COMPARATIVE ANXIOLYTIC ACTIVITY OF VARIOUS DRUGS IN EXPERIMENTAL MODELS OF RATS

Kedare Rahul Vittha; B.B. Ghongane; R.J. Wagh

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IJCRR - 4(24), December, 2012

Pages: 77-85

COMPARATIVE ANXIOLYTIC ACTIVITY OF VARIOUS DRUGS IN EXPERIMENTAL MODELS OF RATS

Author: Kedare Rahul Vittha, B.B. Ghongane, R.J. Wagh

Category: Healthcare

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Abstract:

Objective: The aim of present work was to evaluate the anxiolytic efficacy of traditional anxiolytics along with antihistaminic, antipsychotic and analgesic in rats. Materials and Methods: The elevated plus maze model (EPMM) , open field test(OFT) and novelty induced hypophagia model(NIHM) were used to assess the effect on anxiety. The activity of Buspirone, Hydroxyzine, Haloperidol, Fluoxetine and Pethidine was compared with Diazepam, a standard anxiolytic drug. Results: Diazepam produced maximum anxiolysis in all anxiety models. The high dose Buspirone (5 mg/kg) was more effective compared than the low and medium dose (1.25mg/kg, 2.5mg/kg).) which showed significant increase in the time spent and number of entries in open arm in EPMM. The same doses of Buspirone showed significant increased in number of ambulations and number of rearing in OFT. The high dose (5 mg/kg) of Buspirone showed significantly decreased latency in NIHM. Overall, the activity of high dose of Buspirone was significantly less when compared with Diazepam but significantly more when compared to Hydroxyzine, Haloperidol, Fluoxetine and Pethidine. Conclusion: The result of the present study showed that Diazepam produced maximum anxiolysis in all anxiety models. Buspirone (high dose), Fluoxetine, Hydroxyzine, Haloperidol and Pethidine have more significant anxiolytic activity as compared to control group in elevated plus maze and novelty induced hypophagia test. In open field test Buspirone(high dose), Hydroxyzine Fluoxetine, Haloperidol and Pethidine have more significant anxiolytic activity as compared to control group.

Keywords: Anxiolytics, Diazepam, Buspirone , EPM model, OFT , Novelty induced hypophagia

Citation:

Kedare Rahul Vittha, B.B. Ghongane, R.J. Wagh. COMPARATIVE ANXIOLYTIC ACTIVITY OF VARIOUS DRUGS IN EXPERIMENTAL MODELS OF RATS International Journal of Current Research and Review. 4(24), December, 77-85

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