IJCRR - 5(6), March, 2013
EVALUATION OF FERTILITY EFFICACY OF IONIDIUM SUFFRUTICOSUM EXTRACT ON SENILITY INDUCED STERILITY OF MALE ALBINO RATS
Author: B. Senthil Kumar, J. Vijaya Kumar, R. Selvaraj
Background: Ageing is associated with the diminished function of various tissues in the body. The gonadal function decreases with the increase in age. Testes undergo atrophy resulting in shrinkage of seminiferous tubules due to reduced testosterone hormone level in elderly male. The process of spermatogenesis decreases in old age when compared to young adults. Today’s lifestyle makes an adult sub fertile even in their earlier age of 30-40 years. To overcome this problem many non-hormonal preparations are in need, so an herbal trial was planned initially on animals which will be followed up to humans in future, if the herb proved to be safe. Objective: To evaluate the fertility efficacy of Ionidium suffruticosum extract on senility induced sterility of male albino rats.
Research Methodology: A total of 16 healthy senile male albino rats weighing 300 to 330 gm were selected. Ionidium suffruticosum extract of 200mg/kg bodyweight were administered orally to the senile experimental albino rats (n=8) and compared to the senile control albino rats (n=8) using various parameters and the drug’s efficacy was proved by the restitution of fertility in senile rats.
Results: The administration of the drug showed significant improvement of all the parameters in experimental rats when compared to control rats. The data’s were analyzed using student’s t test and found to be statistically significant.
Conclusion: The herb was found to be effective on the gonads of senile male albino rats, regaining its fertility to normal, when compared to control rats.
Keywords: Ionidium suffruticosum, senile rats, Sterility, Seminiferous tubule, Siddha Medicine
B. Senthil Kumar, J. Vijaya Kumar, R. Selvaraj. EVALUATION OF FERTILITY EFFICACY OF IONIDIUM SUFFRUTICOSUM EXTRACT ON SENILITY INDUCED STERILITY OF MALE ALBINO RATS International Journal of Current Research and Review. 5(6), March, 98-103
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