IJCRR - 5(6), March, 2013
EFFECT OF GENDER, AGE AND DURATION ON DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS
Author: Shabana S., Sasisekhar T.V.D.
Introduction: The burden of dyslipidemia is high in patients with diabetes. Although there is considerable evidence that abnormalities in serum lipids and lipid metabolism are important risk factors for increased incidence of coronary artery disease in type 2 diabetes, controversy exists regarding the association of dyslipidemia with the gender, age and duration of diabetes.
Objective: To study the prevalence and association of lipid disorders with gender, age, and duration of type 2 diabetes mellitus. Materials and methods: This is a cross-sectional prospective study of 270 diabetic patients at a tertiary care teaching hospital. The subjects were grouped based on the gender, age and duration of diabetes and into subgroups by a five year scale based on the age and duration of diabetes. Fasting venous blood samples were analyzed for serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein LDL-C and high-density lipoprotein cholesterol (HDL-C).
Results: Prevalence of dyslipidemia was more in female than in male diabetics. There was a gender preference of some lipid parameters. By age and by duration of diabetes, certain subgroups showed higher prevalence of dyslipidemia in both sexes. The degree of dyslipidemia by age showed an increasing trend and then reached a plateau, while it increased with increased duration of diabetes in both male and female diabetics. Although the distribution of lipid abnormalities increased with duration of diabetes, by age it showed no particular pattern of predominance in both sexes p>0.05.
Conclusion: The predominance of dyslipidemia at an older age, the increased prevalence and higher lipid abnormalities in the female diabetics indicate that female diabetics are at a higher risk of atherosclerosis and subsequently coronary artery disease compared to male diabetics.
Keywords: Dyslipidemia, type 2 diabetes mellitus, atherosclerosis, coronary artery disease
Shabana S., Sasisekhar T.V.D.. EFFECT OF GENDER, AGE AND DURATION ON DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS International Journal of Current Research and Review. 5(6), March, 104-113
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