IJCRR - 8(21), November, 2016
OBJECTIVE ASSESSMENT OF PHYSIOLOGIC AGEING CHANGES BY PATTERN REVERSAL VISUAL EVOKED POTENTIALS
Author: Sangeeta Gupta, Gaurav Gupta
Background: Impairment of visual information processing is one of the profound physiologic effects of ageing. Visual evoked potentials can record electrophysiological alterations in the visual pathways that can occur due to ageing and the nature of the impact in the older adults can be evaluated. Rapidly increasing size of the older population further emphasizes the acquisition of the data for this proportion of population optimizing the clinical evaluation in this group.
Methods: Pattern-reversal visual evoked potentials (PRVEP) were recorded in 120 healthy subjects in the age-group of 20-80 years (60 males and 60 females). Mean P100 latencies and N75-P100 amplitudes were compared in different age-groups by one way ANOVA. Correlations of latencies and amplitudes with age were performed using Pearson correlation coefficient. Gender differences were studied by unpaired t test. P value<0.05 was considered as statistically significant.
Results: Mean P100 latency increased with age (both eyes) (both the sexes) with statistical significance (p<0.01) while mean N75-P100 amplitude did not vary significantly (p>0.05). Males exhibited increased mean P100 latency as compared to females (p<0.0001) while increased mean N75-P100 amplitudes were recorded in females (P<0.0001).
Conclusion: Prolonged PRVEP P100 latency with age reflects electrophysiological alterations in visual pathways. Males demonstrate significant ageing changes earlier in life than females. Gender differences reveal increased P100 latency in males and increased N75-P100 amplitude in females in young as well as older adults. PRVEPs are useful objective measures to investigate the involvement of neural elements of visual system in the elderly individuals.
Keywords: Visual evoked potentials, Ageing, P100 latency, N 75-P100 amplitude
Sangeeta Gupta, Gaurav Gupta. OBJECTIVE ASSESSMENT OF PHYSIOLOGIC AGEING CHANGES BY PATTERN REVERSAL VISUAL EVOKED POTENTIALS International Journal of Current Research and Review. 8(21), November, 12-18
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