IJCRR - Vol 08 Issue 14, July, 2016
HISTOPATHOLOGICAL STUDY OF SPINAL TUMOURS
Author: Jobanputra G. P., Parikh U. R., Goswami H. M.
Background: Spinal tumours are tumours that can occur within or adjacent to the spinal cord. Primary spinal cord tumours account for 2 to 4 percent of all primary central nervous system(CNS) tumours, one third of which are located in the intramedullary compartment.
Objective: To study the incidence of spinal tumour at Tertiary Care Teaching Hospital and to study the morphological and clinicoradiological correlation and relative incidence of various spinal tumours among different age groups and sex.
Methods: In the Present Study, all operated cases; exicsed bipsies and resected specimens are taken into consideration. After processing detail microscopic examination was carreied out.
Results: The peak age of incidence of spinal tumours was between 21-40 years of age, with the rmale:female ratio 1.57:1.Benign tumours (89%) are more common than malignant tumours (11%).Spinal tumours more commonly located in intradural (86%) than extradural(14%) locations. Malignant tumours mostly located on extradural locations(7%) than intradural locations(4%). Spinal tumours are more commonly located in thoracic region. Schwannoma(31%) is the most common spinal tumour followed by meningioma(24%), astrocytoma (11%), neurofibroma (8%) and ependymoma (8%). Hemangioma and lipoma are relatively less common.
Conclusion: The study can contribute to epidemiologic knowledge of Spinal cord tumours.
Keywords: Spinal Cord Tumours (SCT), Histopathology, Central Nervous System (CNS)
Jobanputra G. P., Parikh U. R., Goswami H. M.. HISTOPATHOLOGICAL STUDY OF SPINAL TUMOURS International Journal of Current Research and Review. Vol 08 Issue 14, July, 01-08
1. Chapter in book: Juan Rosai. Chapter-18. In : Rosai and Ackerman’s Surgical Pathology, Tenth Edition, Volume I, Testis; Mosby; Elsevier; 2004: 1412-1457.
2. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, et al. The WHO classification of tumours of the nervous system. J Neuropathol Exp Neurol 2002;61:215-25.
3. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. Classification of Tumours of the Nervous System, IARC Press, Lyon, France 2007.
4. Lucein J. Rubinstein: Tumours of the central nervous system, 2nd series, fascicle 6, 1972.
5. Minimum dataset for the histopathological reporting of tumours of CNS; 10th Sept. 2003
6. Shrivastava RK, Epstein FJ, Perin NI, et al. Intramedullary spinal cord tumours in patients older than 50 years of age: management and outcome analysis. J Neurosurg Spine 2005; 2:249.
7. Descriptive epidemiology of malignant and nonmalignant primary spinal cord, spinal meninges, and cauda equina tumours , United States, 2004-2007. Cancer 118:4220.
8. The WHO Classification of Tumours of Central Nervous Systerm; David N. Louis, Hiroko Ohgaki, Otmar D. Wiestler, Webster K. Cavenee; International Agency for Research on Cancer (IARC) 69008 Lyon, France, Heidelberg November 17-18, 2006.
9. Moein P, Behnamfar O, Khalighinejad N, Farajzadegan Z, Fard SA, Razavi M et al. A 12-year epidemiologic study on primary spinal cord tumours in Isfahan, Iran. J Res Med Sci 2013;18:17- 21.
10. Hirano k,et al.Eur spine J. 2012. Oct;21(10):2019-26. doi:10.1007/s00586-012-2345-5.Epub 2012 May 12.
11. Schellinger KA, Propp JM, Villano JL, McCarthy BJ. Descriptive epidemiology of primary spinal cord tumours . J Neurooncol 2008;87:173-9.