IJCRR - Vol 08 Issue 17, September, 2016
LEPTOSPIROSIS - AN ENIGMATIC ZOONOSIS
Author: Mythri B.A.
Leptospirosis is a zoonosis which has a global distribution. The disease is still an enigma 130 years post discovery. Leptospirosis is mainly a disease of the animals like the rodents and various other animals, wherein man is an accidental host. Leptospira is a spirochete, which to be visualised in a dark field microscope or in a light microscope after special staining techniques. It is a slow growing organism and requires special media like the Fletcher`s medium. Leptospirosis results when the person comes in contact with the organism either as an occupational hazard or during avocational exposure or during floods. The pathogenesis of leptospirosis is incompletely understood. Despite years of speculation, the route and mode of entry of leptospires in natural infections is not clear. The site of entry into host is through mucosal surfaces. Important portals of entry are fresh or partially healed abrasions of the skin and intact mucosa of the buccal cavity, nasal passages or conjunctiva. The disease can be seen in two forms, the mild anicteric form and the severe icteric form also known as Weil`s disease. The diagnosed leptospirosis cases are just the tip of the iceberg; many go undiagnosed due to the protean manifestations of the disease. The drug of choice for treatment is Penicillin. Vaccines are available for animals. An approved vaccine for humans is still awaited.
Keywords: Potentially fatal, Leptospirosis, Anicteric leptospirosis, Leptospira icterohaemorrhagiae
Mythri B.A.. LEPTOSPIROSIS - AN ENIGMATIC ZOONOSIS International Journal of Current Research and Review. Vol 08 Issue 17, September, 22-28
1. Gangadhar NL, Prabhudas K, Gajendragad MR, Shashibhushan J, Ahmed K. Leptospirosis: An enigma of zoonosis for the developing world. Infect Dis J.2006 Mar;15(1): 20-24.
2. Levett PN. Leptospirosis. Clin Microbiol Rev 2001 April; 14(2): 296-326.
3. Smits HL, Ananyina YV, Chereshky A, Dancel L, Lai-A-fat RFM, Chee HD et al. International multicenter evaluation of the clinical utility of a dipstick assay for detection of Leptospiraspecific Immunoglobulin M antibodies in human serum specimens. J Clin Microbiol 1999 Sept; 37(9): 2904-2909.
4. Pritchard DG, Spirochaetal and Leptospiral diseases. In: Parker MT, Collier LH, editors. Topley and Wilson`s Principles of bacteriology, virology and Immunity, 8th ed. London: Edward Arnold, 1990:605-640.
5. Ashford DA, Kaiser RM, Spiegel RA, Perkins BA, Weyant RS, Bragg SL et al, Asymptomatic infection and risk factors for Leptospirosis in Nicaragua. Am J Trop Med Hyg 2000; 63(5, 6): 249-254.
6. Mathew T, Satishchandra P, Mahadevan A, Nagarathna S, Yasha TC, Chandramukhi A, et al. Neuroleptospirosis- revisited: Expe-rience from a tertiary care neurological centre from south India. Indian J Med Res. 2006 August; 124: 155- 162.
7. Sonnenwirth AC. The Spirochetes. In: Sonnenwirth AC, Jarett L, editors. Gradwohl`s Clinical laboratory methods and diagnosis. 8th ed. St.Louis: Mosby, 1980: p 1853-1869.
8. Kumar RS, Leptospirosis: Recent Observations. In: Singal RK, editor. Medicine update vol.17.The association of physicians of India, proceedings of scientific sessions APICON 2007.New Delhi: Jaypee Brothers Medical Publishers; 2007:617-623.
9. Sanford JP. Leptospirosis. In: Schiff L, Schiff ER, editors. Diseases of the Liver.7th ed. Philadelphia: Lippincott Company, 1993: 1356-1361.
10. Faine S, Adler B, Bolin C, Perolat P. Leptospira and Leptospirosis.2nd ed. Melbourne, Australia: Medisci; 1999.
11. Christie AB. Leptospiral infections. Infectious diseases, epidemiology and clinical practice. 3rd ed. Edinburgh: Churchill Livingstone, 1980:848-867.
12. Feigin RD, Anderson DC. Bacterial infections, Leptospirosis. In: Feigin RD, Cherry JD, editors. Textbook of Paediatric Infectious Diseases, 2nd ed, Philadelphia: W.B. Saunders Company; 1987: p 1190-1205.
13. Sambasiva RR, Naveen G, Bhalla P, Agarwal SK. Leptospirosis in India and the rest of the world. Braz J Infect Dis 2003; 7(3):178-193.
14. Nizamuddin M, Tuteja U, Shukla J, Nair L, Sudarsana J. Early diagnosis of leptospirosis by antigen detection in blood. Indian J Med Microbiol 2006 Oct; 24(4): 342-345.
15. World Health Organization. Human leptospirosis: Guidance for diagnosis, surveillance and control [Book on the internet]. World Health Organization; 2003[cited 2015 May 15].Available from: http://www.who.int/csr/don/en/WHO_CDS_CSR_ EPH_2002.23.pdf?ua=1.
16. Johnson RC, Rogers P. 5-Fluorouracil as a selective agent for growth of leptospirae. J Bacteriol 1964 Feb; 879(2):422-426.
17. Ellis WA. The diagnosis of Leptospirosis in farm animals. In: Ellis WA, Little TWA, editors. The present state of leptospirosis diagnosis and control. Netherlands: Martinus Nijhoff Publishers; 1986: p13-31.
18. Speelman P. Leptospirosis. In: Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, editors. Harrison`s Principles of Internal Medicine. 16th ed, New York: McGraw Hill; 2005: p 988-990.
19. Sehgal S, Rana UVS, Bhatia R. Leptospirosis, current status and general aspects. Delhi: National Institute of Communicable Diseases (Directorate General of Health Services); 1991.
20. Levett PN. Leptospirosis. In: Mandell GL, Benett JE, Dolin R.editors. Principles and practice of infectious diseases.6th ed. Philadelphia: Churchill Livingstone; 2005: 2789-2795.
21. Granito A, Ballardini G, Fusconi M, Volta U, Muratori P, Sambri V, et al. A case of leptospirosis simulating colon cancer with liver metastases. World J Gastroenterol 2004 August 15; 10(16): 2455-2456.
22. Seenivasan NK, Prabhu N, Selvanayaki K, Raja SSS, Ratnam S. Human leptospirosis in Erode, South India: Serology, isolation and characterization of the isolates by Randomly Amplified Polymorphic DNA (RAPD) Fingerprinting. Jpn J Infect Dis 2004; 57:193-197.
23. Souza LA. Neuroleptospirosis: Unexplored and overlooked. Indian J Med Res. 2006 Aug; 124:125-128.
24. Sehgal SC. Epidemiological patterns of Leptospirosis. Indian J Med Microbiol 2006 Oct; 24(4): 310-311.
25. Laras K, Van CB, Bounlu K, Tien NTK, Olson JG, Thongchanh S, et al. The importance of leptospirosis in Southeast Asia. Am J Trop Med Hyg 2002; 67(3): 278-286.
26. Narita M, Fujitani S, Haake DA, Paterson DL. Leptospirosis after recreational exposure to water in the Yaeyama islands, Japan. Am J Trop Med Hyg. 2005; 73(4):652-656.
27. Waitkins SA. Review of the zoonotic aspects of Leptospirosis. In: Ellis WA, Little TWA, editors. The present state of leptospirosis diagnosis and control. Netherlands: Martinus Nijhoff Publishers; 1986: 235-241.
28. Little TWA. Changes in our understanding of the epidemiological techniques in the study of Leptospirosis. In: Ellis WA, Little TWA, editors. The present state of leptospirosis diagnosis and control. Netherlands: Martinus Nijhoff Publishers; 1986: 149- 173.
29. Mohanrao AMK. Preventive measures for leptospirosis: rodent control. Indian J Med Microbiol 2006 Oct; 24(6): 324-328.
30. Vinetz JM. Detection of leptospirosis in India. Arch Dis Child 2003; 88:1033.
31. Vinetz JM. A mountain out of a molehill: Do we treat acute leptospirosis, and If so, with what? Clin Infect Dis 2003; 36:1514- 1515.
32. Karande S,Bhatt M, Kelkar A, Kulkarni M, Varaiya A. An observational study to detect leptospirosis in Mumbai India, 2000. Arch Dis Child. 2003 Dec; 88(12): 1070-1075.
33. Souza LA, Sztajnbok J, Marques SR, Seguro AC. Leptospirosis- induced meningitis and acute renal failure in a 19 month old male child. J Med Microbiol 2006; 55: 795-797.
34. Suputtamongkol Y, Niwattayakul K, Suttinont C, Losuwanaluk K, Limpaiboon R, Chierakul W et al. An open randomized, controlled trial of Penicillin, Doxycycline, and Cefotaxime for patients with severe leptospirosis. Clin Infect Dis 2004; 39: 1417- 1424.
35. Srivastava SK. Prospects of developing Leptospiral vaccines for animals. Indian J Med Microbiol 2006 Oct; 24(4): 331-336.