitus subjects as denoted by raised plasma malondialdehyde levels and reduced superoxide dismutase levels.
Conclusion: Plasma malondialdehyde correlated positively whereas superoxide dismutase showed negative correlation with blood glucose in type-II diabetes mellitus subjects. No significant correlation was observed between these parameters and blood glucose levels in normotensive controls.
Keywords: Oxidative stress, Type-II diabetes mellitus, Correlation, Malondialdehyde, Superoxide dismutase
Prakash P. Malam1, Anand J. Amin2, Ashish C. Zala, Vipul M. Navadiya, Dhruv Patel, Dharna A. Patel. STUDY OF OXIDATIVE STRESS PARAMETERS IN TYPE-II DIABETES MELLITUS AND THEIR CORRELATION WITH BLOOD GLUCOSE LEVEL International Journal of Current Research and Review. 8(13), July, 31-34
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