IJCRR - 2(11), November, 2010
Pages: 14-26
1,3,4-THIADIAZOLE AS ANTIINFLAMMATORY AGENT:A REVIEW
Author: Mehnaz Kamal, Ashok K Shakya, Talha Jawaid
Category: Healthcare
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Abstract:
1,3,4-Thiadiazole nucleus exhibited remarkable pharmacological activities. Literature indicates that compounds having 1,3,4-Thiadiazole nucleus have wide range of pharmacological activities that include antibacterial, antifungal, antitubercular, antiviral, antileishmanial, anti-inflammatory, analgesic, CNS depressant, anticonvulsant, anticancer, antioxidant, antidiabetic, molluscicidal, antihypertensive, diuretic. The present review provides a broad view of the anti-inflammatory activity possessed by compounds having a 1,3,4-Thiadiazole nucleus.
Keywords: Review; 1, 3, 4-Thiadiazole; Chemistry; anti-inflammatory Activity
Citation:
Mehnaz Kamal, Ashok K Shakya, Talha Jawaid. 1,3,4-THIADIAZOLE AS ANTIINFLAMMATORY AGENT:A REVIEW International Journal of Current Research and Review. 2(11), November, 14-26
References:
1. Horton DA, Bourne GT, Smyth ML. Chem. Rev. 2003; 103: 893.
2. (a) Thompson LA, Ellman JA. Chem. Rev. 1996; 96: 555; (b) Fruchtel JS, Jung G, Angew. Chem. Int. Ed. Engl. 1996; 35:17; (c) Nefzi A, Ostresh JM, Houghten RA. Chem. Rev. 1997; 97: 449; (d) Frazen RG. J. Comb. Chem. 2000; 2: 195.
3. Kumar H, Javed SA, Khan SA, Amir M. Synthesis and pharmacological evaluation of condensed heterocyclic 6- substituted-1,2,4-triazolo[3,4-b]-1,3,4- thiadiazole derivatives of naproxen. Eur. J. Med. Chem. 2008; xx: 1-11.
4. Amir M, Kumar H, Javed SA. Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted- 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives of naproxen. Bioorg. and Med. Chem. Lett. 2007; 17: 4504-4508.
5. Amir M, Kumar H, Javed SA. Condensed bridgehead nitrogen heterocyclic system: Synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4- yloxy acetic acid. Eur. J. Med. Chem. 2007; xx: 1-11.
6. Goksen US, Kelekci NG, Goktas O, Koysal Y, K?l?c E, Is?k S, Aktay G, Zalp MO. 1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5- methyl-2-benzoxazolinones: Synthesis, analgesic-anti-inflammatory and antimicrobial activities. Bioorg. Med. Chem. 2007; 15: 5738-5751.
7. Hafez HN, Hegab MI, Ahmed-Farag IS, El-Gazzar ABA. A facile regioselective synthesis of novel spiro-thioxanthene and spiro-xanthene-9',2-[1,3,4]thiadiazole derivatives as potential analgesic and anti-inflammatory agents. Bioorg. Med. Chem. Lett. 2008; 18: 4538-4543.
8. Kadi AA, El-Brollosy NR, Al-Deeb OA, Habib EE, Ibrahim TM, El-Emam AA. Synthesis, antimicrobial, and antiinflammatory activities of novel 2-(1- adamantyl)-5-substituted-1,3,4- oxadiazoles and 2-(1-adamantylamino)-5- substituted-1,3,4-thiadiazoles. Eur. J. Med. Chem. 2007; 42: 235-242.
9. Jadhav VB, Kulkarni MV, Rasal VP, Biradar SS, Vinay MD. Synthesis and anti-inflammatory evaluation of methylene bridged benzofuranyl imidazo[2,1-b][1,3,4]thiadiazoles. Eur. J. Med. Chem. 2008; 43: 1721-1729.
10. Hafez HN, Hegab MI, Ahmed-Farag IS, El-Gazzar AB. A facile regioselective synthesis of novel spiro-thioxanthene and spiro-xanthene-9',2- [1,3,4]thiadiazole derivatives as potential analgesic and antiinflammatory agents. Bioorg. Med. Chem. Lett. 2008; xxx: xxx-xxx.
11. Schenone S, Brullo C, Bruno O, Bondavalli F, Ranise A, Filippelli W, Rinaldi B, Capuano A, Falcone G. New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities. Bioorg. Med. Chem. 2006; 14: 1698-1705.
12. Amir M, Shikha K. Synthesis and antiinflammatory, analgesic, ulcerogenicand lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivatives. Eur. J. Med. Chemistry 2004; 39: 535-545.
13. Gadad AK, Palkar MB, Anand K, Noolvi MN, Boreddy TS, Wagwade J. Synthesis and biological evaluation of 2- trifluoromethyl/sulfonamido-5,6-diaryl substituted imidazo[2,1-b]-1,3,4- thiadiazoles: A novel class of cyclooxygenase-2 inhibitors. Bioorg. Med. Chem. 2008; 16: 276-283.
14. Palaska E, Sahin G, Kelicen P, Durlu NT, Altinok G. Synthesis and antiinflammatory activity of 1- acylthiosemicarbazides, 1,3,4- oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazole-3-thiones. Il Farmaco 2002; 57: 101-107.
15. Amir M, Kumar H, Javed SA. Bioorg. Med. Chem. Lett. 2007; 17: 4504-4508.
16. Bhati SK, Kumar A. Synthesis of new substituted azetidinoyl and thiazolidinoyl-1,3,4-thiadiazino (6,5-b) indoles as promising anti-inflammatory agents. Eur. J. Med. Chem. 2008; 43: 2323-2330.
17. Bekhit AA, Ashour HMA, Abdel Ghany YS, Bekhit AA, Baraka A. Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as antiinflammatory antimicrobial agents. Eur. J. Med. Chem. 2008; 43: 456-463.
18. Schenone S, Bruno O, Ranise A, Bondavalli F, Filippelli W, Falcone G, Giordano L, Vitelli MR. 3- Arylsulphonyl-5-arylamino-1,3,4- thiadiazol-2(3H)ones as Antiinflammatory and Analgesic Agents. Bioorg. and Med. Chemistry 2001; 9: 2149-2153.
19. Rostom SAF, El-Ashmawy IM, Razik HA, Badr MH, Ashour HMA. Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents. Bioorg. and Med. Chemistry 2009; 17: 882-895.
20. Kumar H, Javed SA, Khan SA, Amir M. 1,3,4-Oxadiazole/thiadiazole and 1,2,4- triazole derivatives of biphenyl-4-yloxy acetic acid: Synthesis and preliminary evaluation of biological properties. Eur. J. Med. Chemistry 2008; 43: 2688-2698.
21. Mathew V, Keshavayya J, Vaidya VP, Giles D. Studies on synthesis and pharmacological activities of 3,6- disubstituted-1,2,4-triazolo[3,4-b]-1,3,4- thiadiazoles and their dihydro analogues. Eur. J. Med. Chemistry 2007; 42: 823- 840.
22. Sharma R, Sainy J, Chaturvedi SC. 2- Amino-5-sulfanyl-1,3,4-thiadiazoles: A new series of selective cyclooxygenase- 2 inhibitors. Acta Pharm. 2008; 58: 317- 326.
23. Amir M, Kumar S. Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation properties of ibuprofen derivatives. Acta Pharm. 2007; 57: 31- 45.
24. Shakya AK, Patnaik GK, Mishra P. Synthesis and Biological evaluation of 2-[substituted acetyl]amino-5-alkyl- 1,3,4-thiadiazoles. Eur. J. Med. Chem. 1992; 27: 67-71.
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